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The growing availability of well-organized Electronic Health Records (EHR) data has enabled the development of various machine learning models towards disease risk prediction. However, existing risk prediction methods overlook the…

Machine Learning · Computer Science 2024-06-17 Ziyang Zhang , Hejie Cui , Ran Xu , Yuzhang Xie , Joyce C. Ho , Carl Yang

For many applications, it is critical to interpret and validate groups of observations obtained via clustering. A common validation approach involves testing differences in feature means between observations in two estimated clusters. In…

Methodology · Statistics 2023-11-29 Yiqun T. Chen , Lucy L. Gao

Electronic Health Record (EHR) data has been of tremendous utility in Artificial Intelligence (AI) for healthcare such as predicting future clinical events. These tasks, however, often come with many challenges when using classical machine…

Machine Learning · Computer Science 2021-04-08 Tingyi Wanyan , Jing Zhang , Ying Ding , Ariful Azad , Zhangyang Wang , Benjamin S Glicksberg

Accurate predictions, as with machine learning, may not suffice to provide optimal healthcare for every patient. Indeed, prediction can be driven by shortcuts in the data, such as racial biases. Causal thinking is needed for data-driven…

In data containing heterogeneous subpopulations, classification performance benefits from incorporating the knowledge of cluster structure in the classifier. Previous methods for such combined clustering and classification either 1) are…

Machine Learning · Computer Science 2023-01-04 Shivin Srivastava , Siddharth Bhatia , Lingxiao Huang , Lim Jun Heng , Kenji Kawaguchi , Vaibhav Rajan

In the dynamic hospital setting, decision support can be a valuable tool for improving patient outcomes. Data-driven inference of future outcomes is challenging in this dynamic setting, where long sequences such as laboratory tests and…

Quantitative Methods · Quantitative Biology 2024-04-25 Alan D. Kaplan , Priyadip Ray , John D. Greene , Vincent X. Liu

Learning from electronic medical records (EMR) is challenging due to their relational nature and the uncertain dependence between a patient's past and future health status. Statistical relational learning is a natural fit for analyzing EMRs…

Machine Learning · Computer Science 2012-07-03 Jesse Davis , Vitor Santos Costa , Peggy Peissig , Michael Caldwell , Elizabeth Berg , David Page

Clustered standard errors and approximate randomization tests are popular inference methods that allow for dependence within observations. However, they require researchers to know the cluster structure ex ante. We propose a procedure to…

Econometrics · Economics 2022-01-14 Yong Cai

Electronic health record (EHR) data are becoming an increasingly common data source for understanding clinical risk of acute events. While their longitudinal nature presents opportunities to observe changing risk over time, these analyses…

Determining phenotypes of diseases can have considerable benefits for in-hospital patient care and to drug development. The structure of high dimensional data sets such as electronic health records are often represented through an embedding…

The association between multidimensional exposure patterns and outcomes is commonly investigated by first applying cluster analysis algorithms to derive patterns and then estimating the associations. However, errors in the underlying…

Methodology · Statistics 2023-05-31 Timm Intemann , Iris Pigeot

We propose a Bayesian approach for model-based clustering of multivariate categorical data where variables are allowed to be associated within clusters and the number of clusters is unknown. The approach uses a two-layer mixture of finite…

Methodology · Statistics 2024-07-09 Gertraud Malsiner-Walli , Bettina Grün , Sylvia Frühwirth-Schnatter

In this paper, we analyze electroencephalograms (EEG) which are recordings of brain electrical activity. We develop new clustering methods for identifying synchronized brain regions, where the EEGs show similar oscillations or waveforms…

Methodology · Statistics 2020-07-29 Tianbo Chen , Ying Sun , Carolina Euan , Hernando Ombao

Fetal heart rate (FHR) monitoring, before and during labor, is a very important medical practice in the detection of fetuses in danger. We clustered FHR tracings by compression in order to identify abnormal ones. We use a recently…

Tissues and Organs · Quantitative Biology 2007-05-23 C. Costa Santos , J. Bernardes , P. Vitanyi , L. Antunes

As data sets continue to grow in size and complexity, effective and efficient techniques are needed to target important features in the variable space. Many of the variable selection techniques that are commonly used alongside clustering…

Computation · Statistics 2013-03-22 Jeffrey L. Andrews , Paul D. McNicholas

We introduce a new clustering method for the classification of functional data sets by their probabilistic law, that is, a procedure that aims to assign data sets to the same cluster if and only if the data were generated with the same…

Methodology · Statistics 2023-12-29 Antonio Galves , Fernando Najman , Marcela Svarc , Claudia D. Vargas

Many diagnostic errors occur because clinicians cannot easily access relevant information in patient Electronic Health Records (EHRs). In this work we propose a method to use LLMs to identify pieces of evidence in patient EHR data that…

Traditional statistical inference in cluster randomized trials typically invokes the asymptotic theory that requires the number of clusters to approach infinity. In this article, we propose an alternative conformal causal inference…

Methodology · Statistics 2024-10-03 Bingkai Wang , Fan Li , Mengxin Yu

Objectives: Electronic health records (EHRs) are only a first step in capturing and utilizing health-related data - the challenge is turning that data into useful information. Furthermore, EHRs are increasingly likely to include data…

Artificial Intelligence · Computer Science 2012-08-20 Casey Bennett , Tom Doub , Rebecca Selove

Background: When planning a cluster randomized trial, evaluators often have access to an enumerated cohort representing the target population of clusters. Practicalities of conducting the trial, such as the need to oversample clusters with…

Methodology · Statistics 2024-09-19 Sarah E. Robertson , Jon A. Steingrimsson , Issa J. Dahabreh