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The participation of astrocytes in brain computation was formally hypothesized in 1992, coinciding with the discovery that these glial cells display a complex form of Ca2+ excitability. This fostered conceptual advances centered on the…

Neurons and Cognition · Quantitative Biology 2023-10-23 Ciaran Murphy-Royal , ShiNung Ching , Thomas Papouin

Astrocytes express a large variety of G~protein-coupled receptors (GPCRs) which mediate the transduction of extracellular signals into intracellular calcium responses. This transduction is provided by a complex network of biochemical…

Subcellular Processes · Quantitative Biology 2018-01-23 Maurizio De Pittà , Eshel Ben-Jacob , Hugues Berry

While neuromorphic computing architectures based on Spiking Neural Networks (SNNs) are increasingly gaining interest as a pathway toward bio-plausible machine learning, attention is still focused on computational units like the neuron and…

Neural and Evolutionary Computing · Computer Science 2023-03-10 Zhuangyu Han , A N M Nafiul Islam , Abhronil Sengupta

Modeling the neuronal processes underlying short-term working memory remains the focus of many theoretical studies in neuroscience. Here we propose a mathematical model of spiking neuron network (SNN) demonstrating how a piece of…

Neurons and Cognition · Quantitative Biology 2021-09-01 Yuliya Tsybina , Innokentiy Kastalskiy , Mikhail Krivonosov , Alexey Zaikin , Victor Kazantsev , Alexander Gorban , Susanna Gordleeva

Finding the origin of slow and infra-slow oscillations could reveal or explain brain mechanisms in health and disease. Here, we present a biophysically constrained computational model of a neural network where the inclusion of astrocytes…

Neurons and Cognition · Quantitative Biology 2017-02-15 Leo Kozachkov , Konstantinos P. Michmizos

Astrocytes play a central role in inducing concerted phase synchronized neural-wave patterns inside the brain. In this article, we demonstrate that injected radio-frequency signal in underlying heavy metal layer of spin-orbit torque…

Emerging Technologies · Computer Science 2021-09-17 Umang Garg , Kezhou Yang , Abhronil Sengupta

This paper presents an innovative methodology for improving the robustness and computational efficiency of Spiking Neural Networks (SNNs), a critical component in neuromorphic computing. The proposed approach integrates astrocytes, a type…

Neural and Evolutionary Computing · Computer Science 2023-09-18 Murat Isik , Kayode Inadagbo

Computational chemistry plays a relevant role in many astrochemical research fields, either by complementing experimental measurements or by deriving parameters difficult to be reproduced by laboratories. While the role of computational…

Astrophysics of Galaxies · Physics 2024-09-12 Francesca Tonolo , Silvia Alessandrini

We propose a new mean-field model of brain rhythms governed by astrocytes. This theoretical framework describes how astrocytes can regulate neuronal activity and contribute to the generation of brain rhythms. The model describes at the…

Neurons and Cognition · Quantitative Biology 2024-05-07 Sergey V. Stasenko , Sergey M. Olenin , Eugene A. Grines , Tatiana A. Levanova

Trafficking of glutamate receptors into and out of synapses is critically involved in the plasticity of excitatory synaptic transmission. Endocytosis and exocytosis of receptors have initially been thought to account alone for this…

Optics · Physics 2007-05-23 Laurent Cognet , Laurent Groc , Brahim Lounis , Daniel Choquet

In the brain, both neurons and glial cells work in conjunction with each other during information processing. Stimulation of neurons can cause calcium oscillations in astrocytes which in turn can affect neuronal calcium dynamics. The…

Neurons and Cognition · Quantitative Biology 2023-08-16 Bhanu Sharma , Spandan Kumar , Subhendu Ghosh , Vikram Singh

A mathematical model of a spiking neuron network accompanied by astrocytes is considered. The network is composed of excitatory and inhibitory neurons with synaptic connections supplied by a memristor-based model of plasticity. Another…

Neurons and Cognition · Quantitative Biology 2024-02-27 Sergey V. Stasenko , Alexey N. Mikhaylov , Alexander A. Fedotov , Vladimir A. Smirnov , Victor B. Kazantsev

Brain activities are featured by spatially distributed neural clusters of coherent firings and a spontaneous switching of the clusters between the synchrony and asynchrony states. Evidences from {\it in vivo} experiments suggest that…

Neurons and Cognition · Quantitative Biology 2023-02-02 Ya Wang , Liang Wang , Huawei Fan , Jun Ma , Hui Cao , Xingang Wang

The neuronal paradigm of studying the brain has left us with limitations in both our understanding of how neurons process information to achieve biological intelligence and how such knowledge may be translated into artificial intelligence…

Neurons and Cognition · Quantitative Biology 2020-05-12 Leo Kozachkov , Konstantinos P. Michmizos

The modern study of the dynamics of stellar systems requires the use of high-performance computers. Indeed, an accurate modelization of the structure and evolution of self-gravitating systems like planetary systems, open clusters, globular…

Astrophysics · Physics 2015-06-10 R. Capuzzo-Dolcetta , P. Di Matteo , P. Miocchi

The Integrated Information is a quantitative measure from information theory how tightly all parts of a system are interconnected in terms of information exchange. In this study we show that astrocyte, playing an important role in…

Neurons and Cognition · Quantitative Biology 2019-01-30 Oleg Kanakov , Susanna Gordleeva , Anastasia Ermolaeva , Sarika Jalan , Alexey Zaikin

Traditional artificial neural networks take inspiration from biological networks, using layers of neuron-like nodes to pass information for processing. More realistic models include spiking in the neural network, capturing the electrical…

Machine Learning · Computer Science 2025-03-11 Christopher S. Yang , Sylvester J. Gates , Dulara De Zoysa , Jaehoon Choe , Wolfgang Losert , Corey B. Hart

Mounting evidence in recent years suggests that astrocytes, a sub-type of glial cells, not only serve metabolic and structural support for neurons and synapses but also play critical roles in regulation of proper functioning of the nervous…

Neurons and Cognition · Quantitative Biology 2022-05-18 Tugba Palabas , Andre Longtin , Dibakar Ghosh , Muhammet Uzuntarla

Synaptic Transmission is a multiscale process, revealed by various approaches, going from the molecular to the cellular level. This correspondence points out to our recent contributions in this field. We now provide the physical and…

Neurons and Cognition · Quantitative Biology 2012-02-10 David Holcman

Persistent neural activity underlying working memory requires sustained synaptic transmission, yet the metabolic and neurotransmitter support provided by astrocyte networks is largely absent from spatially extended neural circuit models. We…

Neurons and Cognition · Quantitative Biology 2026-04-14 Noah Palmer , Heather L. Cihak , Daniele Avitabile , Zachary P. Kilpatrick