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Recent advancements in retrieval-augmented generation (RAG) have significantly enhanced the ability of large language models (LLMs) to perform complex question-answering (QA) tasks. In this paper, we introduce MedBioRAG, a…

Computation and Language · Computer Science 2025-12-15 Seonok Kim

While large language models (LLMs) are increasingly deployed as dense retrievers, the impact of their domain-specific specialization on retrieval effectiveness remains underexplored. This investigation systematically examines how…

Information Retrieval · Computer Science 2025-08-07 Hengran Zhang , Keping Bi , Jiafeng Guo

Large language models (LLMs) are incredible and versatile tools for text-based tasks that have enabled countless, previously unimaginable, applications. Retrieval models, in contrast, have not yet seen such capable general-purpose models…

Information Retrieval · Computer Science 2025-09-10 Julian Killingback , Hamed Zamani

With the rapid advancement of multimodal information retrieval, increasingly complex retrieval tasks have emerged. Existing methods predominately rely on task-specific fine-tuning of vision-language models, often those trained with…

Computer Vision and Pattern Recognition · Computer Science 2024-12-03 Yikun Liu , Pingan Chen , Jiayin Cai , Xiaolong Jiang , Yao Hu , Jiangchao Yao , Yanfeng Wang , Weidi Xie

Vision-and-language multi-modal pretraining and fine-tuning have shown great success in visual question answering (VQA). Compared to general domain VQA, the performance of biomedical VQA suffers from limited data. In this paper, we propose…

Computer Vision and Pattern Recognition · Computer Science 2023-03-02 Zheng Yuan , Qiao Jin , Chuanqi Tan , Zhengyun Zhao , Hongyi Yuan , Fei Huang , Songfang Huang

Large Language Models (LLMs), particularly those similar to ChatGPT, have significantly influenced the field of Natural Language Processing (NLP). While these models excel in general language tasks, their performance in domain-specific…

Computation and Language · Computer Science 2024-01-02 Omid Rohanian , Mohammadmahdi Nouriborji , David A. Clifton

Motivation: State-of-the-art biomedical named entity recognition (BioNER) systems often require handcrafted features specific to each entity type, such as genes, chemicals and diseases. Although recent studies explored using neural network…

Information Retrieval · Computer Science 2018-10-09 Xuan Wang , Yu Zhang , Xiang Ren , Yuhao Zhang , Marinka Zitnik , Jingbo Shang , Curtis Langlotz , Jiawei Han

Recent advances in large language models (LLMs) have made significant progress across multiple biomedical tasks, including biomedical question answering, lay-language summarization of the biomedical literature, and clinical note…

Information Retrieval · Computer Science 2026-03-24 Deepak Gupta , Dina Demner-Fushman , William Hersh , Steven Bedrick , Kirk Roberts

Despite the success of large language models (LLMs) on general-purpose tasks, their performance in highly specialized domains such as biomedicine remains unsatisfactory. A key limitation is the inability of LLMs to effectively leverage…

Computation and Language · Computer Science 2026-05-08 Xin Gao , Ruiyi Zhang , Meixi Du , Peijia Qin , Pengtao Xie

Retrieving relevant contexts from a large corpus is a crucial step for tasks such as open-domain question answering and fact checking. Although neural retrieval outperforms traditional methods like tf-idf and BM25, its performance degrades…

Computation and Language · Computer Science 2021-01-05 Jean Maillard , Vladimir Karpukhin , Fabio Petroni , Wen-tau Yih , Barlas Oğuz , Veselin Stoyanov , Gargi Ghosh

Retrieval-augmented generation (RAG) has become the backbone of grounding Large Language Models (LLMs), improving knowledge updates and reducing hallucinations. Recently, LLM-based retriever models have shown state-of-the-art performance…

Information retrieval systems are crucial for enabling effective access to large document collections. Recent approaches have leveraged Large Language Models (LLMs) to enhance retrieval performance through query augmentation, but often rely…

Information Retrieval · Computer Science 2025-04-15 Pengcheng Jiang , Jiacheng Lin , Lang Cao , Runchu Tian , SeongKu Kang , Zifeng Wang , Jimeng Sun , Jiawei Han

Recently, Large Language Models (LLM) have demonstrated impressive capability to solve a wide range of tasks. However, despite their success across various tasks, no prior work has investigated their capability in the biomedical domain yet.…

Computation and Language · Computer Science 2024-02-21 Israt Jahan , Md Tahmid Rahman Laskar , Chun Peng , Jimmy Huang

Despite their strong linguistic capabilities, Large Language Models (LLMs) are computationally demanding and require substantial resources for fine-tuning, which is unadapted to privacy and budget constraints of many healthcare settings. To…

Computation and Language · Computer Science 2026-04-30 Pierre Epron , Adrien Coulet , Mehwish Alam

In this demo we present a web-based application for selecting an effective pre-trained dense retriever to use on a private collection. Our system, DenseQuest, provides unsupervised selection and ranking capabilities to predict the best…

Information Retrieval · Computer Science 2024-07-10 Ekaterina Khramtsova , Teerapong Leelanupab , Shengyao Zhuang , Mahsa Baktashmotlagh , Guido Zuccon

Retrieval-Augmented Generation (RAG) is a powerful technique for enriching Large Language Models (LLMs) with external knowledge, allowing for factually grounded responses, a critical requirement in high-stakes domains such as healthcare.…

Computation and Language · Computer Science 2025-10-07 Eduardo Martínez Rivera , Filippo Menolascina

The application of large language models (LLMs) to healthcare information extraction has emerged as a promising approach. This study evaluates the classification performance of five open-source LLMs: GEMMA-3-27B-IT, LLAMA3-70B, LLAMA4-109B,…

Computation and Language · Computer Science 2025-05-09 Yuting Guo , Abeed Sarker

Multilingual dense retrieval aims to retrieve relevant documents across different languages based on a unified retriever model. The challenge lies in aligning representations of different languages in a shared vector space. The common…

Information Retrieval · Computer Science 2025-09-12 Chao Huang , Fengran Mo , Yufeng Chen , Changhao Guan , Zhenrui Yue , Xinyu Wang , Jinan Xu , Kaiyu Huang

Effective biomedical information retrieval requires modeling domain semantics and hierarchical relationships among biomedical texts. Existing biomedical generative retrievers build on coarse binary relevance signals, limiting their ability…

Information Retrieval · Computer Science 2026-04-20 Mengfei Lan , Lecheng Zheng , Halil Kilicoglu

To enhance the performance of large language models (LLMs) in biomedical natural language processing (BioNLP) by introducing a domain-specific instruction dataset and examining its impact when combined with multi-task learning principles.…

Computation and Language · Computer Science 2024-06-10 Hieu Tran , Zhichao Yang , Zonghai Yao , Hong Yu