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Iterative Proportional Fitting (IPF), combined with EM, is commonly used as an algorithm for likelihood maximization in undirected graphical models. In this paper, we present two iterative algorithms that generalize upon IPF. The first one…

Machine Learning · Computer Science 2013-01-07 Wim Wiegerinck , Tom Heskes

Subject-specific modeling is a powerful tool in cardiovascular research, providing insights beyond the reach of current clinical diagnostics. Limitations in available clinical data require the incorporation of uncertainty into models to…

Applications · Statistics 2025-07-16 Amirreza Kachabi , Sofia Altieri Correa , Naomi C. Chesler , Mitchel J. Colebank

Quantifying cardiovascular parameters like ejection fraction in zebrafish as a host of biological investigations has been extensively studied. Since current manual monitoring techniques are time-consuming and fallible, several image…

Image and Video Processing · Electrical Eng. & Systems 2026-03-03 Amir Mohammad Naderi , Jennifer G. Casey , Mao-Hsiang Huang , Rachelle Victorio , David Y. Chiang , Calum MacRae , Hung Cao , Vandana A. Gupta

In structural optimization, both parameters and shape are relevant for the model performance. Yet, conventional optimization techniques usually consider either parameters or the shape separately. This work addresses this problem by…

Optimization and Control · Mathematics 2025-03-18 Michael Wiesheu , Theodor Komann , Melina Merkel , Sebastian Schöps , Stefan Ulbrich , Idoia Cortes Garcia

To quantify how well theoretical predictions of structural ensembles agree with experimental measurements, we depend on the accuracy of forward models. These models are computational frameworks that generate observable quantities from…

Biological Physics · Physics 2025-11-04 Robert M. Raddi , Tim Marshall , Vincent A. Voelz

The combination of Finite Element Method (FEM) simulation and experimental photo-elasticity provides both qualitative and quantitative information about the stress field in a polymer composite and particularly along the fibre-matrix…

Materials Science · Physics 2007-05-23 H. Matthias Deuschle , Falk K. Wittel , Henry Gerhard , Gerhard Busse , Bernd-H. Kroeplin

Conventional radio frequency (RF) passive components modeling based on machine learning requires extensive electromagnetic (EM) simulations to cover geometric and frequency design spaces, creating computational bottlenecks. In this paper,…

Machine Learning · Computer Science 2025-11-20 Huifan Zhang , Pingqiang Zhou

Many problems within personalized medicine and digital health rely on the analysis of continuous-time functional biomarkers and other complex data structures emerging from high-resolution patient monitoring. In this context, this work…

Machine Learning · Statistics 2025-01-14 Marcos Matabuena

This paper describes a novel homogenization methodology for analyzing the failure of elastoplastic composite materials based on elastic and eigen influence tensors-driven transformation field analysis ($\mathtt{E}^2$-TFA). The proposed…

Computational Engineering, Finance, and Science · Computer Science 2025-09-26 Harpreet Singh

Electroanatomical mapping is a technique used in cardiology to create a detailed 3D map of the electrical activity in the heart. It is useful for diagnosis, treatment planning and real time guidance in cardiac ablation procedures to treat…

Image and Video Processing · Electrical Eng. & Systems 2023-11-29 Sunil Mathew , Jasbir Sra , Daniel B. Rowe

Recent years have seen growing interest in the diagnosis of Coronary Artery Disease (CAD) with machine learning methods to reduce the cost and health implications of conventional diagnosis. This paper introduces a CAD diagnosis method with…

Machine Learning · Computer Science 2021-09-24 Ali Yavari , Amir Rajabzadeh , Fardin Abdali-Mohammadi

The objective of this study is to establish a gradient-free topology optimization framework that facilitates more global solution searches to avoid entrapping in undesirable local optima, especially in problems with strong non-linearity.…

Optimization and Control · Mathematics 2025-03-07 Hiroki Kawabe , Kentaro Yaji , Yuichiro Aoki

Enhancing seismic fragility and risk assessment of nuclear power plants relies on accurate prediction of reactor building responses to seismic hazards, which can be further improved through dynamic analysis of high-fidelity finite element…

Applications · Statistics 2026-04-27 Taro Yaoyama , Sangwon Lee , Minoru Matsubara , Kenzo Kodera , Takeshi Ugata , Tatsuya Itoi

We present a new explicit local space-time adaptive framework to decrease the time required for monodomain simulations for cardiac electrophysiology. Based on the localized structure of the steep activation wavefront in solutions to…

Numerical Analysis · Mathematics 2025-02-03 Dennis Ogiermann , Daniel Balzani , Luigi E. Perotti

Accurate segmentation of myocardial lesions from multi-sequence cardiac magnetic resonance imaging is essential for cardiac disease diagnosis and treatment planning. However, achieving optimal feature correspondence is challenging due to…

Image and Video Processing · Electrical Eng. & Systems 2025-07-17 Yifan Gao , Shaohao Rui , Haoyang Su , Jinyi Xiang , Lianming Wu , Xiaosong Wang

Cardiac action potential models allow examination of a variety of cardiac dynamics, including how behavior may change under specific interventions. To study a specific scenario, including patient-specific cases, model parameter sets must be…

Computational Engineering, Finance, and Science · Computer Science 2025-04-21 Darby I. Cairns , Maxfield R. Comstock , Flavio H. Fenton , Elizabeth M. Cherry

This article presents new immersed finite element (IFE) methods for solving the popular second order elliptic interface problems on structured Cartesian meshes even if the involved interfaces have nontrivial geometries. These IFE methods…

Numerical Analysis · Mathematics 2018-10-29 Tao Lin , Yanping Lin , Xu Zhang

In the field of cardiac electrophysiology (EP), effectively reducing noise in intra-cardiac signals is crucial for the accurate diagnosis and treatment of arrhythmias and cardiomyopathies. However, traditional noise reduction techniques…

Studies of the degrees of freedom or "synergies" in musculoskeletal systems rely critically on algorithms to estimate the "dimension" of kinematic or neural data. Linear algorithms such as principal component analysis (PCA) are used almost…

Quantitative Methods · Quantitative Biology 2007-05-23 Robert H. Clewley , John M. Guckenheimer , Francisco J. Valero-Cuevas

Understanding the biomechanics of the heart in health and disease plays an important role in the diagnosis and treatment of heart failure. The use of computational biomechanical models for therapy assessment is paving the way for…

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