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The definition of an innovative therapeutic protocol requires the fine tuning of all the involved operations in order to maximize the efficiency. In some cases, the price of the experiments, or their duration, represents a great obstacle…

Quantitative Methods · Quantitative Biology 2019-07-26 Daniele Peri , Manon Deville , Clair Poignard , Emanuela Signori , Roberto Natalini

The Expectation-Maximization (EM) algorithm is an iterative method to maximize the log-likelihood function for parameter estimation. Previous works on the convergence analysis of the EM algorithm have established results on the asymptotic…

Statistics Theory · Mathematics 2017-05-31 Chong Wu , Can Yang , Hongyu Zhao , Ji Zhu

We pursue a computational analysis of the biomedical problem on the identification of the cancerous tumor at an early stage of development based on the Electrical Impedance Tomography (EIT) and optimal control of elliptic partial…

Optimization and Control · Mathematics 2025-09-03 Ugur G. Abdulla , Jose H. Rodrigues

We present a novel formulation of ergodic trajectory optimization that can be specified over general domains using kernel maximum mean discrepancy. Ergodic trajectory optimization is an effective approach that generates coverage paths for…

Robotics · Computer Science 2025-12-08 Christian Hughes , Houston Warren , Darrick Lee , Fabio Ramos , Ian Abraham

Expectation propagation (EP) is a deterministic approximation algorithm that is often used to perform approximate Bayesian parameter learning. EP approximates the full intractable posterior distribution through a set of local approximations…

Machine Learning · Statistics 2015-11-19 Yingzhen Li , Jose Miguel Hernandez-Lobato , Richard E. Turner

Electronic excitations and ionisations produced by electron impact are key processes in the radiation-induced damage mechanisms in materials of biological relevance, underlying important medical and technological applications, including…

Chemical Physics · Physics 2021-08-04 Pablo de Vera , Isabel Abril , Rafael Garcia-Molina

This two-part paper develops a non-iterative coordinated optimal dispatch framework, i.e., free of iterative information exchange, via the innovation of the equivalent projection (EP) theory. The EP eliminates internal variables from…

Optimization and Control · Mathematics 2025-10-27 Zhenfei Tan , Zheng Yan , Haiwang Zhong , Qing Xia

Since a long time the application of small electric potentials on biological membranes (iontophoresis) proved enabling control and improvement of transdermal delivery of substances across this barrier. In spite of a large experimental data,…

Tissues and Organs · Quantitative Biology 2019-05-07 Neila Machado , Clarissa Callegaro , Marcelo Augusto Christoffolete , Herculano Martinho

Accurate exploration of protein conformational ensembles is essential for uncovering function but remains hard because molecular-dynamics (MD) simulations suffer from high computational costs and energy-barrier trapping. This paper presents…

Machine Learning · Computer Science 2025-11-14 Yuancheng Sun , Yuxuan Ren , Zhaoming Chen , Xu Han , Kang Liu , Qiwei Ye

Expectation Propagation (EP) is a widely used iterative message-passing algorithm that decomposes a global inference problem into multiple local ones. It approximates marginal distributions as ``beliefs'' using intermediate functions called…

Machine Learning · Statistics 2026-04-07 Zilu Zhao , Jichao Chen , Dirk Slock

Background: Intensity-modulated proton therapy (IMPT) using pencil beam technique scans tumor in a layer by layer, then spot by spot manner. It can provide highly conformal dose to tumor targets and spare nearby organs-at-risk (OAR). Fast…

Medical Physics · Physics 2024-11-28 Aoxiang Wang , Ya-Nan Zhu , Jufri Setianegara , Yuting Lin , Peng Xiao , Qingguo Xie , Hao Gao

Extracellular electrical potentials (EEP) recorded from the brain are an active manifestation of all cellular processes that propagate within a volume of brain tissue. A standard approach for their quantification are power spectral analyses…

Neurons and Cognition · Quantitative Biology 2020-11-17 Shailaja Akella , Ali Mohebi , Kiersten Riels , Andreas Keil , Karim Oweiss , Jose C. Principe

We study the trajectory optimization problem under chance constraints for continuous-time stochastic systems. To address chance constraints imposed on the entire stochastic trajectory, we propose a framework based on the set erosion…

Optimization and Control · Mathematics 2025-04-08 Zishun Liu , Liqian Ma , Yongxin Chen

Electromagnetically-induced transparency (EIT) has been proposed as a way to greatly enhance cross-phase modulation, with the possibility of leading to few-photon-level optical nonlinearities. This enhancement grows as the transparency…

Atomic Physics · Physics 2016-01-27 Amir Feizpour , Greg Dmochowski , Aephraim M. Steinberg

Exceptional points (EP) are non-Hermitian spectral degeneracies where both eigenvalues and their corresponding eigenvectors coalesce. Recently, EPs have attracted a lot of attention as a means to enhance the responsivity of sensors, via the…

Applied Physics · Physics 2022-02-22 Rodion Kononchuk , Jizhe Cai , Fred Ellis , Ramathasan Thevamaran , Tsampikos Kottos

Exceptional points (EPs) in non-Hermitian systems have recently attracted wide interests and spawned intriguing prospects for enhanced sensing. However, EPs have not yet been realized in thermal atomic ensembles, which is one of the most…

Quantum Physics · Physics 2023-06-30 Chao Liang , Yuanjiang Tang , An-Ning Xu , Yong-Chun Liu

Gaussian process regression has recently emerged as a powerful, system-agnostic tool for building global potential energy surfaces (PES) of polyatomic molecules. While the accuracy of GP models of PES increases with the number of potential…

Chemical Physics · Physics 2019-07-23 Jun Dai , Roman V. Krems

Electrical impedance tomography (EIT) is a non-invasive imaging method in which an unknown physical body is probed with electric currents applied on the boundary, and the internal conductivity distribution is recovered from the measured…

Numerical Analysis · Mathematics 2014-02-07 Sarah Jane Hamilton , Samuli Siltanen

Under the most common experimental conditions, the adsorption of proteins to solid surfaces is an spontaneous process that leads to a rather compact layer of randomly oriented molecules. Due to the importance of this process for the…

Soft Condensed Matter · Physics 2022-06-29 Sergio A. Urzúa , Perla Y. Sauceda-Oloño , Carlos D. García , Christopher D. Cooper

Influence of pulsed electric field (PEF) simultaneous to pressure treatment on moisture expression from fine-cut cellular raw material has been investigated. Dependencies of specific conductivity $\sigma$, liquid yield $Y$, instantaneous…

Biological Physics · Physics 2007-05-23 M. I. Bazhal , N. I. Lebovka , E. I. Vorobiev