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Prediction uncertainty estimation has clinical significance as it can potentially quantify prediction reliability. Clinicians may trust 'blackbox' models more if robust reliability information is available, which may lead to more models…

Machine Learning · Computer Science 2022-10-04 Michael Dohopolski , Kai Wang , Biling Wang , Ti Bai , Dan Nguyen , David Sher , Steve Jiang , Jing Wang

High-quality labeled data is essential for training robust machine learning models, yet obtaining annotations at scale remains expensive. AI-assisted annotation has therefore become standard in large-scale labeling workflows. However, in…

Human-Computer Interaction · Computer Science 2026-05-13 Moussa Kassem Sbeyti , Joshua Holstein , Philipp Spitzer , Nadja Klein , Gerhard Satzger

Segmentation tasks in medical imaging are inherently ambiguous: the boundary of a target structure is oftentimes unclear due to image quality and biological factors. As such, predicted segmentations from deep learning algorithms are…

Image and Video Processing · Electrical Eng. & Systems 2019-11-18 Katharina Hoebel , Ken Chang , Jay Patel , Praveer Singh , Jayashree Kalpathy-Cramer

Machine-learning-assisted cancer subtyping is a promising avenue in digital pathology. Cancer subtyping models, however, require careful training using expert annotations so that they can be inferred with a degree of known certainty (or…

Convolutional neural networks have shown to achieve superior performance on image segmentation tasks. However, convolutional neural networks, operating as black-box systems, generally do not provide a reliable measure about the confidence…

Computer Vision and Pattern Recognition · Computer Science 2020-07-20 Alexander Treiss , Jannis Walk , Niklas Kühl

Attention guidance is an approach to addressing dataset bias in deep learning, where the model relies on incorrect features to make decisions. Focusing on image classification tasks, we propose an efficient human-in-the-loop system to…

Computer Vision and Pattern Recognition · Computer Science 2023-02-07 Yi He , Xi Yang , Chia-Ming Chang , Haoran Xie , Takeo Igarashi

Medical image segmentation data inherently contain uncertainty. This can stem from both imperfect image quality and variability in labeling preferences on ambiguous pixels, which depend on annotator expertise and the clinical context of the…

Image and Video Processing · Electrical Eng. & Systems 2025-07-17 Jiayuan Zhu , Junde Wu , Cheng Ouyang , Konstantinos Kamnitsas , J. Alison Noble

Manual annotation of medical images is a labor-intensive and time-consuming process, posing a significant bottleneck in the development and deployment of robust medical imaging AI systems. This paper introduces a novel hands-free Human-AI…

Image and Video Processing · Electrical Eng. & Systems 2025-07-29 Yizhe Zhang

In critical decision support systems based on medical imaging, the reliability of AI-assisted decision-making is as relevant as predictive accuracy. Although deep learning models have demonstrated significant accuracy, they frequently…

Computer Vision and Pattern Recognition · Computer Science 2026-02-13 Hua Xu , Julián D. Arias-Londoño , Juan I. Godino-Llorente

Uncertainty estimation is important for interpreting the trustworthiness of machine learning models in many applications. This is especially critical in the data-driven active learning setting where the goal is to achieve a certain accuracy…

Computer Vision and Pattern Recognition · Computer Science 2020-07-14 Bo Li , Tommy Sonne Alstrøm

Deep learning-based medical image segmentation models often face performance degradation when deployed across various medical centers, largely due to the discrepancies in data distribution. Test Time Adaptation (TTA) methods, which adapt…

Computer Vision and Pattern Recognition · Computer Science 2024-05-15 Shishuai Hu , Zehui Liao , Zeyou Liu , Yong Xia

Accurately quantifying vitiligo extent in routine clinical photographs is crucial for longitudinal monitoring of treatment response. We propose a trustworthy, frequency-aware segmentation framework built on three synergistic pillars: (1) a…

Computer Vision and Pattern Recognition · Computer Science 2025-12-15 Wentao Jiang , Vamsi Varra , Caitlin Perez-Stable , Harrison Zhu , Meredith Apicella , Nicole Nyamongo

Accurate classification of computed tomography (CT) images is essential for diagnosis and treatment planning, but existing methods often struggle with the subtle and spatially diverse nature of pathological features. Current approaches…

Image and Video Processing · Electrical Eng. & Systems 2025-07-21 Shravan Venkatraman , Pavan Kumar S , Rakesh Raj Madavan , Chandrakala S

Trustworthy artificial intelligence (AI) is essential in healthcare, particularly for high-stakes tasks like medical image segmentation. Explainable AI and uncertainty quantification significantly enhance AI reliability by addressing key…

Although the U-Net architecture has been extensively used for segmentation of medical images, we address two of its shortcomings in this work. Firstly, the accuracy of vanilla U-Net degrades when the target regions for segmentation exhibit…

Manual segmentation is used as the gold-standard for evaluating neural networks on automated image segmentation tasks. Due to considerable heterogeneity in shapes, colours and textures, demarcating object boundaries is particularly…

Image and Video Processing · Electrical Eng. & Systems 2021-11-02 Michael Yeung , Guang Yang , Evis Sala , Carola-Bibiane Schönlieb , Leonardo Rundo

Annotation and labeling of images are some of the biggest challenges in applying deep learning to medical data. Current processes are time and cost-intensive and, therefore, a limiting factor for the wide adoption of the technology.…

Computer Vision and Pattern Recognition · Computer Science 2023-04-04 Manuel Zahn , Douglas P. Perrin

Placing a human in the loop may abate the risks of deploying AI systems in safety-critical settings (e.g., a clinician working with a medical AI system). However, mitigating risks arising from human error and uncertainty within such…

Predictions made by deep learning models are prone to data perturbations, adversarial attacks, and out-of-distribution inputs. To build a trusted AI system, it is therefore critical to accurately quantify the prediction uncertainties. While…

Machine Learning · Computer Science 2023-04-12 Hanjing Wang , Dhiraj Joshi , Shiqiang Wang , Qiang Ji