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Sepsis is a severe condition responsible for many deaths in the United States and worldwide, making accurate prediction of outcomes crucial for timely and effective treatment. Previous studies employing machine learning faced limitations in…

Machine Learning · Computer Science 2025-01-03 Arseniy Shumilov , Yueting Zhu , Negin Ashrafi , Armin Abdollahi , Greg Placencia , Kamiar Alaei , Maryam Pishgar

Objective: To compare different deep learning architectures for predicting the risk of readmission within 30 days of discharge from the intensive care unit (ICU). The interpretability of attention-based models is leveraged to describe…

Machine Learning · Computer Science 2020-01-08 Sebastiano Barbieri , James Kemp , Oscar Perez-Concha , Sradha Kotwal , Martin Gallagher , Angus Ritchie , Louisa Jorm

Clinical decisions are high-stakes and require explicit justification, making model interpretability essential for auditing deep clinical models prior to deployment. As the ecosystem of model architectures and explainability methods…

Machine Learning · Computer Science 2026-03-27 Yongda Fan , John Wu , Andrea Fitzpatrick , Naveen Baskaran , Jimeng Sun , Adam Cross

Background: Sepsis-Associated Acute Kidney Injury (SA-AKI) leads to high mortality in intensive care. This study develops machine learning models using the Medical Information Mart for Intensive Care IV (MIMIC-IV) database to predict…

Machine Learning · Computer Science 2025-05-20 Shuheng Chen , Junyi Fan , Elham Pishgar , Kamiar Alaei , Greg Placencia , Maryam Pishgar

Sepsis is a potentially life threatening inflammatory response to infection or severe tissue damage. It has a highly variable clinical course, requiring constant monitoring of the patient's state to guide the management of intravenous…

Machine Learning · Computer Science 2022-02-21 Thesath Nanayakkara , Gilles Clermont , Christopher James Langmead , David Swigon

Sepsis is a leading cause of mortality in intensive care units (ICUs) and costs hospitals billions annually. Treating a septic patient is highly challenging, because individual patients respond very differently to medical interventions and…

Machine Learning · Computer Science 2017-05-24 Aniruddh Raghu , Matthieu Komorowski , Leo Anthony Celi , Peter Szolovits , Marzyeh Ghassemi

Sepsis is a condition caused by the body's overwhelming and life-threatening response to infection, which can lead to tissue damage, organ failure, and finally death. Common signs and symptoms include fever, increased heart rate, increased…

Machine Learning · Computer Science 2017-09-07 Eitam Sheetrit , Nir Nissim , Denis Klimov , Lior Fuchs , Yuval Elovici , Yuval Shahar

Accurate and interpretable mortality risk prediction in intensive care units (ICUs) remains a critical challenge due to the irregular temporal structure of electronic health records (EHRs), the complexity of longitudinal disease…

Machine Learning · Computer Science 2026-03-10 Zahra Jafari , Azadeh Zamanifar , Amirfarhad Farhadi

Current machine learning models aiming to predict sepsis from Electronic Health Records (EHR) do not account for the heterogeneity of the condition, despite its emerging importance in prognosis and treatment. This work demonstrates the…

Quantitative Methods · Quantitative Biology 2020-11-24 Zina Ibrahim , Honghan Wu , Ahmed Hamoud , Lukas Stappen , Richard Dobson , Andrea Agarossi

Complex deep learning models show high prediction tasks in various clinical prediction tasks but their inherent complexity makes it more challenging to explain model predictions for clinicians and healthcare providers. Existing research on…

Machine Learning · Computer Science 2026-02-06 Sayantan Kumar , Sean C. Yu , Thomas Kannampallil , Zachary Abrams , Andrew Michelson , Philip R. O. Payne

Earthquake early warning systems play crucial roles in reducing the risk of seismic disasters. Previously, the dominant modeling system was the single-station models. Such models digest signal data received at a given station and predict…

Machine Learning · Computer Science 2024-12-25 Yu-Ming Huang , Kuan-Yu Chen , Wen-Wei Lin , Da-Yi Chen

Objective: Epilepsy is one of the most prevalent neurological diseases among humans and can lead to severe brain injuries, strokes, and brain tumors. Early detection of seizures can help to mitigate injuries, and can be used to aid the…

Computer Vision and Pattern Recognition · Computer Science 2020-11-20 Theekshana Dissanayake , Tharindu Fernando , Simon Denman , Sridha Sridharan , Clinton Fookes

Mortality risk is a major concern to patients have just been discharged from the intensive care unit (ICU). Many studies have been directed to construct machine learning models to predict such risk. Although these models are highly…

Applications · Statistics 2021-01-20 Eugene T. Y. Ang , Milashini Nambiar , Yong Sheng Soh , Vincent Y. F. Tan

Intensive Care in-hospital mortality prediction has various clinical applications. Neural prediction models, especially when capitalising on clinical notes, have been put forward as improvement on currently existing models. However, to be…

Computation and Language · Computer Science 2022-12-14 Miguel Rios , Ameen Abu-Hanna

We developed an explainable artificial intelligence (AI) early warning score (xAI-EWS) system for early detection of acute critical illness. While maintaining a high predictive performance, our system explains to the clinician on which…

Vital signs, such as heart rate and blood pressure, are critical indicators of patient health and are widely used in clinical monitoring and decision-making. While deep learning models have shown promise in forecasting these signals, their…

Machine Learning · Computer Science 2025-09-18 Li Rong Wang , Thomas C. Henderson , Yew Soon Ong , Yih Yng Ng , Xiuyi Fan

Early prediction of cerebral palsy is essential as it leads to early treatment and monitoring. Deep learning has shown promising results in biomedical engineering thanks to its capacity of modelling complicated data with its non-linear…

Computer Vision and Pattern Recognition · Computer Science 2021-06-09 Manli Zhu , Qianhui Men , Edmond S. L. Ho , Howard Leung , Hubert P. H. Shum

Sepsis is a life-threatening disease with high morbidity, mortality and healthcare costs. The early prediction and administration of antibiotics and intravenous fluids is considered crucial for the treatment of sepsis and can save…

Computation and Language · Computer Science 2021-07-26 Fred Qin , Vivek Madan , Ujjwal Ratan , Zohar Karnin , Vishaal Kapoor , Parminder Bhatia , Taha Kass-Hout

Although timely sepsis diagnosis and prompt interventions in Intensive Care Unit (ICU) patients are associated with reduced mortality, early clinical recognition is frequently impeded by non-specific signs of infection and failure to detect…

Machine Learning · Computer Science 2018-06-28 Tony Wang , Tom Velez , Emilia Apostolova , Tim Tschampel , Thuy L. Ngo , Joy Hardison

Attention mechanism is effective in both focusing the deep learning models on relevant features and interpreting them. However, attentions may be unreliable since the networks that generate them are often trained in a weakly-supervised…

Machine Learning · Statistics 2020-06-11 Jay Heo , Hae Beom Lee , Saehoon Kim , Juho Lee , Kwang Joon Kim , Eunho Yang , Sung Ju Hwang