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Current medical retrieval benchmarks primarily emphasize lexical or shallow semantic similarity, overlooking the reasoning-intensive demands that are central to clinical decision-making. In practice, physicians often retrieve authoritative…

Information Retrieval · Computer Science 2026-04-07 Xiangxu Zhang , Lei Li , Xiao Zhou , Zheng Liu

Large language models (LLMs) have demonstrated significant potential in enhancing dense retrieval through query augmentation. However, most existing methods treat the LLM and the retriever as separate modules, overlooking the alignment…

Information Retrieval · Computer Science 2025-05-30 Sijia Yao , Pengcheng Huang , Zhenghao Liu , Yu Gu , Yukun Yan , Shi Yu , Ge Yu

There has been an influx of biomedical domain-specific language models, showing language models pre-trained on biomedical text perform better on biomedical domain benchmarks than those trained on general domain text corpora such as…

Computation and Language · Computer Science 2020-10-15 Hoo-Chang Shin , Yang Zhang , Evelina Bakhturina , Raul Puri , Mostofa Patwary , Mohammad Shoeybi , Raghav Mani

Retrieval-Augmented Generation (RAG) offers a well-established path to grounding large language model (LLM) outputs in external knowledge, yet the question of which retrieval strategy works best in a high-stakes domain such as biomedicine…

Computation and Language · Computer Science 2026-05-05 Devi Prasad Bal , Subhashree Puhan

Large Language Models (LLMs) have demonstrated a remarkable potential in medical knowledge acquisition and question-answering. However, LLMs can potentially hallucinate and yield factually incorrect outcomes, even with domain-specific…

Computation and Language · Computer Science 2024-07-01 Junda Wang , Zhichao Yang , Zonghai Yao , Hong Yu

Electronic Health Records (EHRs) are pivotal in clinical practices, yet their retrieval remains a challenge mainly due to semantic gap issues. Recent advancements in dense retrieval offer promising solutions but existing models, both…

Information Retrieval · Computer Science 2025-07-25 Zhengyun Zhao , Huaiyuan Ying , Yue Zhong , Sheng Yu

Embedding models have become essential for retrieval-augmented generation (RAG) tasks, semantic clustering, and text re-ranking. But despite their growing use, many of these come with notable limitations. For example, Jina fails to capture…

Information Retrieval · Computer Science 2025-05-21 Anand Selvadurai , Jasheen Shaik , Girish Chandrasekar , ShriRadhaKrishnan Balamurugan , Eswara Reddy

Publications in the life sciences are characterized by a large technical vocabulary, with many lexical and semantic variations for expressing the same concept. Towards addressing the problem of relevance in biomedical literature search, we…

Information Retrieval · Computer Science 2018-03-01 Sunil Mohan , Nicolas Fiorini , Sun Kim , Zhiyong Lu

Information retrieval involves selecting artifacts from a corpus that are most relevant to a given search query. The flavor of retrieval typically used in classical applications can be termed as homogeneous and relaxed, where queries and…

Information Retrieval · Computer Science 2023-10-10 Anirudh Khatry , Yasharth Bajpai , Priyanshu Gupta , Sumit Gulwani , Ashish Tiwari

Biomedical data is inherently multimodal, comprising physical measurements and natural language narratives. A generalist biomedical AI model needs to simultaneously process different modalities of data, including text and images. Therefore,…

Background: Biomedical language models should improve performance on biomedical text while retaining general-domain language ability. For Mamba-based models, this trade-off has not been clearly studied across biomedical literature and…

Computation and Language · Computer Science 2026-03-19 Ling Yue , Mingzhi Zhu , Sixue Xing , Shaowu Pan , Vijil Chenthamarakshan , Yanbo Wang , Yunning Cao , Payel Das , Tianfan Fu

Text embedding models play a cornerstone role in AI applications, such as retrieval-augmented generation (RAG). While general-purpose text embedding models demonstrate strong performance on generic retrieval benchmarks, their effectiveness…

Information Retrieval · Computer Science 2025-10-22 Yubai Wei , Jiale Han , Yi Yang

Dense retrieval calls for discriminative embeddings to represent the semantic relationship between query and document. It may benefit from the using of large language models (LLMs), given LLMs' strong capability on semantic understanding.…

Computation and Language · Computer Science 2025-11-25 Zheng Liu , Chaofan Li , Shitao Xiao , Yingxia Shao , Defu Lian

To advance biomedical vison-language model capabilities through scaling up, fine-tuning, and instruction tuning, develop vision-language models with improved performance in handling long text, explore strategies to efficiently adopt vision…

Artificial Intelligence · Computer Science 2025-05-26 Cheng Peng , Kai Zhang , Mengxian Lyu , Hongfang Liu , Lichao Sun , Yonghui Wu

In this paper we present Large Language Model Assisted Retrieval Model Ranking (LARMOR), an effective unsupervised approach that leverages LLMs for selecting which dense retriever to use on a test corpus (target). Dense retriever selection…

Information Retrieval · Computer Science 2024-05-24 Ekaterina Khramtsova , Shengyao Zhuang , Mahsa Baktashmotlagh , Guido Zuccon

Large language models (LLMs) are trained on text-only data that go far beyond the languages with paired speech and text data. At the same time, Dual Encoder (DE) based retrieval systems project queries and documents into the same embedding…

Computation and Language · Computer Science 2024-07-11 Frank Palma Gomez , Ramon Sanabria , Yun-hsuan Sung , Daniel Cer , Siddharth Dalmia , Gustavo Hernandez Abrego

Biomedical question-answering (QA) systems require effective retrieval and generation components to ensure accuracy, efficiency, and scalability. This study systematically examines a Retrieval-Augmented Generation (RAG) system for…

Information Retrieval · Computer Science 2026-01-14 Linus Stuhlmann , Michael Alexander Saxer , Jonathan Fürst

Large Language Models (LLMs) have demonstrated remarkable versatility in recent years, offering potential applications across specialized domains such as healthcare and medicine. Despite the availability of various open-source LLMs tailored…

Computation and Language · Computer Science 2024-07-18 Yanis Labrak , Adrien Bazoge , Emmanuel Morin , Pierre-Antoine Gourraud , Mickael Rouvier , Richard Dufour

The current generation of large language models (LLMs) is typically designed for broad, general-purpose applications, while domain-specific LLMs, especially in vertical fields like medicine, remain relatively scarce. In particular, the…

Recent research demonstrates the effectiveness of using fine-tuned language models~(LM) for dense retrieval. However, dense retrievers are hard to train, typically requiring heavily engineered fine-tuning pipelines to realize their full…

Information Retrieval · Computer Science 2021-08-13 Luyu Gao , Jamie Callan