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Combining dependent p-values poses a long-standing challenge in statistical inference, particularly when aggregating findings from multiple methods to enhance signal detection. Recently, p-value combination tests based on regularly…

Methodology · Statistics 2025-04-22 Lin Gui , Yuchao Jiang , Jingshu Wang

The problem of combining p-values is an old and fundamental one, and the classic assumption of independence is often violated or unverifiable in many applications. There are many well-known rules that can combine a set of arbitrarily…

Statistics Theory · Mathematics 2025-03-21 Matteo Gasparin , Ruodu Wang , Aaditya Ramdas

It is often of interest to test a global null hypothesis using multiple, possibly dependent $p$-values by combining their strengths while controlling the type-I error. Recently, several heavy-tailed combination tests, such as the harmonic…

Statistics Theory · Mathematics 2026-03-25 Parijat Chakraborty , F. Richard Guo , Kerby Shedden , Stilian Stoev

Many multiple testing procedures make use of the p-values from the individual pairs of hypothesis tests, and are valid if the p-value statistics are independent and uniformly distributed under the null hypotheses. However, it has recently…

Methodology · Statistics 2011-08-25 Joshua D. Habiger , Edsel A. Pena

This paper proposes general methods for the problem of multiple testing of a single hypothesis, with a standard goal of combining a number of p-values without making any assumptions about their dependence structure. An old result by…

Statistics Theory · Mathematics 2019-10-09 Vladimir Vovk , Ruodu Wang

We study the harmonic mean of non-zero complex-valued random variables (complex harmonic mean) and establish several geometric estimates and bounds. In contrast to the classical positive-valued case, complex harmonic means may lie outside…

Complex Variables · Mathematics 2026-02-10 Atsushi Nakayasu

Methods of merging several p-values into a single p-value are important in their own right and widely used in multiple hypothesis testing. This paper is the first to systematically study the admissibility (in Wald's sense) of p-merging…

Statistics Theory · Mathematics 2021-03-30 Vladimir Vovk , Bin Wang , Ruodu Wang

Increased availability of data and accessibility of computational tools in recent years have created unprecedented opportunities for scientific research driven by statistical analysis. Inherent limitations of statistics impose constrains on…

Genomics · Quantitative Biology 2016-09-13 Olga A. Vsevolozhskaya , Gabriel Ruiz , Dmitri V. Zaykin

We generalize the well-known mean value inequality of subharmonic functions for a slightly more general function class. We also apply this generalized mean value inequality to weighted boundary behavior and nonintegrability questions of…

Classical Analysis and ODEs · Mathematics 2007-05-23 Juhani Riihentaus

Evaluating the joint significance of covariates is of fundamental importance in a wide range of applications. To this end, p-values are frequently employed and produced by algorithms that are powered by classical large-sample asymptotic…

Methodology · Statistics 2017-05-11 Yingying Fan , Emre Demirkaya , Jinchi Lv

In meta analysis, multiple hypothesis testing and many other methods, p-values are utilized as inputs and assumed to be uniformly distributed over the unit interval under the null hypotheses. If data used to generate p-values have discrete…

Methodology · Statistics 2026-02-24 Joshua Habiger , Pratyaydipta Rudra

This article addresses issues of model criticism and model comparison in Bayesian contexts, and focusses on the use of the so-called posterior predictive p-values (ppp values). These involve a general discrepancy or conflict measure and…

Methodology · Statistics 2026-05-26 Nils Lid Hjort , Fredrik A. Dahl , Gunnhildur Högnadóttir Steinbakk

Heavy-tailed combination tests, such as the Cauchy combination test and harmonic mean p-value method, are widely used for testing global null hypotheses by aggregating dependent p-values. However, their theoretical guarantees under general…

Statistics Theory · Mathematics 2025-08-11 Lin Gui , Tiantian Mao , Jingshu Wang , Ruodu Wang

We study a large-scale one-sided multiple testing problem in which test statistics follow normal distributions with unit variance, and the goal is to identify signals with positive mean effects. A conventional approach is to compute…

Methodology · Statistics 2026-05-15 Kwangok Seo , Johan Lim , Hyungwon Choi , Jaesik Jeong

Various methods of combining individual p-values into one p-value are widely used in many areas of statistical applications. We say that a combining method is valid for arbitrary dependence (VAD) if it does not require any assumption on the…

Statistics Theory · Mathematics 2021-08-17 Yuyu Chen , Peng Liu , Ken Seng Tan , Ruodu Wang

A 2p-times continuously differentiable complex valued function $f = u + iv$ in a simply connected domain is polyharmonic (or p-harmonic) if it satisfies the polyharmonic equation $\Delta^pF = 0$ . Every polyharmonic mapping f can be written…

Complex Variables · Mathematics 2016-10-05 Layan El Hajj

We begin by shortly recalling a generalized mean value inequality for subharmonic functions, and two applications of it: first a weighted boundary behavior result (with some new references and remarks), and then a borderline case result to…

Analysis of PDEs · Mathematics 2007-05-23 Juhani Riihentaus

Besides the classical distinction of correlation and dependence, many dependence measures bear further pitfalls in their application and interpretation. The aim of this paper is to raise and recall awareness of some of these limitations by…

Methodology · Statistics 2020-04-17 Björn Böttcher

Generalizing the well-known mean-value property of harmonic functions, we prove that a p-harmonic function of two variables satisfies, in a viscosity sense, two asymptotic formulas involving its local statistics. Moreover, we show that…

Analysis of PDEs · Mathematics 2011-08-10 David Hartenstine , Matthew Rudd

Results involving various mean value properties are reviewed for harmonic, biharmonic and metaharmonic functions. It is also considered how the standard mean value property can be weakened to imply harmonicity and belonging to other classes…

Analysis of PDEs · Mathematics 2019-05-23 Nikolay Kuznetsov
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