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The paper introduces a framework for the evaluation of the encoding of factual scientific knowledge, designed to streamline the manual evaluation process typically conducted by domain experts. Inferring over and extracting information from…

Computation and Language · Computer Science 2024-10-21 Magdalena Wysocka , Oskar Wysocki , Maxime Delmas , Vincent Mutel , Andre Freitas

Large Language Models (LLMs) have demonstrated remarkable efficiency in tackling various tasks based on human instructions, but studies reveal that they often struggle with tasks requiring reasoning, such as math or physics. This limitation…

Computation and Language · Computer Science 2024-10-08 Ruoyu Wang , Xiaoxuan Li , Lina Yao

In recent years, Large Language Models (LLMs) have achieved significant success in natural language processing (NLP) and various interdisciplinary areas. However, applying LLMs to chemistry is a complex task that requires specialized domain…

Machine Learning · Computer Science 2024-02-05 Chang Liao , Yemin Yu , Yu Mei , Ying Wei

Although LLM-based agents are proven to master tool orchestration in scientific fields, particularly chemistry, their single-task performance remains limited by underlying tool constraints. To this end, we propose tool amplification, a…

Machine Learning · Computer Science 2026-04-20 Zhucong Li , Powei Chang , Jin Xiao , Zhijian Zhou , Qianyu He , Jiaqing Liang , Fenglei Cao , Xu Yinghui , Yuan Qi

Reducing hallucination of Large Language Models (LLMs) is imperative for use in the sciences, where reliability and reproducibility are crucial. However, LLMs inherently lack long-term memory, making it a nontrivial, ad hoc, and inevitably…

Computation and Language · Computer Science 2024-10-11 Yuan Chiang , Elvis Hsieh , Chia-Hong Chou , Janosh Riebesell

Large language models (LLMs) are increasingly applied to materials science questions, including literature comprehension, property prediction, materials discovery and alloy design. At the same time, a wide range of physics-based…

Materials Science · Physics 2025-12-17 Siyu Liu , Bo Hu , Beilin Ye , Jiamin Xu , David J. Srolovitz , Tongqi Wen

This study explores the application of large language models (LLMs) with callable tools in energy and power engineering domain, focusing on gas path analysis of gas turbines. We developed a dual-agent tool-calling process to integrate…

Artificial Intelligence · Computer Science 2024-06-13 Tao Song , Yuwei Fan , Chenlong Feng , Keyu Song , Chao Liu , Dongxiang Jiang

Discovering new materials can have significant scientific and technological implications but remains a challenging problem today due to the enormity of the chemical space. Recent advances in machine learning have enabled data-driven methods…

Materials Science · Physics 2024-06-21 Shuyi Jia , Chao Zhang , Victor Fung

In practice, clinicians achieve a diagnosis by following a sequence of steps, such as laboratory exams, observations, or imaging. The pathways to reach diagnosis decisions are documented by guidelines authored by expert organizations, which…

Computation and Language · Computer Science 2024-09-25 Elisa Castagnari , Lillian Muyama , Adrien Coulet

The automation of chemical research through self-driving laboratories (SDLs) promises to accelerate scientific discovery, yet the reliability and granular performance of the underlying AI agents remain critical, under-examined challenges.…

Artificial Intelligence · Computer Science 2025-10-01 Gihan Panapitiya , Emily Saldanha , Heather Job , Olivia Hess

Fine-tuning large language models (LLMs) with domain-specific instructions has emerged as an effective method to enhance their domain-specific understanding. Yet, there is limited work that examines the core characteristics acquired during…

Computation and Language · Computer Science 2023-12-27 Varun Nathan , Ayush Kumar , Digvijay Ingle , Jithendra Vepa

The increasing complexity of modern chemical processes, coupled with workforce shortages and intricate fault scenarios, demands novel automation paradigms that blend symbolic reasoning with adaptive control. In this work, we introduce a…

Artificial Intelligence · Computer Science 2025-07-11 Javal Vyas , Mehmet Mercangoz

The paper aims to fulfil three main functions: (1) to serve as an introduction for the physics education community to the functioning of Large Language Models (LLMs), (2) to present a series of illustrative examples demonstrating how…

Physics Education · Physics 2024-01-31 Giulia Polverini , Bor Gregorcic

Computational materials science and chemistry span vast knowledge domains and fractured software ecosystems. Although large language models (LLMs) have demonstrated research capabilities, scaling monolithic agents to manage the rigor and…

Integrating Large Language Models (LLMs) into complex software systems enables the generation of human-understandable explanations of opaque AI processes, such as automated task planning. However, the quality and reliability of these…

Artificial Intelligence · Computer Science 2026-04-24 Gricel Vázquez , Alexandros Evangelidis , Sepeedeh Shahbeigi , Radu Calinescu , Simos Gerasimou

We present a modular framework powered by large language models (LLMs) that automates and streamlines key tasks across the early-stage computational drug discovery pipeline. By combining LLM reasoning with domain-specific tools, the…

Recent research has highlighted the potential of large language models (LLMs) to improve their problem-solving capabilities with the aid of suitable external tools. In our work, we further advance this concept by introducing a closed-loop…

Machine Learning · Computer Science 2024-03-12 Tianle Cai , Xuezhi Wang , Tengyu Ma , Xinyun Chen , Denny Zhou

Complex table question answering (TQA) aims to answer questions that require complex reasoning, such as multi-step or multi-category reasoning, over data represented in tabular form. Previous approaches demonstrated notable performance by…

Computation and Language · Computer Science 2025-02-11 Wei Zhou , Mohsen Mesgar , Annemarie Friedrich , Heike Adel

Large language models (LLMs) have demonstrated significant potential to accelerate scientific discovery as valuable tools for analyzing data, generating hypotheses, and supporting innovative approaches in various scientific fields. In this…

Computation and Language · Computer Science 2025-10-30 Jin Huang , Silviu Cucerzan , Sujay Kumar Jauhar , Ryen W. White

Precisely understanding users' contextual search intent has been an important challenge for conversational search. As conversational search sessions are much more diverse and long-tailed, existing methods trained on limited data still show…

Information Retrieval · Computer Science 2023-10-23 Kelong Mao , Zhicheng Dou , Fengran Mo , Jiewen Hou , Haonan Chen , Hongjin Qian