English
Related papers

Related papers: Revealing data leakage in protein interaction benc…

200 papers

We consider membership inference attacks, one of the main privacy issues in machine learning. These recently developed attacks have been proven successful in determining, with confidence better than a random guess, whether a given sample…

Machine Learning · Computer Science 2019-11-20 Rauf Izmailov , Peter Lin , Chris Mesterharm , Samyadeep Basu

Deep learning has deeply influenced protein science, enabling breakthroughs in predicting protein properties, higher-order structures, and molecular interactions. This paper introduces DeepProtein, a comprehensive and user-friendly deep…

Machine Learning · Computer Science 2025-06-17 Jiaqing Xie , Tianfan Fu

Machine learning algorithms, when applied to sensitive data, pose a distinct threat to privacy. A growing body of prior work demonstrates that models produced by these algorithms may leak specific private information in the training data to…

Cryptography and Security · Computer Science 2018-05-08 Samuel Yeom , Irene Giacomelli , Matt Fredrikson , Somesh Jha

A key obstacle in automated analytics and meta-learning is the inability to recognize when different datasets contain measurements of the same variable. Because provided attribute labels are often uninformative in practice, this task may be…

Machine Learning · Computer Science 2019-09-12 Jonas Mueller , Alex Smola

Large language models achieve high performance on many but not all downstream tasks. The interaction between pretraining data and task data is commonly assumed to determine this variance: a task with data that is more similar to a model's…

Computation and Language · Computer Science 2023-11-16 Gregory Yauney , Emily Reif , David Mimno

Sub-sequence splitting (SSS) has been demonstrated as an effective approach to mitigate data sparsity in sequential recommendation (SR) by splitting a raw user interaction sequence into multiple sub-sequences. Previous studies have…

Information Retrieval · Computer Science 2026-04-08 Yizhou Dang , Yifan Wu , Minhan Huang , Chuang Zhao , Lianbo Ma , Guibing Guo , Xingwei Wang , Zhu Sun

Advances in deep learning have opened an era of abundant and accurate predicted protein structures; however, similar progress in protein ensembles has remained elusive. This review highlights several recent research directions towards…

Biomolecules · Quantitative Biology 2025-09-23 Bowen Jing , Bonnie Berger , Tommi Jaakkola

Split learning is a promising paradigm for privacy-preserving distributed learning. The learning model can be cut into multiple portions to be collaboratively trained at the participants by exchanging only the intermediate results at the…

Machine Learning · Computer Science 2024-03-25 Junlin Liu , Xinchen Lyu , Qimei Cui , Xiaofeng Tao

The capability of accurate prediction of protein functions and properties is essential in the biotechnology industry, e.g. drug development and artificial protein synthesis, etc. The main challenges of protein function prediction are the…

Quantitative Methods · Quantitative Biology 2021-12-02 Wei-Cheng Tseng , Po-Han Chi , Jia-Hua Wu , Min Sun

Emerging applications of machine learning in numerous areas involve continuous gathering of and learning from streams of data. Real-time incorporation of streaming data into the learned models is essential for improved inference in these…

Machine Learning · Computer Science 2020-12-01 Matthew Nokleby , Haroon Raja , Waheed U. Bajwa

Hyperparameters are critical in machine learning, as different hyperparameters often result in models with significantly different performance. Hyperparameters may be deemed confidential because of their commercial value and the…

Cryptography and Security · Computer Science 2019-09-10 Binghui Wang , Neil Zhenqiang Gong

Learning meaningful protein representation is important for a variety of biological downstream tasks such as structure-based drug design. Having witnessed the success of protein sequence pretraining, pretraining for structural data which is…

Machine Learning · Computer Science 2023-02-23 Yufei Huang , Lirong Wu , Haitao Lin , Jiangbin Zheng , Ge Wang , Stan Z. Li

This study critically examines the methodological rigor in credit card fraud detection research, revealing how fundamental evaluation flaws can overshadow algorithmic sophistication. Through deliberate experimentation with improper…

Machine Learning · Computer Science 2025-11-11 Khizar Hayat , Baptiste Magnier

Data-driven approaches such as deep learning can result in predictive models for material properties with exceptional accuracy and efficiency. However, in many applications, data is sparse, severely limiting their accuracy and…

Machine Learning · Computer Science 2025-10-29 Robert J Appleton , Brian C Barnes , Alejandro Strachan

Protein representation learning methods have shown great potential to yield useful representation for many downstream tasks, especially on protein classification. Moreover, a few recent studies have shown great promise in addressing…

Machine Learning · Computer Science 2023-04-11 Can Chen , Jingbo Zhou , Fan Wang , Xue Liu , Dejing Dou

The process of linking databases that contain sensitive information about individuals across organisations is an increasingly common requirement in the health and social science research domains, as well as with governments and businesses.…

Cryptography and Security · Computer Science 2025-05-14 Peter Christen , Rainer Schnell , Anushka Vidanage

Dataset shift is common in credit scoring scenarios, and the inconsistency between the distribution of training data and the data that actually needs to be predicted is likely to cause poor model performance. However, most of the current…

Machine Learning · Computer Science 2021-12-21 Hongyi Qian , Baohui Wang , Ping Ma , Lei Peng , Songfeng Gao , You Song

Proteins perform much of the work in living organisms, and consequently the development of efficient computational methods for protein representation is essential for advancing large-scale biological research. Most current approaches…

Quantitative Methods · Quantitative Biology 2023-06-09 Francesco Ceccarelli , Lorenzo Giusti , Sean B. Holden , Pietro Liò

Ensuring the privacy of research participants is vital, even more so in healthcare environments. Deep learning approaches to neuroimaging require large datasets, and this often necessitates sharing data between multiple sites, which is…

Quantitative Methods · Quantitative Biology 2021-06-04 Umang Gupta , Dimitris Stripelis , Pradeep K. Lam , Paul M. Thompson , José Luis Ambite , Greg Ver Steeg

Machine learning models leak information about their training data every time they reveal a prediction. This is problematic when the training data needs to remain private. Private prediction methods limit how much information about the…

Machine Learning · Computer Science 2020-07-13 Laurens van der Maaten , Awni Hannun