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Deep learning architectures have proved versatile in a number of drug discovery applications, including the modelling of in vitro compound activity. While controlling for prediction confidence is essential to increase the trust,…

Machine Learning · Computer Science 2018-10-23 Isidro Cortes-Ciriano , Andreas Bender

Traditional statistical inference in cluster randomized trials typically invokes the asymptotic theory that requires the number of clusters to approach infinity. In this article, we propose an alternative conformal causal inference…

Methodology · Statistics 2024-10-03 Bingkai Wang , Fan Li , Mengxin Yu

A usual way to model a recommendation system is as a matrix completion problem. There are several matrix completion methods, typically using optimization approaches or collaborative filtering. Most approaches assume that the matrix is…

Information Retrieval · Computer Science 2017-07-20 Guilherme Ramos , Joao Saude , Carlos Caleiro , Soummya Kar

Evaluating treatment effect heterogeneity widely informs treatment decision making. At the moment, much emphasis is placed on the estimation of the conditional average treatment effect via flexible machine learning algorithms. While these…

Methodology · Statistics 2021-05-07 Lihua Lei , Emmanuel J. Candès

In demographic literature, forecast uncertainty is often quantified with a statistical model. This model-based approach may potentially suffer from drawbacks, namely model misspecification, selection effect, and lack of finite-sample…

Applications · Statistics 2026-05-29 Han Lin Shang

Recommender systems (RS), which have been an essential part in a wide range of applications, can be formulated as a matrix completion (MC) problem. To boost the performance of MC, matrix completion with side information, called inductive…

Information Retrieval · Computer Science 2020-02-13 Kai-Lang Yao , Wu-Jun Li

This paper proposes the use of "multicalibration" to yield interpretable and reliable confidence scores for outputs generated by large language models (LLMs). Multicalibration asks for calibration not just marginally, but simultaneously…

Machine Learning · Statistics 2024-04-09 Gianluca Detommaso , Martin Bertran , Riccardo Fogliato , Aaron Roth

Conformal prediction is a popular technique for constructing prediction intervals with distribution-free coverage guarantees. The coverage is marginal, meaning it only holds on average over the entire population but not necessarily for any…

Methodology · Statistics 2026-05-28 Yao Zhang , Emmanuel J. Candès

Conformal prediction is an assumption-lean approach to generating distribution-free prediction intervals or sets, for nearly arbitrary predictive models, with guaranteed finite-sample coverage. Conformal methods are an active research topic…

Methodology · Statistics 2024-01-19 Jerzy Wieczorek

We develop confidence sets which provide spatial uncertainty guarantees for the output of a black-box machine learning model designed for image segmentation. To do so we adapt conformal inference to the imaging setting, obtaining thresholds…

Machine Learning · Statistics 2024-10-10 Samuel Davenport

Matrix completion tackles the task of predicting missing values in a low-rank matrix based on a sparse set of observed entries. It is often assumed that the observation pattern is generated uniformly at random or has a very specific…

Machine Learning · Statistics 2025-03-18 Yudong Chen , Xumei Xi , Christina Lee Yu

Background and objective: Uncertainty quantification is a pivotal field that contributes to realizing reliable and robust systems. It becomes instrumental in fortifying safe decisions by providing complementary information, particularly…

Image and Video Processing · Electrical Eng. & Systems 2024-03-19 Jamil Fayyad , Shadi Alijani , Homayoun Najjaran

Recommender systems aim to enhance the overall user experience by providing tailored recommendations for a variety of products and services. These systems help users make more informed decisions, leading to greater user engagement with the…

Information Retrieval · Computer Science 2024-02-20 Adamya Shyam , Vikas Kumar , Venkateswara Rao Kagita , Arun K Pujari

In real-world settings involving consequential decision-making, the deployment of machine learning systems generally requires both reliable uncertainty quantification and protection of individuals' privacy. We present a framework that…

Machine Learning · Computer Science 2024-03-05 Anastasios N. Angelopoulos , Stephen Bates , Tijana Zrnic , Michael I. Jordan

Standard conformal prediction methods provide a marginal coverage guarantee, which means that for a random test point, the conformal prediction set contains the true label with a user-specified probability. In many classification problems,…

Transformers have become a standard architecture in machine learning, demonstrating strong in-context learning (ICL) abilities that allow them to learn from the prompt at inference time. However, uncertainty quantification for ICL remains…

Machine Learning · Statistics 2025-04-23 Zhe Huang , Simone Rossi , Rui Yuan , Thomas Hannagan

We consider the problem of distribution-free conformal prediction and the criterion of group conditional validity. This criterion is motivated by many practical scenarios including hidden stratification and group fairness. Existing methods…

Machine Learning · Computer Science 2023-03-21 Samuel Deng , Navid Ardeshir , Daniel Hsu

While clustering is ubiquitously used across science and industry, uncertainty in cluster assignments is rarely quantified with rigorous guarantees. We propose a novel conformal inference framework for clustering that returns confidence…

Methodology · Statistics 2026-04-13 YoonHaeng Hur , Anirban Nath , Genevera Allen

Many safety failures in machine learning arise when models are used to assign predictions to people (often in settings like lending, hiring, or content moderation) without accounting for how individuals can change their inputs. In this…

Machine Learning · Computer Science 2025-07-04 Seung Hyun Cheon , Meredith Stewart , Bogdan Kulynych , Tsui-Wei Weng , Berk Ustun

Machine learning can significantly improve performance for decision-making under uncertainty across a wide range of domains. However, ensuring robustness guarantees requires well-calibrated uncertainty estimates, which can be difficult to…

Machine Learning · Computer Science 2026-02-03 Christopher Yeh , Nicolas Christianson , Alan Wu , Adam Wierman , Yisong Yue