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Social media can reveal patient experiences with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) that extend beyond clinical trial data. We analyzed 410,198 Reddit posts (May 2019-June 2025) mentioning semaglutide or tirzepatide. A…

Social and Information Networks · Computer Science 2026-03-16 Neil K. R. Sehgal , Jena Shaw Tronieri , Lyle Ungar , Sharath Chandra Guntuku

Adverse drug reactions / events (ADR/ADE) have a major impact on patient health and health care costs. Detecting ADR's as early as possible and sharing them with regulators, pharma companies, and healthcare providers can prevent morbidity…

Computation and Language · Computer Science 2022-01-07 Hasham Ul Haq , Veysel Kocaman , David Talby

Adverse Events (AE) are harmful events resulting from the use of medical products. Although social media may be crucial for early AE detection, the sheer scale of this data makes it logistically intractable to analyze using human agents,…

Computation and Language · Computer Science 2021-09-14 Shivam Raval , Hooman Sedghamiz , Enrico Santus , Tuka Alhanai , Mohammad Ghassemi , Emmanuele Chersoni

Adverse Drug Reaction (ADR) is a significant public health concern world-wide. Numerous graph-based methods have been applied to biomedical graphs for predicting ADRs in pre-marketing phases. ADR detection in post-market surveillance is no…

Machine Learning · Computer Science 2020-04-02 Heeyoung Kwak , Minwoo Lee , Seunghyun Yoon , Jooyoung Chang , Sangmin Park , Kyomin Jung

Adverse drug reactions (ADRs) are unwanted or harmful effects experienced after the administration of a certain drug or a combination of drugs, presenting a challenge for drug development and drug administration. In this paper, we present a…

Computation and Language · Computer Science 2019-05-29 Maksim Belousov , Nikola Milosevic , William Dixon , Goran Nenadic

Adverse drug reactions (ADRs) are big concern for public health. ADRs are one of most common causes to withdraw some drugs from markets. Now two major methods for detecting ADRs are spontaneous reporting system (SRS), and prescription event…

Computational Engineering, Finance, and Science · Computer Science 2013-09-02 Yihui Liu , Uwe Aickelin

Adverse drug reactions considerably impact patient outcomes and healthcare costs in cancer therapy. Using artificial intelligence to predict adverse drug reactions in real time could revolutionize oncology treatment. This study aims to…

Quantitative Methods · Quantitative Biology 2025-05-21 Fatma Zahra Abdeldjouad , Menaouer Brahami , Mohammed Sabri

With the advancements in Artificial intelligence (AI) and the accumulation of healthrelated big data, it has become increasingly feasible and commonplace to leverage machine learning technologies to analyze clinical and omics metadata to…

Genomics · Quantitative Biology 2022-04-14 Attayeb Mohsen , Lokesh P. Tripathi , Kenji Mizuguchi

Adverse drug reaction (ADR) is widely concerned for public health issue. In this study we propose an original approach to detect the ADRs using feature matrix and feature selection. The experiments are carried out on the drug Simvastatin.…

Computational Engineering, Finance, and Science · Computer Science 2013-07-05 Yihui Liu , Uwe Aickelin

Automatic monitoring of adverse drug events (ADEs) or reactions (ADRs) is currently receiving significant attention from the biomedical community. In recent years, user-generated data on social media has become a valuable resource for this…

Computation and Language · Computer Science 2023-11-21 Ilseyar Alimova , Elena Tutubalina

The use of multiple drugs accounts for almost 30% of all hospital admission and is the 5th leading cause of death in America. Since over 30% of all adverse drug events (ADEs) are thought to be caused by drug-drug interactions (DDI), better…

Quantitative Methods · Quantitative Biology 2020-09-02 Ricky Wang

In the last decade, an increasing number of users have started reporting Adverse Drug Events (ADE) on social media platforms, blogs, and health forums. Given the large volume of reports, pharmacovigilance has focused on ways to use Natural…

Computation and Language · Computer Science 2022-09-08 Simone Scaboro , Beatrice Portelli , Emmanuele Chersoni , Enrico Santus , Giuseppe Serra

Adverse drug reaction (ADR) is widely concerned for public health issue. ADRs are one of most common causes to withdraw some drugs from market. Prescription event monitoring (PEM) is an important approach to detect the adverse drug…

Computational Engineering, Finance, and Science · Computer Science 2013-07-08 Yihui Liu , Uwe Aickelin

Adverse drug reactions (ADR) are widely concerning for public health issue. In this study we propose an original approach to detect ADRs using a feature matrix and feature selection. The experiments are carried out on the drug Simvastatin.…

Computational Engineering, Finance, and Science · Computer Science 2014-09-04 Yihui Liu , Uwe Aickelin

Adverse Drug Reactions (ADRs) are a leading cause of morbidity and mortality. Existing prediction methods rely mainly on chemical similarity, machine learning on structured databases, or isolated target profiles, but often fail to integrate…

Biomolecules · Quantitative Biology 2026-03-03 David Jackson , Michael Gertz , Jürgen Hesser

The automation of adverse drug reaction (ADR) detection in social media would revolutionize the practice of pharmacovigilance, supporting drug regulators, the pharmaceutical industry and the general public in ensuring the safety of the…

Computation and Language · Computer Science 2020-05-15 Amy Breden , Lee Moore

Opioid addiction is a severe public health threat in the U.S, causing massive deaths and many social problems. Accurate relapse prediction is of practical importance for recovering patients since relapse prediction promotes timely relapse…

Social and Information Networks · Computer Science 2018-11-30 Zhou Yang , Long Nguyen , Fang Jin

Meta-analysis is a powerful tool for assessing drug safety by combining treatment-related toxicological findings across multiple studies, as clinical trials are typically underpowered for detecting adverse drug effects. However, incomplete…

Spontaneous reporting system databases are key resources for post-marketing surveillance, providing real-world evidence (RWE) on the adverse events (AEs) of regulated drugs or other medical products. Various statistical methods have been…

Methodology · Statistics 2026-03-24 Xin-Wei Huang , Saptarshi Chakraborty

Social media has grown to be a crucial information source for pharmacovigilance studies where an increasing number of people post adverse reactions to medical drugs that are previously unreported. Aiming to effectively monitor various…

Machine Learning · Computer Science 2018-02-19 Shaika Chowdhury , Chenwei Zhang , Philip S. Yu
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