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I describe how real quantum annealers may be used to perform local (in state space) searches around specified states, rather than the global searches traditionally implemented in the quantum annealing algorithm. The quantum annealing…

Emerging Technologies · Computer Science 2016-06-23 Nicholas Chancellor

Quantum annealing is a heuristic optimization algorithm that exploits quantum evolution to approximately find lowest energy states. Quantum annealers have scaled up in recent years to tackle increasingly larger and more highly connected…

Quantum Physics · Physics 2025-07-04 Humberto Munoz Bauza , Daniel A. Lidar

Optimizing the mRNA codon has an essential impact on gene expression for a specific target protein. It is an NP-hard problem; thus, exact solutions to such optimization problems become computationally intractable for realistic problem sizes…

Quantum Physics · Physics 2024-05-13 Hongfeng Zhang , Aritra Sarkar , Koen Bertels

Quantum algorithms for combinatorial optimization typically encode constraints as soft penalties within the objective function, which can reduce efficiency and scalability compared to state-of-the-art classical methods that instead exploit…

Quantum Physics · Physics 2025-11-20 Matteo Vandelli , Francesco Ferrari , Daniele Dragoni

Mixed discrete-continuous optimization is central to engineering design, where discrete choices interact with continuous fields. These problems are difficult due to high-dimensional, complex search spaces. To tackle them, Quantum Annealing…

Computational Engineering, Finance, and Science · Computer Science 2026-03-19 Fabian Key , Lukas Freinberger , Mayu Muramatsu , Norbert Hosters

CA has grown as potential classifier for addressing major problems in bioinformatics. Lot of bioinformatics problems like predicting the protein coding region, finding the promoter region, predicting the structure of protein and many other…

Computational Engineering, Finance, and Science · Computer Science 2014-01-13 Pokkuluri Kiran Sree , Inampudi Ramesh Babu , SSSN Usha Devi Nedunuri

Quantum-classical hybrid algorithms offer a promising strategy for tackling computationally challenging problems, such as the maximum independent set (MIS) problem that plays a crucial role in areas like network design and data analysis.…

Quantum Physics · Physics 2025-06-17 Seokho Jeong , Juyoung Park , Jaewook Ahn

We propose a framework to solve non-linear and history-dependent mechanical problems based on a hybrid classical computer -- quantum annealer approach. Quantum Computers are anticipated to solve particular operations exponentially faster.…

Computational Engineering, Finance, and Science · Computer Science 2024-02-20 Van-Dung Nguyen , Ling Wu , Françoise Remacle , Ludovic Noels

Evolutionary modeling applications are the best way to provide full information to support in-depth understanding of evaluation of organisms. These applications mainly depend on identifying the evolutionary history of existing organisms and…

Computational Engineering, Finance, and Science · Computer Science 2018-06-01 Sara Shehab , Sameh Abdulah , Arabi E. Keshk

We present a classical algorithm to find approximate solutions to instances of quadratic unconstrained binary optimisation. The algorithm can be seen as an analogue of quantum annealing under the restriction of a product state space, where…

Quantum Physics · Physics 2023-02-14 Joseph Bowles , Alexandre Dauphin , Patrick Huembeli , José Martinez , Antonio Acín

We explore the potential application of quantum annealing to address the protein structure problem. To this end, we compare several proposed ab initio protein folding models for quantum computers and analyze their scaling and performance…

Quantum Physics · Physics 2026-04-27 Timon Scheiber , Matthias Heller , Andreas Giebel

Recent advances in DNA sequencing open prospects to make whole-genome analysis rapid and reliable, which is promising for various applications including personalized medicine. However, existing techniques for {\it de novo} genome assembly,…

This paper studies quantum annealing (QA) for clustering, which can be seen as an extension of simulated annealing (SA). We derive a QA algorithm for clustering and propose an annealing schedule, which is crucial in practice. Experiments…

Artificial Intelligence · Computer Science 2014-08-12 Kenichi Kurihara , Shu Tanaka , Seiji Miyashita

This paper studies quantum annealing (QA) for clustering, which can be seen as an extension of simulated annealing (SA). We derive a QA algorithm for clustering and propose an annealing schedule, which is crucial in practice. Experiments…

Disordered Systems and Neural Networks · Physics 2009-05-28 Kenichi Kurihara , Shu Tanaka , Seiji Miyashita

We present a hybrid classical-quantum computing paradigm where the quantum part strictly runs within the coherence time of a quantum annealer, a method we call variational coherent quantum annealing (VCQA). It involves optimizing the…

Quantum Physics · Physics 2023-10-04 N. Barraza , G. Alvarado Barrios , I. Montalban , E. Solano , F. Albarrán-Arriagada

We introduce the reinforcement quantum annealing (RQA) scheme in which an intelligent agent interacts with a quantum annealer that plays the stochastic environment role of learning automata and tries to iteratively find better Ising…

Quantum Physics · Physics 2020-01-03 Ramin Ayanzadeh , Milton Halem , Tim Finin

We investigate the use of quantum computing algorithms on real quantum hardware to tackle the computationally intensive task of feature selection for light-weight medical image datasets. Feature selection is often formulated as a k of n…

Quantum Physics · Physics 2025-02-27 Merlin A. Nau , Luca A. Nutricati , Bruno Camino , Paul A. Warburton , Andreas K. Maier

Finding shape correspondences can be formulated as an NP-hard quadratic assignment problem (QAP) that becomes infeasible for shapes with high sampling density. A promising research direction is to tackle such quadratic optimization problems…

Computer Vision and Pattern Recognition · Computer Science 2021-08-20 Marcel Seelbach Benkner , Zorah Lähner , Vladislav Golyanik , Christof Wunderlich , Christian Theobalt , Michael Moeller

Multiple Sequence Alignment (MSA) is one of the most computationally intensive tasks in Computational Biology. Existing best known solutions for multiple sequence alignment take several hours (in some cases days) of computation time to…

Distributed, Parallel, and Cluster Computing · Computer Science 2009-01-20 Fahad Saeed , Ashfaq Khokhar

In this paper, we introduce stochastic simulated quantum annealing (SSQA) for large-scale combinatorial optimization problems. SSQA is designed based on stochastic computing and quantum Monte Carlo, which can simulate quantum annealing (QA)…

Quantum Physics · Physics 2024-07-25 Naoya Onizawa , Ryoma Sasaki , Duckgyu Shin , Warren J. Gross , Takahiro Hanyu