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Smoothed analysis is a framework for analyzing the complexity of an algorithm, acting as a bridge between average and worst-case behaviour. For example, Quicksort and the Simplex algorithm are widely used in practical applications, despite…

Machine Learning · Computer Science 2015-03-29 Bichen Shi , Michel Schellekens , Georgiana Ifrim

We present three algorithms for calculating rate constants and sampling transition paths for rare events in simulations with stochastic dynamics. The methods do not require a priori knowledge of the phase space density and are suitable for…

Soft Condensed Matter · Physics 2009-11-11 Rosalind J. Allen , Daan Frenkel , Pieter Rein ten Wolde

The goal of this paper is to develop provably efficient importance sampling Monte Carlo methods for the estimation of rare events within the class of linear stochastic partial differential equations (SPDEs). We find that if a spectral gap…

Probability · Mathematics 2017-05-05 Michael Salins , Konstantinos Spiliopoulos

The input of almost every machine learning algorithm targeting the properties of matter at the atomic scale involves a transformation of the list of Cartesian atomic coordinates into a more symmetric representation. Many of the most popular…

Machine Learning · Statistics 2022-01-11 Alexander Goscinski , Félix Musil , Sergey Pozdnyakov , Michele Ceriotti

We present an investigation into data selection methods for the efficient sampling of configuration space as applied to the development of inter-atomic potentials for scale bridging in molecular dynamics (MD) simulations. This investigation…

Computational Physics · Physics 2021-08-04 Jan Finkbeiner , Samuel Tovey , Christian Holm

This is a method for discrete event simulation specified by survival analysis. It presents a sequence of steps. First, hazard rates from survival analysis specify the rates of a set of counting processes. Second, those counting processes…

Computation · Statistics 2016-10-14 Andrew J. Dolgert

Randomly sampling points on surfaces is an essential operation in geometry processing. This sampling is computationally straightforward on explicit meshes, but it is much more difficult on other shape representations, such as widely-used…

Graphics · Computer Science 2025-06-16 Selena Ling , Abhishek Madan , Nicholas Sharp , Alec Jacobson

In environmental studies, realistic simulations are essential for understanding complex systems. Statistical emulation with Gaussian processes (GPs) in functional data models have become a standard tool for this purpose. Traditional…

Applications · Statistics 2024-09-26 R. Jacob Andros , Rajarshi Guhaniyogi , Devin Francom , Donatella Pasqualini

Strategic classification, i.e. classification under possible strategic manipulations of features, has received a lot of attention from both the machine learning and the game theory community. Most works focus on analysing properties of the…

Machine Learning · Computer Science 2022-03-28 Tosca Lechner , Ruth Urner

Brownian dynamics simulations are an increasingly popular tool for understanding spatially-distributed biochemical reaction systems. Recent improvements in our understanding of the cellular environment show that volume exclusion effects are…

Chemical Physics · Physics 2017-09-13 Stephen Smith , Ramon Grima

Rare event simulation and estimation for systems in equilibrium are among the most challenging topics in molecular dynamics. As was shown by Jarzynski and others, nonequilibrium forcing can theoretically be used to obtain equilibrium rare…

Optimization and Control · Mathematics 2015-06-11 Carsten Hartmann , Christof Schütte

We derive a novel efficient scheme to measure the rate constant of transitions between stable states separated by high free energy barriers in a complex environment within the framework of transition path sampling. The method is based on…

Statistical Mechanics · Physics 2009-11-07 Titus S. van Erp , Daniele Moroni , Peter G. Bolhuis

The determination of efficient collective variables is crucial to the success of many enhanced sampling methods. As inspired by previous discrimination approaches, we first collect a set of data from the different metastable basins. The…

Computational Physics · Physics 2026-03-03 Enrico Trizio , Michele Parrinello

A common problem that affects simulations of complex systems within the computational physics and chemistry communities is the so-called sampling problem or rare event problem where proper sampling of energy landscapes is impeded by the…

Computational Physics · Physics 2023-03-06 Benjamin Pampel , Simon Holbach , Lisa Hartung , Omar Valsson

Randomized smoothing is currently a state-of-the-art method to construct a certifiably robust classifier from neural networks against $\ell_2$-adversarial perturbations. Under the paradigm, the robustness of a classifier is aligned with the…

Machine Learning · Computer Science 2021-11-18 Jongheon Jeong , Sejun Park , Minkyu Kim , Heung-Chang Lee , Doguk Kim , Jinwoo Shin

Event-based cameras have recently drawn the attention of the Computer Vision community thanks to their advantages in terms of high temporal resolution, low power consumption and high dynamic range, compared to traditional frame-based…

Computer Vision and Pattern Recognition · Computer Science 2018-03-22 Amos Sironi , Manuele Brambilla , Nicolas Bourdis , Xavier Lagorce , Ryad Benosman

Molecular dynamics is a powerful tool for studying the thermodynamics and kinetics of complex molecular events. However, these simulations can rarely sample the required time scales in practice. Transition path sampling overcomes this…

Chemical Physics · Physics 2023-07-31 Gianmarco Lazzeri , Hendrik Jung , Peter G. Bolhuis , Roberto Covino

Simplicial Embeddings (SEM) are representations learned through self-supervised learning (SSL), wherein a representation is projected into $L$ simplices of $V$ dimensions each using a softmax operation. This procedure conditions the…

Activated processes from chemical reactions up to conformational transitions of large biomolecules are hampered by barriers which are overcome only by the input of some free energy of activation. Hence, the characteristic and…

Statistical Mechanics · Physics 2011-12-21 Jürgen Schlitter

Atypical, rare trajectories of dynamical systems are important: they are often the paths for chemical reactions, the haven of (relative) stability of planetary systems, the rogue waves that are detected in oil platforms, the structures that…

Statistical Mechanics · Physics 2012-04-12 Cristian Giardina , Jorge Kurchan , Vivien Lecomte , Julien Tailleur