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Understanding the relationship between cognition and intrinsic brain activity through purely data-driven approaches remains a significant challenge in neuroscience. Resting-state functional magnetic resonance imaging (rs-fMRI) offers a…

Machine Learning · Computer Science 2024-11-01 Yutong Gao , Vince D. Calhoun , Robyn L. Miller

Identifying objective neuroimaging biomarkers to forecast Alzheimer's disease (AD) progression is crucial for timely intervention. However, this task remains challenging due to the complex dysfunctions in the spatio-temporal characteristics…

Health risk prediction is one of the fundamental tasks under predictive modeling in the medical domain, which aims to forecast the potential health risks that patients may face in the future using their historical Electronic Health Records…

Machine Learning · Computer Science 2023-10-09 Yuan Zhong , Suhan Cui , Jiaqi Wang , Xiaochen Wang , Ziyi Yin , Yaqing Wang , Houping Xiao , Mengdi Huai , Ting Wang , Fenglong Ma

Latent diffusion models (LDMs) power state-of-the-art high-resolution generative image models. LDMs learn the data distribution in the latent space of an autoencoder (AE) and produce images by mapping the generated latents into RGB image…

Computer Vision and Pattern Recognition · Computer Science 2025-01-22 Tariq Berrada , Pietro Astolfi , Melissa Hall , Marton Havasi , Yohann Benchetrit , Adriana Romero-Soriano , Karteek Alahari , Michal Drozdzal , Jakob Verbeek

Deep neural networks have led to state-of-the-art results in many medical imaging tasks including Alzheimer's disease (AD) detection based on structural magnetic resonance imaging (MRI) data. However, the network decisions are often…

Quantitative Methods · Quantitative Biology 2019-08-28 Moritz Böhle , Fabian Eitel , Martin Weygandt , Kerstin Ritter

Deep neural networks have brought remarkable breakthroughs in medical image analysis. However, due to their data-hungry nature, the modest dataset sizes in medical imaging projects might be hindering their full potential. Generating…

Despite significant advances in deep learning, models often struggle to generalize well to new, unseen domains, especially when training data is limited. To address this challenge, we propose a novel approach for distribution-aware latent…

Computer Vision and Pattern Recognition · Computer Science 2023-08-29 Ran Liu , Sahil Khose , Jingyun Xiao , Lakshmi Sathidevi , Keerthan Ramnath , Zsolt Kira , Eva L. Dyer

Early diagnosis of Alzheimer's disease (AD) remains a major challenge due to the subtle and temporally irregular progression of structural brain changes in the prodromal stages. Existing deep learning approaches require large longitudinal…

Computer Vision and Pattern Recognition · Computer Science 2026-02-10 Maxx Richard Rahman , Mostafa Hammouda , Wolfgang Maass

Disease progression models infer group-level temporal trajectories of change in patients' features as a chronic degenerative condition plays out. They provide unique insight into disease biology and staging systems with individual-level…

Machine Learning · Computer Science 2025-06-25 Peter A. Wijeratne , Daniel C. Alexander

Alzheimer's disease (AD) is characterized by complex and largely unknown progression dynamics affecting the brain's morphology. Although the disease evolution spans decades, to date we cannot rely on long-term data to model the pathological…

Applications · Statistics 2019-08-14 Clement Abi Nader , Nicholas Ayache , Philippe Robert , Marco Lorenzi

Longitudinal imaging is able to capture both static anatomical structures and dynamic changes in disease progression toward earlier and better patient-specific pathology management. However, conventional approaches rarely take advantage of…

Preference optimization for diffusion models aims to align them with human preferences for images. Previous methods typically use Vision-Language Models (VLMs) as pixel-level reward models to approximate human preferences. However, when…

Computer Vision and Pattern Recognition · Computer Science 2025-10-03 Tao Zhang , Cheng Da , Kun Ding , Huan Yang , Kun Jin , Yan Li , Tingting Gao , Di Zhang , Shiming Xiang , Chunhong Pan

Alzheimer's disease is a progressive, neurodegenerative disorder that causes memory loss and cognitive decline. While there has been extensive research in applying deep learning models to Alzheimer's prediction tasks, these models remain…

Computer Vision and Pattern Recognition · Computer Science 2025-09-15 Emily Kaczmarek , Justin Szeto , Brennan Nichyporuk , Tal Arbel

Autoregressive (AR) models remain the standard for natural language generation but still suffer from high latency due to strictly sequential decoding. Recent diffusion-inspired approaches, such as LlaDA and Dream, mitigate this by…

Computation and Language · Computer Science 2025-10-16 Qinglin Zhu , Yizhen Yao , Runcong Zhao , Yanzheng Xiang , Amrutha Saseendran , Chen Jin , Philip Teare , Bin Liang , Yulan He , Lin Gui

Diffusion models have achieved significant progress in image generation. The pre-trained Stable Diffusion (SD) models are helpful for image deblurring by providing clear image priors. However, directly using a blurry image or pre-deblurred…

Computer Vision and Pattern Recognition · Computer Science 2025-02-07 Lingshun Kong , Jiawei Zhang , Dongqing Zou , Jimmy Ren , Xiaohe Wu , Jiangxin Dong , Jinshan Pan

Brain Magnetic Resonance Imaging (MRI) plays a central role in studying neurological development, aging, and diseases. One key application is Brain Age Prediction (BAP), which estimates an individual's biological brain age from MRI data.…

Computer Vision and Pattern Recognition · Computer Science 2026-01-09 Danilo Danese , Angela Lombardi , Matteo Attimonelli , Giuseppe Fasano , Tommaso Di Noia

This study presents a neural network-enhanced approach to modeling disease spread dynamics over time and space. Neural networks are used to estimate time-varying parameters, with two calibration methods explored: Approximate Bayesian…

Quantitative Methods · Quantitative Biology 2024-10-29 Randy L. Caga-anan

Alzheimer's disease (AD) is known as one of the major causes of dementia and is characterized by slow progression over several years, with no treatments or available medicines. In this regard, there have been efforts to identify the risk of…

Computer Vision and Pattern Recognition · Computer Science 2020-08-28 Wonsik Jung , Eunji Jun , Heung-Il Suk

Deep generative models have emerged as promising tools for detecting arbitrary anomalies in data, dispensing with the necessity for manual labelling. Recently, autoregressive transformers have achieved state-of-the-art performance for…

Magnetic Resonance Imaging (MRI) reconstruction is essential in medical diagnostics. As the latest generative models, diffusion models (DMs) have struggled to produce high-fidelity images due to their stochastic nature in image domains.…

Image and Video Processing · Electrical Eng. & Systems 2025-07-01 Lingtong Zhang , Mengdie Song , Xiaohan Hao , Huayu Mai , Bensheng Qiu