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Recent advances in generative models have inspired the field of recommender systems to explore generative approaches, but most existing research focuses on sequence generation, a paradigm ill-suited for click-through rate (CTR) prediction.…

Information Retrieval · Computer Science 2025-08-28 Moyu Zhang , Yun Chen , Yujun Jin , Jinxin Hu , Yu Zhang

Raman spectroscopy has attracted significant attention in various biochemical detection fields, especially in the rapid identification of pathogenic bacteria. The integration of this technology with deep learning to facilitate automated…

Computer Vision and Pattern Recognition · Computer Science 2024-12-12 Haiming Yao , Wei Luo , Ang Gao , Tao Zhou , Xue Wang

We present a parameter-efficient Diffusion Transformer (DiT) for generating 200bp cell-type-specific regulatory DNA sequences. By replacing the U-Net backbone of DNA-Diffusion with a transformer denoiser equipped with a 2D CNN input…

Machine Learning · Computer Science 2026-03-12 Jonathan Liu , Kia Ghods

While recommender systems have become an integral component of the Web experience, their heavy reliance on user data raises privacy and security concerns. Substituting user data with synthetic data can address these concerns, but accurately…

Information Retrieval · Computer Science 2024-06-21 Derek Lilienthal , Paul Mello , Magdalini Eirinaki , Stas Tiomkin

RNA inverse folding, designing sequences to form specific 3D structures, is critical for therapeutics, gene regulation, and synthetic biology. Current methods, focused on sequence recovery, struggle to address structural objectives like…

Machine Learning · Computer Science 2026-01-28 Qi Si , Xuyang Liu , Penglei Wang , Xin Guo , Yuan Qi , Yuan Cheng

Single-cell RNA sequencing (scRNA-seq) enables the study of cellular heterogeneity. Yet, clustering accuracy, and with it downstream analyses based on cell labels, remain challenging due to measurement noise and biological variability. In…

Machine Learning · Computer Science 2026-03-03 Dominik Meier , Shixing Yu , Sagnik Nandy , Promit Ghosal , Kyra Gan

In this paper, we address the problem of generative dataset distillation that utilizes generative models to synthesize images. The generator may produce any number of images under a preserved evaluation time. In this work, we leverage the…

Computer Vision and Pattern Recognition · Computer Science 2025-04-15 Junqiao Fan , Yunjiao Zhou , Min Chang Jordan Ren , Jianfei Yang

The challenge in fine-grained visual categorization lies in how to explore the subtle differences between different subclasses and achieve accurate discrimination. Previous research has relied on large-scale annotated data and pre-trained…

Computer Vision and Pattern Recognition · Computer Science 2024-05-16 Tianxu Wu , Shuo Ye , Shuhuang Chen , Qinmu Peng , Xinge You

Building Virtual Cells that can accurately simulate cellular responses to perturbations is a long-standing goal in systems biology. A fundamental challenge is that high-throughput single-cell sequencing is destructive: the same cell cannot…

Machine Learning · Computer Science 2026-02-24 Xinyu Yuan , Xixian Liu , Ya Shi Zhang , Zuobai Zhang , Hongyu Guo , Jian Tang

A central goal in systems biology and drug discovery is to predict the transcriptional response of cells to perturbations. This task is challenging due to the noisy and sparse nature of single-cell measurements, as well as the fact that…

Quantitative Methods · Quantitative Biology 2026-02-10 Chenglei Yu , Chuanrui Wang , Bangyan Liao , Tailin Wu

RNA sequencing (RNA-seq) is the conventional genome-scale approach used to capture the expression levels of all detectable genes in a biological sample. This is now regularly used for population-based studies designed to identify genetic…

Genomics · Quantitative Biology 2026-05-25 Christopher Thron , Farhad Jafari

Real-world image super-resolution (Real-ISR) must handle complex degradations and inherent reconstruction ambiguities. While generative models have improved perceptual quality, a key trade-off remains with computational cost. One-step…

Computer Vision and Pattern Recognition · Computer Science 2025-10-23 Yun Kai Zhuang

This paper introduces a methodology for generating synthetic annotated data to address data scarcity in semantic segmentation tasks within the precision agriculture domain. Utilizing Denoising Diffusion Probabilistic Models (DDPMs) and…

Computer Vision and Pattern Recognition · Computer Science 2024-11-07 Andrew Heschl , Mauricio Murillo , Keyhan Najafian , Farhad Maleki

Diffusion models based on permutation-equivariant networks can learn permutation-invariant distributions for graph data. However, in comparison to their non-invariant counterparts, we have found that these invariant models encounter greater…

Machine Learning · Computer Science 2024-06-21 Qi Yan , Zhengyang Liang , Yang Song , Renjie Liao , Lele Wang

Spatial transcriptomics (ST) is an emerging technology that enables researchers to investigate the molecular relationships underlying tissue morphology. However, acquiring ST data remains prohibitively expensive, and traditional fixed-grid…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Junchao Zhu , Ruining Deng , Junlin Guo , Tianyuan Yao , Chongyu Qu , Juming Xiong , Siqi Lu , Zhengyi Lu , Yanfan Zhu , Marilyn Lionts , Yuechen Yang , Yalin Zheng , Yu Wang , Shilin Zhao , Haichun Yang , Yuankai Huo

Denoising diffusion models (DDMs) have led to staggering performance leaps in image generation, editing and restoration. However, existing DDMs use very large datasets for training. Here, we introduce a framework for training a DDM on a…

Computer Vision and Pattern Recognition · Computer Science 2023-06-08 Vladimir Kulikov , Shahar Yadin , Matan Kleiner , Tomer Michaeli

Diffusion models for super-resolution (SR) produce high-quality visual results but require expensive computational costs. Despite the development of several methods to accelerate diffusion-based SR models, some (e.g., SinSR) fail to produce…

Computer Vision and Pattern Recognition · Computer Science 2026-02-05 Daniil Selikhanovych , David Li , Aleksei Leonov , Nikita Gushchin , Sergei Kushneriuk , Alexander Filippov , Evgeny Burnaev , Iaroslav Koshelev , Alexander Korotin

Modeling and reconstructing multidimensional physical dynamics from sparse and off-grid observations presents a fundamental challenge in scientific research. Recently, diffusion-based generative modeling shows promising potential for…

Machine Learning · Computer Science 2025-09-30 Panqi Chen , Yifan Sun , Lei Cheng , Yang Yang , Weichang Li , Yang Liu , Weiqing Liu , Jiang Bian , Shikai Fang

Hyperspectral images (HSI) have become popular for analysing remotely sensed images in multiple domain like agriculture, medical. However, existing models struggle with complex relationships and characteristics of spectral-spatial data due…

Computer Vision and Pattern Recognition · Computer Science 2023-12-21 Neetu Sigger , Tuan Thanh Nguyen , Gianluca Tozzi , Quoc-Tuan Vien , Sinh Van Nguyen

Synthetic data generation is an important application of machine learning in the field of medical imaging. While existing approaches have successfully applied fine-tuned diffusion models for synthesizing medical images, we explore potential…

Computer Vision and Pattern Recognition · Computer Science 2024-10-04 Lakshmi Nair