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Combinatorial optimization is widely regarded as a primary application for near-term quantum processors, although a definitive demonstration of the practical quantum advantage remains elusive. Recent studies have reported that both…

Quantum Physics · Physics 2026-05-21 Xian-Zhe Tao , Pavel Mosharev , Man-Hong Yung

In this thesis, we focus on the problem of validating and benchmarking quantum annealers. To this end, we propose two algorithms for solving real-world problems and test how they perform on the current generation of quantum annealers. The…

Quantum Physics · Physics 2023-12-07 Konrad Jałowiecki

Analyzing the relation between a set of biological sequences can help to identify and understand the evolutionary history of these sequences and the functional relations among them. Multiple Sequence Alignment (MSA) is the main obstacle to…

Quantitative Methods · Quantitative Biology 2017-08-07 Sara Shehab , Sameh Shohdy , Arabi E. Keshk

Genetic algorithms are heuristic optimization techniques inspired by Darwinian evolution, which are characterized by successfully finding robust solutions for optimization problems. Here, we propose a subroutine-based quantum genetic…

Quantum Physics · Physics 2024-06-07 Rubén Ibarrondo , Giancarlo Gatti , Mikel Sanz

Quantum annealing is a heuristic quantum optimization algorithm that can be used to solve combinatorial optimization problems. In recent years, advances in quantum technologies have enabled the development of small- and intermediate-scale…

Quantum Physics · Physics 2022-10-05 Sheir Yarkoni , Elena Raponi , Thomas Bäck , Sebastian Schmitt

Rapid development of modern sequencing platforms enabled an unprecedented growth of protein families databases. The abundance of sets composed of hundreds of thousands sequences is a great challenge for multiple sequence alignment…

Genomics · Quantitative Biology 2017-03-03 Sebastin Deorowicz , Agnieszka Debudaj-Grabysz , Adam Gudys

Functions of chemical composition are complex and discrete in nature making it impossible to optimize them with gradient methods. Genetic algorithms, which do not use derivative information, are used to maximize the thermal conductivity of…

Materials Science · Physics 2018-01-30 Alexander Kerr , Kieran Mullen

Quantum annealing allows for quantum fluctuations to be used used to assist in finding the solution to some of the worlds most challenging computational problems. Recently, this field has attracted much interest because of the construction…

Quantum Physics · Physics 2022-07-26 Nicholas Chancellor

Recent advancements in quantum computing suggest the potential to revolutionize computational algorithms across various scientific domains including oceanography and atmospheric science. The field is still relatively young and quantum…

Quantum Physics · Physics 2026-03-24 Takuro Matsuta , Ryo Furue

The recent availability of quantum annealers as cloud-based services has enabled new ways to handle machine learning problems, and several relevant algorithms have been adapted to run on these devices. In a recent work, linear regression…

Quantum Physics · Physics 2025-03-18 Costantino Carugno , Maurizio Ferrari Dacrema , Paolo Cremonesi

The alignment of biological sequences such as DNA, RNA, and proteins, is one of the basic tools that allow to detect evolutionary patterns, as well as functional/structural characterizations between homologous sequences in different…

Quantitative Methods · Quantitative Biology 2023-05-01 Louise Budzynski , Andrea Pagnani

Quantum annealing (QA) has been proposed as a quantum enhanced optimization heuristic exploiting tunneling. Here, we demonstrate how finite range tunneling can provide considerable computational advantage. For a crafted problem designed to…

We propose a variational quantum implementation of self-attention (QSA), the core operation in transformers and large language models, which predicts future elements of a sequence by forming overlap-weighted combinations of past data. At…

Quantum Physics · Physics 2026-02-09 Alessio Pecilli , Matteo Rosati

Quantum annealing approximately solves combinatorial optimization problems by leveraging the principles of adiabatic quantum systems. In this approach, the system's Hamiltonian evolves from an initial general state to a problem-specific…

Quantum annealing is a generic name of quantum algorithms to use quantum-mechanical fluctuations to search for the solution of optimization problem. It shares the basic idea with quantum adiabatic evolution studied actively in quantum…

Quantum Physics · Physics 2009-11-13 Satoshi Morita , Hidetoshi Nishimori

In recent years, machine learning and deep learning have driven advances in domains such as image classification, speech recognition, and anomaly detection by leveraging multi-layer neural networks to model complex data. Simultaneously,…

Quantum Physics · Physics 2025-11-25 Hibah Agha , Samuel Yen-Chi Chen , Huan-Hsin Tseng , Shinjae Yoo

Motivation: The multiple sequence alignment (MSA) problem has been extensively studied, with numerous approaches developed over recent years. With the rapid growth of sequence data, there is an increasing need for fast and accurate MSA…

Computational Engineering, Finance, and Science · Computer Science 2026-01-23 Emily G. Light , Morgan Prior , Noah M. Daniels , Najib Ishaq

Modern quantum annealers can find high-quality solutions to combinatorial optimisation objectives given as quadratic unconstrained binary optimisation (QUBO) problems. Unfortunately, obtaining suitable QUBO forms in computer vision remains…

Quantum computing is emerging as a new computing resource that could be superior to conventional computing for certain classes of optimization problems. However, in principle, most existing approaches to quantum optimization are intended to…

Optimization and Control · Mathematics 2022-01-21 Chin-Yao Chang , Eric Jones , Yiyun Yao , Peter Graf , Rishabh Jain

Quantum computing promises to solve difficult optimization problems in chemistry, physics and mathematics more efficiently than classical computers, but requires fault-tolerant quantum computers with millions of qubits. To overcome errors…

Databases · Computer Science 2021-07-23 Tobias Fankhauser , Marc E. Solèr , Rudolf M. Füchslin , Kurt Stockinger
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