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Working in a three-dimensional variant of Winfree's abstract Tile Assembly Model, we show that, for all $N \in \mathbb{N}$, there is a tile set that uniquely self-assembles into an $N \times N$ square shape at temperature 1 with optimal…

Computational Geometry · Computer Science 2014-11-06 David Furcy , Samuel Micka , Scott M. Summers

The integration of large language models (LLMs) with external tools has significantly expanded the capabilities of AI agents. However, as the diversity of both LLMs and tools increases, selecting the optimal model-tool combination becomes a…

Computation and Language · Computer Science 2026-01-08 Jinyang Wu , Guocheng Zhai , Ruihan Jin , Jiahao Yuan , Yuhao Shen , Shuai Zhang , Zhengqi Wen , Jianhua Tao

Genome assembly from the high-throughput sequencing (HTS) reads is a fundamental yet challenging computational problem. An intrinsic challenge is the uncertainty caused by the widespread repetitive elements. Here we get around the…

Genomics · Quantitative Biology 2016-09-13 Anqi Wang , Zheng Li , Zhanyu Wang , Lei M. Li

Deep neural networks (DNNs) have been deployed in myriad machine learning applications. However, advances in their accuracy are often achieved with increasingly complex and deep network architectures. These large, deep models are often…

Machine Learning · Computer Science 2020-04-22 Wenhan Xia , Hongxu Yin , Niraj K. Jha

In the field of algorithmic self-assembly, a long-standing unproven conjecture has been that of the NP-hardness of binary pattern tile set synthesis (2-PATS). The $k$-PATS problem is that of designing a tile assembly system with the…

Computational Complexity · Computer Science 2014-04-04 Lila Kari , Steffen Kopecki , Pierre-Étienne Meunier , Matthew J. Patitz , Shinnosuke Seki

The advancements in additive manufacturing (AM) technology have allowed for the production of geometrically complex parts with customizable designs. This versatility benefits large-scale space-frame structures, as the individual design of…

Computational Engineering, Finance, and Science · Computer Science 2023-12-05 Oguz Oztoprak , Alexander Paolini , Pierluigi D'Acunto , Ernst Rank , Stefan Kollmannsberger

Lattice structures have been widely used in various applications of additive manufacturing due to its superior physical properties. If modeled by triangular meshes, a lattice structure with huge number of struts would consume massive…

Computational Geometry · Computer Science 2021-02-02 Shengjun Liu , Tao Liu , Qiang Zou , Weiming Wang , Eugeni L. Doubrovski , Charlie C. L. Wang

DNA nanostructures with programmable shape and interactions can be used as building blocks for the self-assembly of crystalline materials with prescribed nanoscale features, holding a vast technological potential. Structural rigidity and…

Soft Condensed Matter · Physics 2019-01-30 Ryan A. Brady , William T. Kaufhold , Nicholas J. Brooks , Vito Foderà , Lorenzo Di Michele

The recently introduced Thermodynamic Binding Networks (TBN) model was developed with the purpose of studying self-assembling systems by focusing on their thermodynamically favorable final states, and ignoring the kinetic pathways through…

Emerging Technologies · Computer Science 2018-02-09 Cameron Chalk , Jacob Hendricks , Matthew J. Patitz , Michael Sharp

In this paper, a novel solution is introduced for visual Simultaneous Localization and Mapping (vSLAM) that is built up of Deep Learning components. The proposed architecture is a highly modular framework in which each component offers…

Computer Vision and Pattern Recognition · Computer Science 2022-07-18 Mátyás Szántó , György R. Bogár , László Vajta

DNA self-assembly is a robust and programmable approach for building structures at nanoscale. Researchers around the world have proposed and implemented different techniques to build two dimensional and three dimensional nano structures.…

Emerging Technologies · Computer Science 2014-05-19 Shikhar Kumar Gupta , Foram Joshi , Dixita Limbachiya , Manish K Gupta

We show how to design a universal shape replicator in a self-assembly system with both attractive and repulsive forces. More precisely, we show that there is a universal set of constant-size objects that, when added to any unknown hole-free…

Computational Geometry · Computer Science 2016-08-02 Cameron Chalk , Erik D. Demaine , Martin L. Demaine , Eric Martinez , Robert Schweller , Luis Vega , Tim Wylie

We report Monte Carlo simulations of a simple off-lattice patchy-particle model for DNA `bricks'. We relate the parameters that characterise this model with the binding free energy of pairs of single-stranded DNA molecules. We verify that…

Soft Condensed Matter · Physics 2016-07-21 Aleks Reinhardt , Daan Frenkel

In abstract models of algorithmic self-assembly, synchronization between attachments has emerged as a crucial distinction between the classical asynchronous model (aTAM) and a new synchronous model, the syncTAM. This paper presents recent…

Computational Geometry · Computer Science 2026-05-28 Florent Becker , Phillip Drake , Matthew J. Patitz , Ryder Smith

We present a modelling framework, and basic model parameterization, for the study of DNA origami folding at the level of DNA domains. Our approach is explicitly kinetic and does not assume a specific folding pathway. The binding of each…

We use Monte Carlo simulations and free-energy techniques to show that binary solutions of penta- and hexavalent two-dimensional patchy particles can form thermodynamically stable quasicrystals even at very narrow patch widths, provided…

Soft Condensed Matter · Physics 2016-11-11 Aleks Reinhardt , John S. Schreck , Flavio Romano , Jonathan P. K. Doye

The folding of RNA and DNA strands plays crucial roles in biological systems and bionanotechnology. However, studying these processes with high-resolution numerical models is beyond current computational capabilities due to the timescales…

Soft Condensed Matter · Physics 2024-02-07 F. Tosti Guerra , E. Poppleton , P. Šulc , L. Rovigatti

A challenge of molecular self-assembly is to understand how to design particles that self-assemble into a desired structure and not any of a potentially large number of undesired structures. Here we use simulation to show that a strategy of…

Statistical Mechanics · Physics 2017-02-27 Stephen Whitelam

We investigate a fundamental question regarding a benchmark class of shapes in one of the simplest, yet most widely utilized abstract models of algorithmic tile self-assembly. Specifically, we study the directed tile complexity of a $k…

Data Structures and Algorithms · Computer Science 2020-07-23 David Furcy , Scott M. Summers , Logan Withers

The earth texture with complex morphological geometry and compositions such as shale and carbonate rocks, is typically characterized with sparse field samples because of an expensive and time-consuming characterization process. Accordingly,…

Computer Vision and Pattern Recognition · Computer Science 2021-09-15 Sung Eun Kim , Hongkyu Yoon , Jonghyun Lee
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