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Multimodal AI models have achieved impressive performance in tasks that require integrating information from multiple modalities, such as vision and language. However, their "black-box" nature poses a major barrier to deployment in…

Artificial Intelligence · Computer Science 2026-02-18 Zhanliang Wang , Kai Wang

Predicting in-hospital mortality for intensive care unit (ICU) patients is key to final clinical outcomes. AI has shown advantaged accuracy but suffers from the lack of explainability. To address this issue, this paper proposes an…

Machine Learning · Computer Science 2024-01-01 Xingqiao Li , Jindong Gu , Zhiyong Wang , Yancheng Yuan , Bo Du , Fengxiang He

Osteoporosis is a common condition that increases fracture risk, especially in older adults. Early diagnosis is vital for preventing fractures, reducing treatment costs, and preserving mobility. However, healthcare providers face challenges…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Mehdi Hosseini Chagahi , Saeed Mohammadi Dashtaki , Niloufar Delfan , Nadia Mohammadi , Farshid Rostami Pouria , Behzad Moshiri , Md. Jalil Piran , Oliver Faust

Deep-learning-based clinical decision support using structured electronic health records (EHR) has been an active research area for predicting risks of mortality and diseases. Meanwhile, large amounts of narrative clinical notes provide…

Computation and Language · Computer Science 2023-05-10 Weimin Lyu , Xinyu Dong , Rachel Wong , Songzhu Zheng , Kayley Abell-Hart , Fusheng Wang , Chao Chen

Purpose: Hard-to-interpret Black-box Machine Learning (ML) were often used for early Alzheimer's Disease (AD) detection. Methods: To interpret eXtreme Gradient Boosting (XGBoost), Random Forest (RF), and Support Vector Machine (SVM)…

Machine Learning · Computer Science 2022-11-08 Louise Bloch , Christoph M. Friedrich

Because of their strong theoretical properties, Shapley values have become very popular as a way to explain predictions made by black box models. Unfortuately, most existing techniques to compute Shapley values are computationally very…

Machine Learning · Computer Science 2022-08-29 Arne Gevaert , Yvan Saeys

Shapley values have several desirable, theoretically well-supported, properties for explaining black-box model predictions. Traditionally, Shapley values are computed post-hoc, leading to additional computational cost at inference time. To…

Machine Learning · Computer Science 2025-07-16 Amr Alkhatib , Roman Bresson , Henrik Boström , Michalis Vazirgiannis

Model averaging techniques in the actuarial literature aim to forecast future longevity appropriately by combining forecasts derived from various models. This approach often yields more accurate predictions than those generated by a single…

Applications · Statistics 2025-10-28 Giovanna Bimonte , Maria Russolillo , Han Lin Shang , Yang Yang

Purpose: Hip fractures are a common cause of morbidity and mortality. Automatic identification and classification of hip fractures using deep learning may improve outcomes by reducing diagnostic errors and decreasing time to operation.…

It is becoming increasingly important to explain complex, black-box machine learning models. Although there is an expanding literature on this topic, Shapley values stand out as a sound method to explain predictions from any type of machine…

Machine Learning · Statistics 2020-07-03 Annabelle Redelmeier , Martin Jullum , Kjersti Aas

Artificial Intelligence techniques can be used to classify a patient's physical activities and predict vital signs for remote patient monitoring. Regression analysis based on non-linear models like deep learning models has limited…

Artificial Intelligence · Computer Science 2024-10-28 Thanveer Shaik , Xiaohui Tao , Haoran Xie , Lin Li , Juan D. Velasquez , Niall Higgins

Major postoperative complications are devastating to surgical patients. Some of these complications are potentially preventable via early predictions based on intraoperative data. However, intraoperative data comprise long and fine-grained…

Machine Learning · Computer Science 2022-10-11 Dingwen Li , Bing Xue , Christopher King , Bradley Fritz , Michael Avidan , Joanna Abraham , Chenyang Lu

The multimodal model has demonstrated promise in histopathology. However, most multimodal models are based on H\&E and genomics, adopting increasingly complex yet black-box designs. In our paper, we propose a novel interpretable multimodal…

Computer Vision and Pattern Recognition · Computer Science 2024-10-03 Jun Wang , Yu Mao , Nan Guan , Chun Jason Xue

The vast majority of research on explainability focuses on post-explainability rather than explainable modeling. Namely, an explanation model is derived to explain a complex black box model built with the sole purpose of achieving the…

Machine Learning · Computer Science 2020-02-14 Gabriel Terejanu , Jawad Chowdhury , Rezaur Rashid , Asif Chowdhury

Risk scores are widely used for clinical decision making and commonly generated from logistic regression models. Machine-learning-based methods may work well for identifying important predictors, but such 'black box' variable selection…

Machine Learning · Computer Science 2024-12-31 Yilin Ning , Siqi Li , Marcus Eng Hock Ong , Feng Xie , Bibhas Chakraborty , Daniel Shu Wei Ting , Nan Liu

Shapley values are widely used to explain black-box models, but they are costly to calculate because they require many model evaluations. We introduce FastSHAP, a method for estimating Shapley values in a single forward pass using a learned…

Machine Learning · Statistics 2022-03-24 Neil Jethani , Mukund Sudarshan , Ian Covert , Su-In Lee , Rajesh Ranganath

In healthcare, making the best possible predictions with complex models (e.g., neural networks, ensembles/stacks of different models) can impact patient welfare. In order to make these complex models explainable, we present DeepSHAP for…

Machine Learning · Computer Science 2019-11-28 Hugh Chen , Scott Lundberg , Su-In Lee

A well-established insight in mortality forecasting is that combining predictions from a set of models improves accuracy compared to relying on a single best model. This paper proposes a novel ensemble approach based on Shapley values, a…

Applications · Statistics 2026-03-05 G. Bimonte , M. Russolillo , Y. Yang , H. L. Shang

Mortality prediction in intensive care units is considered one of the critical steps for efficiently treating patients in serious condition. As a result, various prediction models have been developed to address this problem based on modern…

Machine Learning · Computer Science 2020-12-15 Huachuan Wang , Yuanfei Bi

We introduce a variable importance measure to quantify the impact of individual input variables to a black box function. Our measure is based on the Shapley value from cooperative game theory. Many measures of variable importance operate by…

Machine Learning · Computer Science 2020-10-05 Masayoshi Mase , Art B. Owen , Benjamin Seiler
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