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Proton therapy offers superior organ-at-risk sparing but is highly sensitive to anatomical changes, making accurate deformable image registration (DIR) across longitudinal CT scans essential. Conventional DIR methods are often too slow for…

In adaptive radiotherapy, deformable image registration is often conducted between the planning CT and treatment CT (or cone beam CT) to generate a deformation vector field (DVF) for dose accumulation and contour propagation. The auto…

Medical Physics · Physics 2015-06-12 Xuejun Gu , Bin Dong , Jing Wang , John Yordy , Loren Mell , Xun Jia , Steve B. Jiang

Background and Purpose: Voxel-based analysis (VBA) helps to identify dose-sensitive regions by aligning individual dose distributions within a common coordinate system (CCS). Accurate deformable image registration (DIR) is essential for…

Medical Physics · Physics 2025-09-26 Xingyue Ruan , Xia Li , Muheng Li , Barbara Bachtiary , Antony Lomax , Zhiling Chen , Ye Zhang

Image registration aims to establish spatial correspondence across pairs, or groups of images, and is a cornerstone of medical image computing and computer-assisted-interventions. Currently, most deep learning-based registration methods…

Image and Video Processing · Electrical Eng. & Systems 2021-07-12 Xiang Chen , Nishant Ravikumar , Yan Xia , Alejandro F Frangi

Cone-beam CT (CBCT)-based online adaptive radiotherapy calls for accurate auto-segmentation to reduce the time cost for physicians to edit contours. However, deep learning (DL)-based direct segmentation of CBCT images is a challenging task,…

Medical Physics · Physics 2023-02-22 Xiao Liang , Howard Morgan , Ti Bai , Michael Dohopolski , Dan Nguyen , Steve Jiang

Regularization is essential in deformable image registration (DIR) to ensure that the estimated Deformation Vector Field (DVF) remains smooth, physically plausible, and anatomically consistent. However, fine-tuning regularization parameters…

Computer Vision and Pattern Recognition · Computer Science 2025-07-18 Sidaty El Hadramy , Oumeymah Cherkaoui , Philippe C. Cattin

Motion information from 4D medical imaging offers critical insights into dynamic changes in patient anatomy for clinical assessments and radiotherapy planning and, thereby, enhances the capabilities of 3D image analysis. However, inherent…

Computer Vision and Pattern Recognition · Computer Science 2025-08-11 Xia Li , Runzhao Yang , Xiangtai Li , Antony Lomax , Ye Zhang , Joachim Buhmann

Deformable image registration (DIR) is a cornerstone of medical image analysis, enabling spatial alignment for tasks like comparative studies and multi-modal fusion. While learning-based methods (e.g., CNNs, transformers) offer fast…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Nikita Drozdov , Marat Zinovev , Dmitry Sorokin

Four-dimensional MRI (4D-MRI) is an promising technique for capturing respiratory-induced motion in radiation therapy planning and delivery. Conventional 4D reconstruction methods, which typically rely on phase binning or separate template…

Computer Vision and Pattern Recognition · Computer Science 2025-09-24 Xinyang Wu , Muheng Li , Xia Li , Orso Pusterla , Sairos Safai , Philippe C. Cattin , Antony J. Lomax , Ye Zhang

Objective: Dynamic cone-beam CT (CBCT) imaging is highly desired in image-guided radiation therapy to provide volumetric images with high spatial and temporal resolutions to enable applications including tumor motion tracking/prediction and…

Medical Physics · Physics 2023-02-22 You Zhang , Tielige Mengke

Objective: Quantify geometric and dosimetric accuracy of a novel prostate MR-to-MR deformable image registration (DIR) approach to support MR-guided adaptive radiation therapy dose accumulation. Approach: We evaluated DIR accuracy in 25…

Longitudinal image registration enables studying temporal changes in brain morphology which is useful in applications where monitoring the growth or atrophy of specific structures is important. However this task is challenging due to;…

Computer Vision and Pattern Recognition · Computer Science 2025-04-15 Aisha L. Shuaibu , Kieran A. Gibb , Peter A. Wijeratne , Ivor J. A. Simpson

Understanding the movement of the left ventricle myocardium (LVmyo) during the cardiac cycle is essential for assessing cardiac function. One way to model this movement is through a series of deformable image registrations (DIRs) of the…

Image and Video Processing · Electrical Eng. & Systems 2025-01-14 Mathias Micheelsen Lowes , Jonas Jalili Pedersen , Bjørn S. Hansen , Klaus Fuglsang Kofoed , Maxime Sermesant , Rasmus R. Paulsen

Objective: Clinical implementation of deformable image registration (DIR) requires voxel-based spatial accuracy metrics such as manually identified landmarks, which are challenging to implement for highly mobile gastrointestinal (GI)…

Recent successes in deep learning based deformable image registration (DIR) methods have demonstrated that complex deformation can be learnt directly from data while reducing computation time when compared to traditional methods. However,…

Computer Vision and Pattern Recognition · Computer Science 2019-08-20 Sharib Ali , Jens Rittscher

Deformable image registration (DIR) is essential for many image-guided therapies. Recently, deep learning approaches have gained substantial popularity and success in DIR. Most deep learning approaches use the so-called mono-stream…

Image and Video Processing · Electrical Eng. & Systems 2020-12-08 Zhe Xu , Jie Luo , Jiangpeng Yan , Xiu Li , Jagadeesan Jayender

Deep learning (DL) has led to significant improvements in medical image synthesis, enabling advanced image-to-image translation to generate synthetic images. However, DL methods face challenges such as domain shift and high demands for…

Image and Video Processing · Electrical Eng. & Systems 2024-02-20 Savannah P. Hays , Lianrui Zuo , Yihao Liu , Anqi Feng , Jiachen Zhuo , Jerry L. Prince , Aaron Carass

Medical image registration is a challenging task involving the estimation of spatial transformations to establish anatomical correspondence between pairs or groups of images. Recently, deep learning-based image registration methods have…

Computer Vision and Pattern Recognition · Computer Science 2022-11-28 Xiang Chen , Yan Xia , Nishant Ravikumar , Alejandro F Frangi

Diffusion tensor cardiac magnetic resonance (DT-CMR) is a method capable of providing non-invasive measurements of myocardial microstructure. Image registration is essential to correct image shifts due to intra and inter breath-hold motion…

Image and Video Processing · Electrical Eng. & Systems 2024-05-17 Fanwen Wang , Pedro F. Ferreira , Yinzhe Wu , Camila Munoz , Ke Wen , Yaqing Luo , Jiahao Huang , Dudley J. Pennell , Andrew D. Scott , Sonia Nielles-Vallespin , Guang Yang

Objective: In medical imaging, it is often crucial to accurately assess and correct movement during image-guided therapy. Deformable image registration (DIR) consists in estimating the required spatial transformation to align a moving image…

Computer Vision and Pattern Recognition · Computer Science 2024-05-22 Eloïse Inacio , Luc Lafitte , Laurent Facq , Clair Poignard , Baudouin Denis de Senneville
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