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Understanding the chemical structure from a graphical representation of a molecule is a challenging image caption task that would greatly benefit molecule-centric scientific discovery. Variations in molecular images and caption subtasks…

Computer Vision and Pattern Recognition · Computer Science 2025-05-23 Siqi Fan , Yuguang Xie , Bowen Cai , Ailin Xie , Gaochao Liu , Mu Qiao , Jie Xing , Zaiqing Nie

Optical chemical structure recognition (OCSR) systems aim to extract the molecular structure information, usually in the form of molecular graph or SMILES, from images of chemical molecules. While many tools have been developed for this…

Computer Vision and Pattern Recognition · Computer Science 2024-07-29 Ching Ting Leung , Yufan Chen , Hanyu Gao

Optical Chemical Structure Recognition (OCSR) plays a pivotal role in modern chemical informatics, enabling the automated conversion of chemical structure images from scientific literature, patents, and educational materials into…

Computer Vision and Pattern Recognition · Computer Science 2025-11-24 Wenrui Zhang , Xinggang Wang , Bin Feng , Wenyu Liu

In drug discovery, knowledge of the graph structure of chemical compounds is essential. Many thousands of scientific articles in chemistry and pharmaceutical sciences have investigated chemical compounds, but in cases the details of the…

Machine Learning · Statistics 2020-09-16 Martijn Oldenhof , Adam Arany , Yves Moreau , Jaak Simm

Optical chemical structure recognition (OCSR) translates molecular images into machine-readable representations like SMILES strings or molecular graphs, but remains challenging in real-world documents due to inexhaustible variations in…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Zhuoqi Lyu , Qing Ke

Automatic extraction of chemical structures from scientific literature plays a crucial role in accelerating research across fields ranging from drug discovery to materials science. Patent documents, in particular, contain molecular…

Computer Vision and Pattern Recognition · Computer Science 2025-10-09 Lucas Morin , Gerhard Ingmar Meijer , Valéry Weber , Luc Van Gool , Peter W. J. Staar

Molecular structures are always depicted as 2D printed form in scientific documents like journal papers and patents. However, these 2D depictions are not machine-readable. Due to a backlog of decades and an increasing amount of these…

Computer Vision and Pattern Recognition · Computer Science 2022-05-24 Youjun Xu , Jinchuan Xiao , Chia-Han Chou , Jianhang Zhang , Jintao Zhu , Qiwan Hu , Hemin Li , Ningsheng Han , Bingyu Liu , Shuaipeng Zhang , Jinyu Han , Zhen Zhang , Shuhao Zhang , Weilin Zhang , Luhua Lai , Jianfeng Pei

The automatic analysis of chemical literature has immense potential to accelerate the discovery of new materials and drugs. Much of the critical information in patent documents and scientific articles is contained in figures, depicting the…

Computer Vision and Pattern Recognition · Computer Science 2024-08-29 Lucas Morin , Martin Danelljan , Maria Isabel Agea , Ahmed Nassar , Valery Weber , Ingmar Meijer , Peter Staar , Fisher Yu

Optical Chemical Structure Recognition (OCSR) is critical for converting 2D molecular diagrams from printed literature into machine-readable formats. While Vision-Language Models have shown promise in end-to-end OCR tasks, their direct…

Computer Vision and Pattern Recognition · Computer Science 2026-04-22 Haocheng Tang , Xingyu Dang , Junmei Wang

In recent years, machine learning (ML) has gained significant popularity in the field of chemical informatics and electronic structure theory. These techniques often require researchers to engineer abstract "features" that encode chemical…

Human-Computer Interaction · Computer Science 2022-07-11 Xiangyun Lei , Fred Hohman , Duen Horng Chau , Andrew J. Medford

Molecular structure recognition is the task of translating a molecular image into its graph structure. Significant variation in drawing styles and conventions exhibited in chemical literature poses a significant challenge for automating…

Computer Vision and Pattern Recognition · Computer Science 2023-03-22 Yujie Qian , Jiang Guo , Zhengkai Tu , Zhening Li , Connor W. Coley , Regina Barzilay

The crucial field of Optical Chemical Structure Recognition (OCSR) aims to transform chemical structure photographs into machine-readable formats so that chemical databases may be efficiently stored and queried. Although a number of OCSR…

Machine Learning · Computer Science 2025-02-25 Zishuo Lin , Jiajie Wang , Zhe Yan , Peiyong Ma

In the field of chemical structure recognition, the task of converting molecular images into machine-readable data formats such as SMILES string stands as a significant challenge, primarily due to the varied drawing styles and conventions…

Computer Vision and Pattern Recognition · Computer Science 2025-03-12 Yufan Chen , Ching Ting Leung , Yong Huang , Jianwei Sun , Hao Chen , Hanyu Gao

For several decades, chemical knowledge has been published in written text, and there have been many attempts to make it accessible, for example, by transforming such natural language text to a structured format. Although the discovered…

Computer Vision and Pattern Recognition · Computer Science 2022-02-22 Sanghyun Yoo , Ohyun Kwon , Hoshik Lee

Optical Chemical Structure Recognition (OCSR) is essential for converting molecular images into machine-readable formats. While recent vision-language models (VLMs) have shown promise, their image-captioning approach often struggles with…

Artificial Intelligence · Computer Science 2026-01-14 Jingchao Wang , Yifan He , Haote Yang , Jiang Wu , Lingli Ge , Xingjian Wei , Yinfan Wang , Linye Li , Huijie Ao , Chengjin Liu , Bin Wang , Lijun Wu , Conghui He

The detailed analysis of molecular structures and properties holds great potential for drug development discovery through machine learning. Developing an emergent property in the model to understand molecules would broaden the horizons for…

SMILES is a linear representation of chemical structures which encodes the connection table, and the stereochemistry of a molecule as a line of text with a grammar structure denoting atoms, bonds, rings and chains, and this information can…

Machine Learning · Computer Science 2018-12-03 Arindam Paul , Dipendra Jha , Reda Al-Bahrani , Wei-keng Liao , Alok Choudhary , Ankit Agrawal

Scanning tunnelling microscopy (STM) is a powerful technique for imaging surfaces with atomic resolution, providing insight into physical and chemical processes at the level of single atoms and molecules. A regular task of STM image…

In drug-discovery-related tasks such as virtual screening, machine learning is emerging as a promising way to predict molecular properties. Conventionally, molecular fingerprints (numerical representations of molecules) are calculated…

Machine Learning · Computer Science 2019-11-13 Shion Honda , Shoi Shi , Hiroki R. Ueda

In recent decades, chemistry publications and patents have increased rapidly. A significant portion of key information is embedded in molecular structure figures, complicating large-scale literature searches and limiting the application of…

Computer Vision and Pattern Recognition · Computer Science 2025-09-22 Xi Fang , Jiankun Wang , Xiaochen Cai , Shangqian Chen , Shuwen Yang , Haoyi Tao , Nan Wang , Lin Yao , Linfeng Zhang , Guolin Ke
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