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DNA-based data storage has been attracting significant attention due to its extremely high data storage density, low power consumption, and long duration compared to conventional data storage media. Despite the recent advancements in DNA…

Information Theory · Computer Science 2024-11-12 Yi Ding , Xuan He , Tuan Thanh Nguyen , Wentu Song , Zohar Yakhini , Eitan Yaakobi , Linqiang Pan , Xiaohu Tang , Kui Cai

We consider error-correcting coding for DNA-based storage. We model the DNA storage channel as a multi-draw IDS channel where the input data is chunked into $M$ short DNA strands, which are copied a random number of times, and the channel…

Information Theory · Computer Science 2023-06-22 Lorenz Welter , Issam Maarouf , Andreas Lenz , Antonia Wachter-Zeh , Eirik Rosnes , Alexandre Graell i Amat

In this review paper, we delve into the nascent field of molecular data storage, focusing on system implementations and code constructions. We start by providing an overview of basic concepts in synthetic and computational biology.…

Emerging Technologies · Computer Science 2023-10-10 Olgica Milenkovic , Chao Pan

Owing to its immense storage density and durability, DNA has emerged as a promising storage medium. However, due to technological constraints, data can only be written onto many short DNA molecules called data blocks that are stored in an…

Information Theory · Computer Science 2024-03-26 Shubhransh Singhvi , Charchit Gupta , Avital Boruchovsky , Yuval Goldberg , Han Mao Kiah , Eitan Yaakobi

DNA has many valuable characteristics that make it suitable for a long-term storage medium, in particular its durability and high information density. DNA can be stored safely for hundreds of years with virtually no degradation, in contrast…

Quantitative Methods · Quantitative Biology 2022-05-31 Jamie J. Alnasir , Thomas Heinis , Louis Carteron

Deoxyribonucleic acid (DNA) has emerged as a promising building block for next-generation ultra-high density storage devices. Although DNA has high durability and extremely high density in nature, its potential as the basis of storage…

Emerging Technologies · Computer Science 2023-04-28 Arpan De , Hashem Mohammad , Yiren Wang , Rajkumar Kubendran , Arindam K. Das , M. P. Anantram

DNA is a promising storage medium, but its stability and occurrence of Indel errors pose a significant challenge. The relative occurrence of Guanine(G) and Cytosine(C) in DNA is crucial for its longevity, and reverse complementary base…

Information Theory · Computer Science 2024-01-15 NallappaBhavithran G , Selvakumar R

Storing digital data in synthetic DNA faces challenges in ensuring data reliability in the presence of edit errors--deletions, insertions, and substitutions--that occur randomly during various stages of the storage process. Current…

Information Theory · Computer Science 2025-09-11 Serge Kas Hanna

Digital information can be encoded in the building-block sequence of macro-molecules, such as RNA and single-stranded DNA. Methods of "writing" and "reading" macromolecular strands are currently available, but they are slow and expensive.…

Emerging Technologies · Computer Science 2017-09-14 Masud Mansuripur , Pramod Khulbe

Modern biological science produces vast amounts of genomic sequence data. This is fuelling the need for efficient algorithms for sequence compression and analysis. Data compression and the associated techniques coming from information…

Data Structures and Algorithms · Computer Science 2011-09-05 Heba Afify , Muhammad Islam , Manal Abdel Wahed

The coverage depth problem in DNA data storage is about computing the expected number of reads needed to recover all encoded strands. Given a generator matrix of a linear code, this quantity equals the expected number of randomly drawn…

Information Theory · Computer Science 2026-03-09 Matteo Bertuzzo , Alberto Ravagnani , Eitan Yaakobi

Typical large-scale recommender systems use deep learning models that are stored on a large amount of DRAM. These models often rely on embeddings, which consume most of the required memory. We present Bandana, a storage system that reduces…

Machine Learning · Computer Science 2018-11-16 Assaf Eisenman , Maxim Naumov , Darryl Gardner , Misha Smelyanskiy , Sergey Pupyrev , Kim Hazelwood , Asaf Cidon , Sachin Katti

Composite DNA is a recent method to increase the base alphabet size in DNA-based data storage.This paper models synthesizing and sequencing of composite DNA and introduces coding techniques to correct substitutions, losses of entire…

Information Theory · Computer Science 2025-10-29 Frederik Walter , Omer Sabary , Antonia Wachter-Zeh , Eitan Yaakobi

The problem of storing large amounts of information safely for a long period of time has become essential. One of the most promising new data storage mediums are the polymer-based data storage systems, like the DNA-storage system. These…

Information Theory · Computer Science 2025-04-21 Ville Junnila , Tero Laihonen , Tuomo Lehtilä

In the emerging field of DNA storage, data is encoded as DNA sequences and stored. The data is read out again by sequencing the stored DNA. Nanopore sequencing is a new sequencing technology that has many advantages over other methods; in…

Information Theory · Computer Science 2021-02-04 Reyna Hulett , Shubham Chandak , Mary Wootters

DNA storage has emerged as an important area of research. The reliability of DNA storage system depends on designing the DNA strings (called DNA codes) that are sufficiently dissimilar. In this work, we introduce DNA codes that satisfy a…

Information Theory · Computer Science 2022-11-28 Krishna Gopal Benerjee , Sourav Deb , Manish K Gupta

Encoding digital information into DNA sequences offers an attractive potential solution for storing rapidly growing data under the information age and the rise of artificial intelligence. However, practical implementations of DNA storage…

Information Theory · Computer Science 2026-01-26 Zimu Li , Bingyi Liu , Lei Zhao , Qian Zhang , Yang Liu , Jun Liu , Ke Ke , Huating Kong , Xiaolei Zuo , Chunhai Fan , Fei Wang

Deoxyribonucleic Acid (DNA), with its high density and long durability, is a promising storage medium for long-term archival storage and has attracted much attention. Several studies have verified the feasibility of using DNA for archival…

Emerging Technologies · Computer Science 2022-09-15 Yixun Wei , Bingzhe Li , David H. C. Du

A method for encoding information in DNA sequences is described. The method is based on the precision-resolution framework, and is aimed to work in conjunction with a recently suggested terminator-free template independent DNA synthesis…

Information Theory · Computer Science 2020-05-14 Siddharth Jain , Farzad Farnoud , Moshe Schwartz , Jehoshua Bruck

DNA emerges as a promising medium for the exponential growth of digital data due to its density and durability. This study extends recent research by addressing the \emph{coverage depth problem} in practical scenarios, exploring optimal…

Information Theory · Computer Science 2024-02-01 Hadas Abraham , Rayn Gabrys , Eitan Yaakobi