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In a clustered observational study, a treatment is assigned to groups and all units within the group are exposed to the treatment. We develop a new method for statistical adjustment in clustered observational studies using approximate…

Methodology · Statistics 2023-03-06 Luke Keele , Eli Ben-Michael , Lindsay Page

Clustering in stationary and nonstationary settings, where data distributions remain static or evolve over time, requires models that can adapt to distributional shifts while preserving previously learned cluster structures. This paper…

Machine Learning · Computer Science 2025-12-09 Naoki Masuyama , Yuichiro Toda , Yusuke Nojima , Hisao Ishibuchi

Meta-analyses frequently include trials that report multiple effect sizes based on a common set of study participants. These effect sizes will generally be correlated. Cluster-robust variance-covariance estimators are a fruitful approach…

Methodology · Statistics 2022-03-07 Thilo Welz , Wolfgang Viechtbauer , Markus Pauly

Computerized Adaptive Testing (CAT) is a widely used technology for evaluating learners' proficiency in online education platforms. By leveraging prior estimates of proficiency to select questions and updating the estimates iteratively…

Information Retrieval · Computer Science 2025-12-24 Mi Tian , Kun Zhang , Fei Liu , Jinglong Li , Yuxin Liao , Chenxi Bai , Zhengtao Tan , Le Wu , Richang Hong

We recently developed a new method riAFT-BART to draw causal inferences about population treatment effect on patient survival from clustered and censored survival data while accounting for the multilevel data structure. The practical…

Methodology · Statistics 2023-08-14 Liangyuan Hu

The primary goal of randomized trials is to compare the effects of different interventions on some outcome of interest. In addition to the treatment assignment and outcome, data on baseline covariates, such as demographic characteristics or…

Applications · Statistics 2014-01-09 Alisa J. Stephens , Eric J. Tchetgen Tchetgen , Victor De Gruttola

Clustering is a widely used unsupervised learning technique involving an intensive discrete optimization problem. Associative Memory models or AMs are differentiable neural networks defining a recursive dynamical system, which have been…

Machine Learning · Computer Science 2023-06-07 Bishwajit Saha , Dmitry Krotov , Mohammed J. Zaki , Parikshit Ram

Cluster-randomized trials (CRTs) are experimental designs where groups or clusters of participants, rather than the individual participants themselves, are randomized to intervention groups. Analyzing CRT requires distinguishing between…

Methodology · Statistics 2025-10-10 Xi Fang , Bingkai Wang , Liangyuan Hu , Fan Li

Adapting to latent confounded shift remains a core challenge in modern AI. This setting is driven by hidden variables that induce spurious correlations between inputs and outputs during training, leading models to rely on non-causal…

Machine Learning · Computer Science 2026-05-14 Jialin Yu , Yuxiang Zhou , Haoxuan Li , Junchi Yu , Mengyue Yang , Yulan He , Nevin L. Zhang , Philip Torr , Ricardo Silva

In conventional randomized controlled trials, adjustment for baseline values of covariates known to be at least moderately associated with the outcome increases the power of the trial. Recent work has shown particular benefit for more…

Methodology · Statistics 2023-11-27 James Willard , Shirin Golchi , Erica EM Moodie

Computerized adaptive tests (CATs) play a crucial role in educational assessment and diagnostic screening in behavioral health. Unlike traditional linear tests that administer a fixed set of pre-assembled items, CATs adaptively tailor the…

Methodology · Statistics 2026-05-11 Jiguang Li , Robert Gibbons , Veronika Rockova

Across research disciplines, cluster randomized trials (CRTs) are commonly implemented to evaluate interventions delivered to groups of participants, such as communities and clinics. Despite advances in the design and analysis of CRTs,…

Driving a system from one state to another through targeted interventions is a fundamental challenge in science, yet most predictive models offer limited mechanistic insight and no principled framework for decision-making. Here we present…

Machine Learning · Computer Science 2026-05-29 Zixuan Song , Uwe Mueller , Dimitris V. Manatakis

Three state-of-the-art adaptive population control strategies (PCS) are theoretically and empirically investigated for a multi-recombinative, cumulative step-size adaptation Evolution Strategy $(\mu/\mu_I, \lambda)$-CSA-ES. First, scaling…

Neural and Evolutionary Computing · Computer Science 2024-10-02 Amir Omeradzic , Hans-Georg Beyer

It is generally appreciated that a frequentist analysis of a group sequential trial must in order to avoid inflating type I error account for the fact that one or more interim analyses were performed. It is also to a lesser extent realised…

Methodology · Statistics 2025-12-12 Simon Bang Kristensen , Erik Thorlund Parner

Background: Stepped wedge cluster randomized trials (SW-CRTs) involve sequential measurements within clusters over time. Initially, all clusters start in the control condition before crossing over to the intervention on a staggered…

Methodology · Statistics 2026-01-21 Jale Basten , Katja Ickstadt , Nina Timmesfeld

Heterogeneous treatment effect estimation in high-stakes applications demands models that simultaneously optimize precision, interpretability, and calibration. Many existing tree-based causal inference techniques, however, exhibit high…

Machine Learning · Computer Science 2025-04-21 Yichen Liu

Explainable Artificial Intelligence (XAI) is essential for the transparency and clinical adoption of Clinical Decision Support Systems (CDSS). However, the real-world effectiveness of existing XAI methods remains limited and is…

Machine Learning · Computer Science 2026-01-26 Alessandro Gambetti , Qiwei Han , Hong Shen , Claudia Soares

Like k-means and Gaussian Mixture Model (GMM), fuzzy c-means (FCM) with soft partition has also become a popular clustering algorithm and still is extensively studied. However, these algorithms and their variants still suffer from some…

Machine Learning · Computer Science 2020-04-28 Yunxia Lin , Songcan Chen

There has been significant attention given to developing data-driven methods for tailoring patient care based on individual patient characteristics. Dynamic treatment regimes formalize this through a sequence of decision rules that map…

Methodology · Statistics 2022-02-22 Eric J. Rose , Erica E. M. Moodie , Susan Shortreed