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Axons functionally link the somato-dendritic compartment to synaptic terminals. Structurally and functionally diverse, they accomplish a central role in determining the delays and reliability with which neuronal ensembles communicate. By…
The spatial structure of the cell is highly organized at all levels: from small complexes and assemblies, to local nano- and micro-clusters, to global, micrometer scales across and between cells. We suggest that this multiscale spatial cell…
Stigmergy has proved its great superiority in terms of distributed control, robustness and adaptability, thus being regarded as an ideal solution for large-scale swarm control problems. Based on new discoveries on astrocytes in regulating…
The role of gravity is crucial in astrophysics. It determines the evolution of any system, over an enormous range of time and space scales. Astronomical stellar systems as composed by N interacting bodies represent examples of…
Understanding the information processing roles of cortical circuits is an outstanding problem in neuroscience and artificial intelligence. The theoretical setting of Bayesian inference has been suggested as a framework for understanding…
Stars play a key role in the evolution of the Universe, as sources of radiation, as dynamical engines, and as chemical factories. Outputs of stellar models are then central to various studies in astrophysics. Stellar physics links…
To maintain homeostasis, living cells process information with networks of interacting molecules. Traditional models for cellular information processing have focused on networks of chemical reactions between molecules. Here, we describe how…
A computational model incorporating insights from quantum theory is proposed to describe and explain synaptic message transmission. We propose that together, neurotransmitters and their corresponding receptors, function as a physical…
We report the first results of simulating the coupling of neuronal, astrocyte, and cerebrovascular activity. It is suggested that the dynamics of the system is different from systems that only include neurons. In the neuron-vascular…
While there is still a lot to learn about astrocytes and their neuromodulatory role in the spatial and temporal integration of neuronal activity, their introduction to neuromorphic hardware is timely, facilitating their computational…
A new paradigm has recently emerged in brain science whereby communications between glial cells and neuron-glia interactions should be considered together with neurons and their networks to understand higher brain functions. In particular,…
Most of the intra-cellular events involved in the initiation and propagation phases of this process has now been identified astrocytes. The control of the spread of intracellular calcium signaling has been demonstrated to occur at several…
A major goal of modern computational biology is to simulate the collective behaviour of large cell populations starting from the intricate web of molecular interactions occurring at the microscopic level. In this paper we describe a…
Present day computers expend orders of magnitude more computational resources to perform various cognitive and perception related tasks that humans routinely perform everyday. This has recently resulted in a seismic shift in the field of…
Cell signaling, gene expression, and metabolism are affected by cell-cell heterogeneity and random changes in the environment. The effects of such fluctuations on cell signaling and gene expression have recently been studied intensively…
We review modeling of astrocyte ion dynamics with a specific focus on the implications of so-called spatial potassium buffering, where excess potassium in the extracellular space (ECS) is transported away to prevent pathological neural…
A structural relationship between the centrosome and cytoskeleton has been recognized for many years. Centrosomes typically reside near the nucleus, establishing and maintaining the nucleus-centrosome axis. This spatial arrangement is…
The calcium transport in biological systems is modelled as a reaction-diffusion process. Nonlinear calcium waves are then simulated using a stochastic cellular automaton whose rules are derived from the corresponding coupled partial…
Biological cells can exchange messages through soluble molecules or membrane-bound receptors. In particular in the latter case, the interaction is usually located in specific regions of the interacting cells and may depend on or induce…
Inter neuron communication happens through the exchange of neurotransmitters at the synapse by a process known as exocytosis. This makes exocytosis a fundamental process of information exchange in the body. The exocytosis process has a…