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There have been multiple recent proposals on using deep neural networks for code search using natural language. Common across these proposals is the idea of $\mathit{embedding}$ code and natural language queries, into real vectors and then…

Software Engineering · Computer Science 2019-10-16 Jose Cambronero , Hongyu Li , Seohyun Kim , Koushik Sen , Satish Chandra

Finding a template in a search image is an important task underlying many computer vision applications. Recent approaches perform template matching in a deep feature-space, produced by a convolutional neural network (CNN), which is found to…

Computer Vision and Pattern Recognition · Computer Science 2021-05-10 Bo Gao , M. W. Spratling

Tandem mass spectrometry has played a pivotal role in advancing proteomics, enabling the analysis of protein composition in biological samples. Despite the development of various deep learning methods for identifying amino acid sequences…

Quantitative Methods · Quantitative Biology 2024-03-18 Jun Xia , Shaorong Chen , Jingbo Zhou , Tianze Ling , Wenjie Du , Sizhe Liu , Stan Z. Li

We introduce a protein language model for determining the complete sequence of a peptide based on measurement of a limited set of amino acids. To date, protein sequencing relies on mass spectrometry, with some novel edman degregation based…

Proteins are sequences of amino acids that serve as the basic building blocks of living organisms. Despite rapidly growing databases documenting structural and functional information for various protein sequences, our understanding of…

Biomolecules · Quantitative Biology 2025-01-06 Weihang Dai

Statistical matching methods are widely used in the social and health sciences to estimate causal effects using observational data. Often the objective is to find comparable groups with similar covariate distributions in a dataset, with the…

Applications · Statistics 2021-01-19 Felix Bestehorn , Maike Bestehorn , Christian Kirches

Motivation: Protein embedding, which represents proteins as numerical vectors, is a crucial step in various learning-based protein annotation/classification problems, including gene ontology prediction, protein-protein interaction…

Genomics · Quantitative Biology 2024-05-21 Jiayu Shang , Cheng Peng , Yongxin Ji , Jiaojiao Guan , Dehan Cai , Xubo Tang , Yanni Sun

Embedding techniques have become essential components of large databases in the deep learning era. By encoding discrete entities, such as words, items, or graph nodes, into continuous vector spaces, embeddings facilitate more efficient…

Information Retrieval · Computer Science 2024-10-18 Shiwei Li , Zhuoqi Hu , Xing Tang , Haozhao Wang , Shijie Xu , Weihong Luo , Yuhua Li , Xiuqiang He , Ruixuan Li

Structure-based protein design has attracted increasing interest, with numerous methods being introduced in recent years. However, a universally accepted method for evaluation has not been established, since the wet-lab validation can be…

Quantitative Methods · Quantitative Biology 2023-12-04 Chuanrui Wang , Bozitao Zhong , Zuobai Zhang , Narendra Chaudhary , Sanchit Misra , Jian Tang

The selection of hyper-parameters is critical in Deep Learning. Because of the long training time of complex models and the availability of compute resources in the cloud, "one-shot" optimization schemes - where the sets of hyper-parameters…

Machine Learning · Computer Science 2017-06-13 Olivier Bousquet , Sylvain Gelly , Karol Kurach , Olivier Teytaud , Damien Vincent

Foundation models and their checkpoints have significantly advanced deep learning, boosting performance across various applications. However, fine-tuned models often struggle outside their specific domains and exhibit considerable…

Inferring the structural properties of a protein from its amino acid sequence is a challenging yet important problem in biology. Structures are not known for the vast majority of protein sequences, but structure is critical for…

Machine Learning · Computer Science 2019-10-17 Tristan Bepler , Bonnie Berger

The tandem mass spectrometry fragments a large number of molecules of the same peptide sequence into charged prefix and suffix subsequences, and then measures mass/charge ratios of these ions. The de novo peptide sequencing problem is to…

Computational Engineering, Finance, and Science · Computer Science 2007-05-23 Ting Chen , Ming-Yang Kao , Matthew Tepel , John Rush , George M. Church

Recently, automated medical image segmentation methods based on deep learning have achieved great success. However, they heavily rely on large annotated datasets, which are costly and time-consuming to acquire. Few-shot learning aims to…

Artificial Intelligence · Computer Science 2024-08-20 Jiayu Huo , Ruiqiang Xiao , Haotian Zheng , Yang Liu , Sebastien Ourselin , Rachel Sparks

Deep learning techniques have achieved specific results in recording device source identification. The recording device source features include spatial information and certain temporal information. However, most recording device source…

Sound · Computer Science 2022-12-06 Chunyan Zeng , Dongliang Zhu , Zhifeng Wang , Minghu Wu , Wei Xiong , Nan Zhao

Beam search and exhaustive search are two extreme ends of text decoding algorithms with respect to the search depth. Beam search is limited in both search width and depth, whereas exhaustive search is a global search that has no such…

Computation and Language · Computer Science 2023-08-29 Yuu Jinnai , Tetsuro Morimura , Ukyo Honda

Deep Learning (DL) algorithms hold great promise for applications in the field of computational biophysics. In fact, the vast amount of available molecular structures, as well as their notable complexity, constitutes an ideal context in…

Soft Condensed Matter · Physics 2019-01-07 Marco Giulini , Raffaello Potestio

This paper presents to the best of our knowledge the first end-to-end object tracking approach which directly maps from raw sensor input to object tracks in sensor space without requiring any feature engineering or system identification in…

Machine Learning · Computer Science 2016-03-10 Peter Ondruska , Ingmar Posner

Protein inverse folding aims to design an amino acid sequence that will fold into a given backbone structure, serving as a central task in protein design. Two main paradigms have been widely explored. Template-based methods exploit…

Machine Learning · Computer Science 2026-03-17 Yiran Zhu , Changxi Chi , Hongxin Xiang , Wenjie Du , Xiaoqi Wang , Jun Xia

We propose a novel approach to feature point matching, suitable for robust and accurate outdoor visual localization in long-term scenarios. Given a query image, we first match it against a database of registered reference images, using…

Computer Vision and Pattern Recognition · Computer Science 2019-08-22 Hugo Germain , Guillaume Bourmaud , Vincent Lepetit
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