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Use of historical data and real-world evidence holds great potential to improve the efficiency of clinical trials. One major challenge is how to effectively borrow information from historical data while maintaining a reasonable type I…

Methodology · Statistics 2020-12-15 Liyun Jiang , Lei Nie , Ying Yuan

For decades, atomistic modeling has played a crucial role in predicting the behavior of materials in numerous fields ranging from nanotechnology to drug discovery. The most accurate methods in this domain are rooted in first-principles…

Machine Learning · Computer Science 2022-10-18 Zeren Shui , Daniel S. Karls , Mingjian Wen , Ilia A. Nikiforov , Ellad B. Tadmor , George Karypis

We consider the problem of multiple hypothesis testing with generic side information: for each hypothesis $H_i$ we observe both a p-value $p_i$ and some predictor $x_i$ encoding contextual information about the hypothesis. For large-scale…

Methodology · Statistics 2018-07-26 Lihua Lei , William Fithian

We develop a Bayesian nonparametric approach to a general family of latent class problems in which individuals can belong simultaneously to multiple classes and where each class can be exhibited multiple times by an individual. We introduce…

Methodology · Statistics 2013-06-11 Tamara Broderick , Lester Mackey , John Paisley , Michael I. Jordan

One of the main approaches used to construct prior distributions for objective Bayes methods is the concept of random imaginary observations. Under this setup, the expected-posterior prior (EPP) offers several advantages, among which it has…

Methodology · Statistics 2020-10-09 Dimitris Fouskakis , Ioannis Ntzoufras

Dataset bias, i.e., the over-reliance on dataset-specific literal heuristics, is getting increasing attention for its detrimental effect on the generalization ability of NLU models. Existing works focus on eliminating dataset bias by…

Computation and Language · Computer Science 2023-05-05 Songyang Gao , Shihan Dou , Junjie Shan , Qi Zhang , Xuanjing Huang

Primordial power spectra with low power at long wavelengths can alleviate lensing anomaly. However the extent to which data favours such a primordial spectra is not clear. In this work, we investigate power suppression and related…

Cosmology and Nongalactic Astrophysics · Physics 2026-02-03 Roshna K , V. Sreenath

In recent years, the integration of Machine Learning (ML) models with Operation Research (OR) tools has gained popularity across diverse applications, including cancer treatment, algorithmic configuration, and chemical process optimization.…

Machine Learning · Computer Science 2023-07-17 Matteo Cacciola , Antonio Frangioni , Andrea Lodi

It is highly desirable to borrow information from external data to augment a control arm in a randomized clinical trial, especially in settings where the sample size for the control arm is limited. However, a main challenge in borrowing…

Methodology · Statistics 2023-11-01 Dehua Bi , Tianjian Zhou , Wei Zhong , Yuan Ji

In this work, we generalize the problem of learning through interaction in a POMDP by accounting for eventual additional information available at training time. First, we introduce the informed POMDP, a new learning paradigm offering a…

Machine Learning · Computer Science 2025-06-09 Gaspard Lambrechts , Adrien Bolland , Damien Ernst

In the context of the expected-posterior prior (EPP) approach to Bayesian variable selection in linear models, we combine ideas from power-prior and unit-information-prior methodologies to simultaneously produce a minimally-informative…

Computation · Statistics 2015-04-27 Dimitris Fouskakis , Ioannis Ntzoufras , David Draper

Unlike machines, humans learn through rapid, abstract model-building. The role of a teacher is not simply to hammer home right or wrong answers, but rather to provide intuitive comments, comparisons, and explanations to a pupil. This is…

Machine Learning · Computer Science 2018-05-30 John Lambert , Ozan Sener , Silvio Savarese

The normal-normal hierarchical model (NNHM) constitutes a simple and widely used framework for meta-analysis. In the common case of only few studies contributing to the meta-analysis, standard approaches to inference tend to perform poorly,…

While learning to align Large Language Models (LLMs) with human preferences has shown remarkable success, aligning these models to meet the diverse user preferences presents further challenges in preserving previous knowledge. This paper…

Artificial Intelligence · Computer Science 2024-10-01 Gihun Lee , Minchan Jeong , Yujin Kim , Hojung Jung , Jaehoon Oh , Sangmook Kim , Se-Young Yun

As language models (LMs) become more capable, it is increasingly important to align them with human preferences. However, the dominant paradigm for training Preference Models (PMs) for that purpose suffers from fundamental limitations, such…

Computation and Language · Computer Science 2024-03-18 Dongyoung Go , Tomasz Korbak , Germán Kruszewski , Jos Rozen , Marc Dymetman

Feed-forward neural networks can be understood as a combination of an intermediate representation and a linear hypothesis. While most previous works aim to diversify the representations, we explore the complementary direction by performing…

Machine Learning · Computer Science 2019-10-24 Han Zhao , Yao-Hung Hubert Tsai , Ruslan Salakhutdinov , Geoffrey J. Gordon

Recent Vision-Language Pretrained (VLP) models have become the backbone for many downstream tasks, but they are utilized as frozen model without learning. Prompt learning is a method to improve the pre-trained VLP model by adding a…

Computation and Language · Computer Science 2024-01-17 Youngjae Cho , HeeSun Bae , Seungjae Shin , Yeo Dong Youn , Weonyoung Joo , Il-Chul Moon

Research in oncology has changed the focus from histological properties of tumors in a specific organ to a specific genomic aberration potentially shared by multiple cancer types. This motivates the basket trial, which assesses the efficacy…

Applications · Statistics 2020-02-11 Jin Jin , Marie-Karelle Riviere , Xiaodong Luo , Yingwen Dong

Online news platforms often use personalized news recommendation methods to help users discover articles that align with their interests. These methods typically predict a matching score between a user and a candidate article to reflect the…

Information Retrieval · Computer Science 2023-04-18 Xinyi Li , Yongfeng Zhang , Edward C. Malthouse

We propose a bias-aware methodology to engage with power relations in natural language processing (NLP) research. NLP research rarely engages with bias in social contexts, limiting its ability to mitigate bias. While researchers have…

Computation and Language · Computer Science 2020-11-12 Lucy Havens , Melissa Terras , Benjamin Bach , Beatrice Alex
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