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This paper investigates the challenges of developing large language models (LLMs) proficient in both multilingual understanding and medical knowledge. We demonstrate that simply translating medical data does not guarantee strong performance…

Computation and Language · Computer Science 2025-01-20 Nada Saadi , Tathagata Raha , Clément Christophe , Marco AF Pimentel , Ronnie Rajan , Praveen K Kanithi

Adapting general large language models (LLMs) to specialized domains presents great challenges due to varied data distributions. This adaptation typically requires continual pre-training on massive domain-specific corpora to facilitate…

Computation and Language · Computer Science 2024-07-16 Jinhao Jiang , Junyi Li , Wayne Xin Zhao , Yang Song , Tao Zhang , Ji-Rong Wen

Large Language Models (LLMs) have shown promising results on machine translation for high resource language pairs and domains. However, in specialised domains (e.g. medical) LLMs have shown lower performance compared to standard neural…

Computation and Language · Computer Science 2025-07-31 Miguel Rios

Sentence embeddings are an important component of many natural language processing (NLP) systems. Like word embeddings, sentence embeddings are typically learned on large text corpora and then transferred to various downstream tasks, such…

Computation and Language · Computer Science 2021-05-28 John Giorgi , Osvald Nitski , Bo Wang , Gary Bader

The introduction of Large Language Models (LLMs), and the vast volume of publicly available medical data, amplified the application of NLP to the medical domain. However, LLMs are pretrained on data that are not explicitly relevant to the…

Computation and Language · Computer Science 2023-12-12 Chris Solomou

Large Language Models (LLMs) pre-trained on massive corpora have exhibited remarkable performance on various NLP tasks. However, applying these models to specific domains still poses significant challenges, such as lack of domain knowledge,…

Computation and Language · Computer Science 2023-12-27 Shirong Ma , Shen Huang , Shulin Huang , Xiaobin Wang , Yangning Li , Hai-Tao Zheng , Pengjun Xie , Fei Huang , Yong Jiang

Large Language Models (LLMs) have demonstrated surprising performance across various natural language processing tasks. Recently, medical LLMs enhanced with domain-specific knowledge have exhibited excellent capabilities in medical…

Computation and Language · Computer Science 2024-09-24 Jinqiang Wang , Huansheng Ning , Yi Peng , Qikai Wei , Daniel Tesfai , Wenwei Mao , Tao Zhu , Runhe Huang

Fine-tuning pre-trained language models (PLMs) has demonstrated its effectiveness on various downstream NLP tasks recently. However, in many low-resource scenarios, the conventional fine-tuning strategies cannot sufficiently capture the…

Computation and Language · Computer Science 2021-11-15 Yusheng Su , Xu Han , Yankai Lin , Zhengyan Zhang , Zhiyuan Liu , Peng Li , Jie Zhou , Maosong Sun

Recently, Large Language Models (LLM) have demonstrated impressive capability to solve a wide range of tasks. However, despite their success across various tasks, no prior work has investigated their capability in the biomedical domain yet.…

Computation and Language · Computer Science 2024-02-21 Israt Jahan , Md Tahmid Rahman Laskar , Chun Peng , Jimmy Huang

Text embeddings have become an essential part of a variety of language applications. However, methods for interpreting, exploring and reversing embedding spaces are limited, reducing transparency and precluding potentially valuable…

Computation and Language · Computer Science 2026-01-27 Brian Ondov , Chia-Hsuan Chang , Yujia Zhou , Mauro Giuffrè , Hua Xu

Pre-training has shown success in different areas of machine learning, such as Computer Vision, Natural Language Processing (NLP), and medical imaging. However, it has not been fully explored for clinical data analysis. An immense amount of…

Machine Learning · Computer Science 2023-07-18 Chantal Pellegrini , Nassir Navab , Anees Kazi

We explore efficient strategies to fine-tune decoder-only Large Language Models (LLMs) for downstream text classification under resource constraints. Two approaches are investigated: (1) attaching a classification head to a pretrained…

Computation and Language · Computer Science 2026-05-26 Amirhossein Yousefiramandi , Ciaran Cooney

Fine-tuning of Large Language Models (LLMs) for downstream tasks, performed on domain-specific data has shown significant promise. However, commercial use of such LLMs is limited by the high computational cost required for their deployment…

Computation and Language · Computer Science 2025-03-06 Boris Nazarov , Darya Frolova , Yackov Lubarsky , Alexei Gaissinski , Pavel Kisilev

Large language models (LLMs) rely on pretraining on massive and heterogeneous corpora, where training data composition has a decisive impact on training efficiency and downstream generalization under realistic compute and data budget…

Computation and Language · Computer Science 2026-04-21 Zhuo Chen , Yuxuan Miao , Supryadi , Deyi Xiong

Recent advances in NLP are brought by a range of large-scale pretrained language models (PLMs). These PLMs have brought significant performance gains for a range of NLP tasks, circumventing the need to customize complex designs for specific…

Computation and Language · Computer Science 2022-11-08 Xu Guo , Han Yu

Several recent works seek to develop foundation models specifically for medical applications, adapting general-purpose large language models (LLMs) and vision-language models (VLMs) via continued pretraining on publicly available biomedical…

Computation and Language · Computer Science 2024-11-21 Daniel P. Jeong , Saurabh Garg , Zachary C. Lipton , Michael Oberst

The advent of transformer-based architectures and large language models (LLMs) have significantly advanced the performance of natural language processing (NLP) models. Since these LLMs are trained on huge corpuses of data from the web and…

Computation and Language · Computer Science 2024-08-29 Arkadeep Baksi , Rahul Singh , Tarun Joshi

Masked Language Modeling (MLM) pre-training is one of the primary ways to initialize Neural Information Retrieval (IR) models prior to retrieval fine-tuning. However, studies show that MLM pre-trained models have limited readiness and…

Information Retrieval · Computer Science 2026-05-05 Hiun Kim , Tae Kwan Lee , Taeryun Won

Large Language Models (LLMs) have shown promise in highly-specialized domains, however challenges are still present in aspects of accuracy and costs. These limitations restrict the usage of existing models in domain-specific tasks. While…

Computation and Language · Computer Science 2024-10-30 Iftach Arbel , Yehonathan Refael , Ofir Lindenbaum

The deployment of large language models (LLMs) within the healthcare sector has sparked both enthusiasm and apprehension. These models exhibit the remarkable capability to provide proficient responses to free-text queries, demonstrating a…

Computation and Language · Computer Science 2024-07-09 Zabir Al Nazi , Wei Peng