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Connecting cell behavior to tissue shape and mechanics is a key challenge in the physics of morphogenesis. Cytoskeletal turnover precludes a fixed reference state, and tensions are actively generated independently of strain; so conventional…

Soft Condensed Matter · Physics 2026-05-28 Nikolas H. Claussen , Fridtjof Brauns , Boris I. Shraiman

We study numerically the behaviour of a mixture of a passive isotropic fluid and an active polar gel, in the presence of a surfactant favouring emulsification. Focussing on parameters for which the underlying free energy favours the…

Biological active matter like the cytoskeleton or tissues are characterized by their ability to transform chemical energy into mechanical stress. In addition, it often exhibits orientational order, which is essential for many cellular and…

Biological Physics · Physics 2025-06-05 Ludovic Dumoulin , Carles Blanch-Mercader , Karsten Kruse

From protein motifs to black holes, topological solitons are pervasive nonlinear excitations that are robust and can be driven by external fields. So far, existing driving mechanisms all accelerate solitons and antisolitons in opposite…

Soft solids with tunable mechanical response are at the core of new material technologies, but a crucial limit for applications is their progressive aging over time, which dramatically affects their functionalities. The generally accepted…

Soft Condensed Matter · Physics 2017-08-02 Mehdi Bouzid , Jader Colombo , Lucas Vieira Barbosa , Emanuela Del Gado

Active matter composed of energy-generating microscopic constituents is a promising platform to create autonomous functional materials. However, the very presence of these microscopic energy sources is what makes active matter prone to…

Soft Condensed Matter · Physics 2025-07-15 Martin Brandenbourger , Colin Scheibner , Jonas Veenstra , Vincenzo Vitelli , Corentin Coulais

We consider disordered solids in which the microscopic elements can deform plastically in response to stresses on them. We show that by driving the system periodically, this plasticity can be exploited to train in desired elastic…

Soft Condensed Matter · Physics 2022-06-01 Daniel Hexner , Andrea J. Liu , Sidney R. Nagel

Observations of single epidermal cells on flat adhesive substrates have revealed two distinct morphological and functional states, namely a non-migrating symmetric unpolarized state and a migrating asymmetric polarized state. These states…

Biological Physics · Physics 2010-04-14 Wolfgang Alt , Martin Bock , Christoph Möhl

Topological defects play a central role in the physics of many materials, including magnets, superconductors and liquid crystals. In active fluids, defects become autonomous particles that spontaneously propel from internal active stresses…

Soft Condensed Matter · Physics 2024-06-12 Suraj Shankar , Luca V. D. Scharrer , Mark J. Bowick , M. Cristina Marchetti

The recent finding of collective actuation in active solids, namely solids embedded with active units, opens the path towards multifunctional materials with genuine autonomy. In such systems, collective dynamics emerge spontaneously and…

Soft Condensed Matter · Physics 2023-02-17 Paul Baconnier , Dor Shohat , Olivier Dauchot

We extend a model for the morphology and dynamics of a crawling eukaryotic cell to describe cells on micropatterned substrates. This model couples cell morphology, adhesion, and cytoskeletal flow in response to active stresses induced by…

Cell Behavior · Quantitative Biology 2015-06-17 Brian A. Camley , Yanxiang Zhao , Bo Li , Herbert Levine , Wouter-Jan Rappel

Internal activity can fundamentally reshape the mechanical behavior of solids, yet its role in softening and failure remains incompletely understood. In this study, we investigate spontaneous deformations in activated solids via non-affine…

Soft Condensed Matter · Physics 2026-03-19 Parswa Nath , Debankur Das , Surajit Sengupta , Debasish Chaudhuri

Living soft tissues appear to promote the development and maintenance of a preferred mechanical state within a defined tolerance around a so-called set-point. This phenomenon is often referred to as mechanical homeostasis. In contradiction…

Computational Engineering, Finance, and Science · Computer Science 2021-09-23 Jonas F. Eichinger , Maximilian J. Grill , Iman Davoodi Kermani , Roland C. Aydin , Wolfgang A. Wall , Jay D. Humphrey , Christian J. Cyron

Emergent nonreciprocity in active matter drives the formation of self-organized states that transcend the behaviors of equilibrium systems. Integrating experiments, theory and simulations, we demonstrate that active solids composed of…

Active semiflexible filaments are crucial in various biophysical processes, yet insights into their single-filament behavior have predominantly relied on theory and simulations, owing to the scarcity of controllable synthetic systems. Here,…

Soft Condensed Matter · Physics 2025-07-14 Bipul Biswas , Prasanna More , Hima Nagamanasa Kandula

Many organisms leverage an interplay between shape and activity to generate motion and adapt to their environment. Embedding such feedback into synthetic microrobots could eliminate the need for sensors, software, and actuators, yet current…

Soft Condensed Matter · Physics 2025-06-19 Mengshi Wei , Daniela J. Kraft

Activity and autonomous motion are fundamental in living and engineering systems. This has stimulated the new field of active matter in recent years, which focuses on the physical aspects of propulsion mechanisms, and on motility-induced…

Colloidal particles moving in a fluid interact via the induced velocity field. The collective dynamic state for a class of actively forced colloids, driven by harmonic potentials via a rule that couples forces to configurations, to perform…

Soft Condensed Matter · Physics 2011-10-11 Loïc Damet , Giovanni M. Cicuta , Jurij Kotar , Marco Cosentino Lagomarsino , Pietro Cicuta

The field of active nematics has traditionally employed descriptions based on dipolar activity, with interactions that align along a single axis. However, it has been theoretically predicted that interactions with a substrate, prevalent in…

Biological cells can actively tune their intracellular architecture according to their overall shape. Here we explore the rheological implication of such coupling in a minimal model of a dense cellular material where each cell exerts an…

Soft Condensed Matter · Physics 2022-04-13 Shao-Zhen Lin , Matthias Merkel , Jean-François Rupprecht