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If the same data is used for both clustering and for testing a null hypothesis that is formulated in terms of the estimated clusters, then the traditional hypothesis testing framework often fails to control the Type I error. Gao et al.…

Methodology · Statistics 2024-05-28 Youngjoo Yun , Yinqiu He

Clustering techniques applied to multivariate data are a very useful tool in Statistics and have been fully studied in the literature. Nevertheless, these clustering methodologies are less well known when dealing with functional data. Our…

Methodology · Statistics 2023-12-01 Belén Pulido , Alba María Franco-Pereira , Rosa Elvira Lillo

We aim to incorporate variable selection routines into variable-by-variable (or sequential) imputation in clustered data to achieve computational improvement in applications with large-scale health data. Specifically, we utilize variable…

Methodology · Statistics 2025-04-08 Qiushuang Li , Recai Yucel

This study proposes a Transformer-based longitudinal modeling method to address challenges in clinical risk classification with heterogeneous Electronic Health Record (EHR) data, including irregular temporal patterns, large modality…

Machine Learning · Computer Science 2025-11-07 Anzhuo Xie , Wei-Chen Chang

Evaluating the clinical similarities between pairwise patients is a fundamental problem in healthcare informatics. A proper patient similarity measure enables various downstream applications, such as cohort study and treatment comparative…

Machine Learning · Statistics 2019-02-12 Zihao Zhu , Changchang Yin , Buyue Qian , Yu Cheng , Jishang Wei , Fei Wang

Electronic Health Records (EHR) have revolutionized healthcare by digitizing patient data, improving accessibility, and streamlining clinical workflows. However, extracting meaningful insights from these complex and multimodal datasets…

Artificial Intelligence · Computer Science 2025-10-27 Naama Kashani , Mira Cohen , Uri Shaham

We develop and evaluate a data-driven approach for detecting unusual (anomalous) patient-management actions using past patient cases stored in an electronic health record (EHR) system. Our hypothesis is that patient-management actions that…

Machine Learning · Computer Science 2026-05-07 Milos Hauskrecht , Michal Valko , Shyam Visweswaran , Iyad Batal , Gilles Clermont , Gregory Cooper

This study introduces a predictive maintenance strategy for high pressure industrial compressors using sensor data and features derived from unsupervised clustering integrated into classification models. The goal is to enhance model…

Machine Learning · Computer Science 2024-11-22 Alessandro Costa , Emilio Mastriani , Federico Incardona , Kevin Munari , Sebastiano Spinello

Predicting the health risks of patients using Electronic Health Records (EHR) has attracted considerable attention in recent years, especially with the development of deep learning techniques. Health risk refers to the probability of the…

Machine Learning · Computer Science 2022-11-15 Yuxi Liu , Shaowen Qin , Antonio Jimeno Yepes , Wei Shao , Zhenhao Zhang , Flora D. Salim

In epidemiological cohort studies, the relative risk (also known as risk ratio) is a major measure of association to summarize the results of two treatments or exposures. Generally, it measures the relative change in disease risk as a…

Methodology · Statistics 2022-07-05 Gopal Nath , Krishna K. Saha , Suojin Wang

In an age of increasingly large data sets, investigators in many different disciplines have turned to clustering as a tool for data analysis and exploration. Existing clustering methods, however, typically depend on several nontrivial…

Quantitative Methods · Quantitative Biology 2009-11-11 Noam Slonim , Gurinder Singh Atwal , Gasper Tkacik , William Bialek

Clustering is a widely-used data mining tool, which aims to discover partitions of similar items in data. We introduce a new clustering paradigm, \emph{accordant clustering}, which enables the discovery of (predefined) group level insights.…

Machine Learning · Computer Science 2017-04-11 Amit Dhurandhar , Margareta Ackerman , Xiang Wang

Irregularly sampled time series data are common in a variety of fields. Many typical methods for drawing insight from data fail in this case. Here we attempt to generalize methods for clustering trajectories to irregularly and sparsely…

Quantitative Methods · Quantitative Biology 2021-09-01 Gary K. Nave , Swati Padhee , Amanuel Alambo , Tanvi Banerjee , Nirmish Shah , Daniel M. Abrams

Post-selection inference is a statistical technique for determining salient variables after model or variable selection. Recently, selective inference, a kind of post-selection inference framework, has garnered the attention in the…

Methodology · Statistics 2019-06-28 Yuta Umezu , Ichiro Takeuchi

The continuously increasing cost of the US healthcare system has received significant attention. Central to the ideas aimed at curbing this trend is the use of technology, in the form of the mandate to implement electronic health records…

Information Retrieval · Computer Science 2017-03-24 Pranjul Yadav , Michael Steinbach , Vipin Kumar , Gyorgy Simon

In heterogeneous disorders like Parkinson's disease (PD), differentiating the affected population into subgroups plays a key role in future research. Discovering subgroups can lead to improved treatments through more powerful enrichment of…

Methodology · Statistics 2023-08-08 Elliot Burghardt , Daniel Sewell , Joseph Cavanaugh

We develop a novel algorithm, Predictive Hierarchical Clustering (PHC), for agglomerative hierarchical clustering of current procedural terminology (CPT) codes. Our predictive hierarchical clustering aims to cluster subgroups, not…

Methodology · Statistics 2017-08-03 Elizabeth C. Lorenzi , Stephanie L. Brown , Zhifei Sun , Katherine Heller

Electronic health records (EHRs) include simple features like patient age together with more complex data like care history that are informative but not easily represented as individual features. To better harness such data, we developed an…

Artificial Intelligence · Computer Science 2023-02-14 Jacqueline K. Kueper , Jennifer Rayner , Daniel J. Lizotte

In longitudinal data analysis, observation points of repeated measurements over time often vary among subjects except in well-designed experimental studies. Additionally, measurements for each subject are typically obtained at only a few…

Methodology · Statistics 2024-11-14 Michio Yamamoto , Yoshikazu Terada

The wide adoption of Electronic Health Records (EHR) has resulted in large amounts of clinical data becoming available, which promises to support service delivery and advance clinical and informatics research. Deep learning techniques have…

Machine Learning · Computer Science 2022-02-14 Thanh Nguyen-Duc , Natasha Mulligan , Gurdeep S. Mannu , Joao H. Bettencourt-Silva
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