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Objective: To pre-train fair and unbiased patient representations from Electronic Health Records (EHRs) using a novel weighted loss function that reduces bias and improves fairness in deep representation learning models. Methods: We defined…

Machine Learning · Computer Science 2023-06-07 Sonish Sivarajkumar , Yufei Huang , Yanshan Wang

Machine learning holds great promise for advancing the field of medicine, with electronic health records (EHRs) serving as a primary data source. However, EHRs are often sparse and contain missing data due to various challenges and…

Machine Learning · Computer Science 2026-02-25 Jun Han , Josue Nassar , Sanjit Singh Batra , Aldo Cordova-Palomera , Vijay Nori , Robert E. Tillman

Electronic health records (EHR) contain narrative notes that provide extensive details on the medical condition and management of patients. Natural language processing (NLP) of clinical notes can use observed frequencies of clinical terms…

Computation and Language · Computer Science 2023-07-04 Bryan Cai , Sihang Zeng , Yucong Lin , Zheng Yuan , Doudou Zhou , Lu Tian

Electronic health record (EHR) data are increasingly used to support real-world evidence (RWE) studies. Yet its ability to generate reliable RWE is limited by the lack of readily available precise information on the timing of clinical…

The widespread digitization of patient data via electronic health records (EHRs) has created an unprecedented opportunity to use machine learning algorithms to better predict disease risk at the patient level. Although predictive models…

Recent advancements in semi-supervised learning have focused on a more realistic yet challenging task: addressing imbalances in labeled data while the class distribution of unlabeled data remains both unknown and potentially mismatched.…

Machine Learning · Computer Science 2024-07-31 Chaoqun Du , Yizeng Han , Gao Huang

One fundamental statistical question for research areas such as precision medicine and health disparity is about discovering effect modification of treatment or exposure by observed covariates. We propose a semiparametric framework for…

Methodology · Statistics 2020-08-04 Muxuan Liang , Menggang Yu

Analysis of longitudinal Electronic Health Record (EHR) data is an important goal for precision medicine. Difficulty in applying Machine Learning (ML) methods, either predictive or unsupervised, stems in part from the heterogeneity and…

Quantitative Methods · Quantitative Biology 2022-04-18 Alan D. Kaplan , Uttara Tipnis , Jean C. Beckham , Nathan A. Kimbrel , David W. Oslin , Benjamin H. McMahon

Covariate balance is a conventional key diagnostic for methods used estimating causal effects from observational studies. Recently, there is an emerging interest in directly incorporating covariate balance in the estimation. We study a…

Methodology · Statistics 2017-02-14 Qingyuan Zhao , Daniel Percival

The recent adoption of Electronic Health Records (EHRs) by health care providers has introduced an important source of data that provides detailed and highly specific insights into patient phenotypes over large cohorts. These datasets, in…

Semi-supervised learning methods are motivated by the availability of large datasets with unlabeled features in addition to labeled data. Unlabeled data is, however, not guaranteed to improve classification performance and has in fact been…

Machine Learning · Statistics 2019-10-25 Xiuming Liu , Dave Zachariah , Johan Wågberg , Thomas B. Schön

Prognostication for lung cancer, a leading cause of mortality, remains a complex task, as it needs to quantify the associations of risk factors and health events spanning a patient's entire life. One challenge is that an individual's…

Machine Learning · Statistics 2025-08-28 Stephen Salerno , Yi Li

Electronic Health Records (EHR) contain valuable clinical information for predicting patient outcomes and guiding healthcare decisions. However, effectively modeling Electronic Health Records (EHRs) requires addressing data heterogeneity…

Machine Learning · Computer Science 2025-07-22 Junhan Yu , Zhunyi Feng , Junwei Lu , Tianxi Cai , Doudou Zhou

Recent advancements in semi-supervised deep learning have introduced effective strategies for leveraging both labeled and unlabeled data to improve classification performance. This work proposes a semi-supervised framework that utilizes a…

Machine Learning · Computer Science 2025-05-21 Aydin Abedinia , Shima Tabakhi , Vahid Seydi

Deep learning has achieved remarkable success in graph-related tasks, yet this accomplishment heavily relies on large-scale high-quality annotated datasets. However, acquiring such datasets can be cost-prohibitive, leading to the practical…

Machine Learning · Computer Science 2024-03-11 Ling-Hao Chen , Yuanshuo Zhang , Taohua Huang , Liangcai Su , Zeyi Lin , Xi Xiao , Xiaobo Xia , Tongliang Liu

Large-scale biobanks are being collected around the world in efforts to better understand human health and risk factors for disease. They often survey hundreds of thousands of individuals, combining questionnaires with clinical, genetic,…

Quantitative Methods · Quantitative Biology 2019-03-19 Qifan Yang , Gennady V. Roshchupkin , Wiro J. Niessen , Sarah E. Medland , Alyssa H. Zhu , Paul M. Thompson , Neda Jahanshad

Automatic speech recognition (ASR) outcomes serve as input for downstream tasks, substantially impacting the satisfaction level of end-users. Hence, the diagnosis and enhancement of the vulnerabilities present in the ASR model bear…

Computation and Language · Computer Science 2024-01-29 Seonmin Koo , Chanjun Park , Jinsung Kim , Jaehyung Seo , Sugyeong Eo , Hyeonseok Moon , Heuiseok Lim

Disease risk prediction has attracted increasing attention in the field of modern healthcare, especially with the latest advances in artificial intelligence (AI). Electronic health records (EHRs), which contain heterogeneous patient…

Artificial Intelligence · Computer Science 2022-01-19 Shuai Niu , Qing Yin , Yunya Song , Yike Guo , Xian Yang

Feature selection is among the most important components because it not only helps enhance the classification accuracy, but also or even more important provides potential biomarker discovery. However, traditional multivariate methods is…

Computer Vision and Pattern Recognition · Computer Science 2016-05-26 Yilun Wang , Zhiqiang Li , Yifeng Wang , Xiaona Wang , Junjie Zheng , Xujuan Duan , Huafu Chen

Systems that can automatically analyze EEG signals can aid neurologists by reducing heavy workload and delays. However, such systems need to be first trained using a labeled dataset. While large corpuses of EEG data exist, a fraction of…

Machine Learning · Computer Science 2019-11-11 Subhrajit Roy , Kiran Kate , Martin Hirzel