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This paper presents an approach to modeling progressive event-history data when the overall objective is prediction based on time-dependent covariates. This approach does not model the hazard function directly. Instead, it models the…

Methodology · Statistics 2010-09-07 Song Cai , James V. Zidek , Nathaniel Newlands

Molecular phylogenetic and phylogeographic reconstructions generally assume time-homogeneous substitution processes. Motivated by computational convenience, this assumption sacrifices biological realism and offers little opportunity to…

Populations and Evolution · Quantitative Biology 2013-09-13 Filip Bielejec , Philippe Lemey , Guy Baele , Andrew Rambaut , Marc A Suchard

We study a density-dependent Markov jump process describing a population where each individual is characterized by a type, and reproduces at rates depending both on its type and on the population type distribution. We are interested in the…

Probability · Mathematics 2026-02-26 Madeleine Kubasch

Age-dependent dynamics is an important characteristic of many infectious diseases. Age-group epidemic models describe the infection dynamics in different age-groups by allowing to set distinct parameter values for each. However, such models…

Methodology · Statistics 2017-07-17 Rami Yaari , Itai Dattner , Amit Huppert

We consider a continuous-time Markov chain model of SIR disease dynamics with two levels of mixing. For this so-called stochastic households model, we provide two methods for inferring the model parameters---governing within-household…

Populations and Evolution · Quantitative Biology 2018-02-07 James N. Walker , Joshua V. Ross , Andrew J. Black

An interesting inference drawn by some Covid-19 epidemiological models is that there exists a proportion of the population who are not susceptible to infection -- even at the start of the current pandemic. This paper introduces a model of…

Quantitative Methods · Quantitative Biology 2020-09-18 Thomas Parr , Anjali Bhat , Peter Zeidman , Aimee Goel , Alexander J. Billig , Rosalyn Moran , Karl J. Friston

The spread of viruses in biological networks, computer networks, and human contact networks can have devastating effects; developing and analyzing mathematical models of these systems can be insightful and lead to societal benefits. Prior…

Optimization and Control · Mathematics 2016-09-19 Philip E. Paré , Angelia Nedić , Carolyn L. Beck

Mathematical models of infectious diseases, which are in principle analytically tractable, use two general approaches. The first approach, generally known as compartmental modeling, addresses the time evolution of disease propagation at the…

Populations and Evolution · Quantitative Biology 2010-09-16 Pierre-André Noël , Bahman Davoudi , Robert C. Brunham , Louis J. Dubé , Babak Pourbohloul

In the present work, a non-linear stochastic model is presented to study the effect of time variation of transmission rates on the co-evolution of epidemics and its corresponding awareness over a two layered multiplex network. In this…

Physics and Society · Physics 2021-12-08 Vikram Sagar , Yi Zhao , Abhijit Sen

Vaccination campaigns play a pivotal role in controlling infectious diseases. Their success, however, depends not only on vaccine efficacy and availability but also significantly on public opinion and the willingness of individuals to…

Physics and Society · Physics 2026-03-26 Anika Roy , Ujjwal Shekhar , Subrata Ghosh , Tomasz Kapitaniak , Chittaranjan Hens

We consider a Spatial Markov Chain model for the spread of viruses. The model is based on the principle to represent a graph connecting nodes, which represent humans. The vertices between the nodes represent relations between humans. In…

Populations and Evolution · Quantitative Biology 2020-04-14 Fred Vermolen

We introduce and discuss a kinetic framework describing the time evolution of the statistical distributions of a population divided into the compartments of susceptible, infectious, recovered, and resistant in the presence of a microbial…

Populations and Evolution · Quantitative Biology 2026-05-07 Marco Menale , Giuseppe Toscani , Mattia Zanella

The effectiveness of vaccination highly depends on the choice of individuals to vaccinate, even if the same number of individuals are vaccinated. Vaccinating individuals with high centrality measures such as betweenness centrality (BC) and…

Physics and Society · Physics 2021-12-30 Bukyoung Jhun

We adapt the article of Forien, Pang, Pardoux and Zotsa: Arxiv preprint Arxiv2210.04667(2022), on epidemic models with varying infectivity and waning immunity, to incorporate the memory of the last infection. To this end, we introduce a…

Probability · Mathematics 2025-05-02 Hélène Guérin , Arsene Brice Zotsa-Ngoufack

The estimation of absorption time distributions of Markov jump processes is an important task in various branches of statistics and applied probability. While the time-homogeneous case is classic, the time-inhomogeneous case has recently…

Statistics Theory · Mathematics 2022-07-26 Jamaal Ahmad , Martin Bladt , Mogens Bladt

In this paper, we consider statistical estimation of time-inhomogeneous aggregate Markov models. Unaggregated models, which corresponds to Markov chains, are commonly used in multi-state life insurance to model the biometric states of an…

Statistics Theory · Mathematics 2023-08-11 Jamaal Ahmad , Mogens Bladt

Modern health data science applications leverage abundant molecular and electronic health data, providing opportunities for machine learning to build statistical models to support clinical practice. Time-to-event analysis, also called…

Contacts between individuals serve as pathways where infections may propagate. These contact patterns can be represented by network structures. Static structures have been the common modeling paradigm but recent results suggest that…

Populations and Evolution · Quantitative Biology 2012-04-25 Luis Enrique Correa Rocha , Adeline Decuyper , Vincent D Blondel

We introduce the concept of a Markov influence system (MIS) and analyze its dynamics. An MIS models a random walk in a graph whose edges and transition probabilities change endogenously as a function of the current distribution. This…

Multiagent Systems · Computer Science 2019-03-28 Bernard Chazelle

Semi-Markov models are widely used for survival analysis and reliability analysis. In general, there are two competing parameterizations and each entails its own interpretation and inference properties. On the one hand, a semi-Markov…

Methodology · Statistics 2021-01-01 Azam Asanjarani , Benoit Liquet , Yoni Nazarathy