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Related papers: Bridging Text and Molecule: A Survey on Multimodal…

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Cross-modal text-molecule retrieval task bridges molecule structures and natural language descriptions. Existing methods predominantly focus on aligning text modality and molecule modality, yet they overlook adaptively adjusting the…

Computation and Language · Computer Science 2025-02-18 Hongyan Wu , Peijian Zeng , Weixiong Zheng , Lianxi Wang , Nankai Lin , Shengyi Jiang , Aimin Yang

Multimodal large language models (MLLMs) have made impressive progress in many applications in recent years. However, chemical MLLMs that can handle cross-modal understanding and generation remain underexplored. To fill this gap, we propose…

Machine Learning · Computer Science 2025-08-05 Qian Tan , Dongzhan Zhou , Peng Xia , Wanhao Liu , Wanli Ouyang , Lei Bai , Yuqiang Li , Tianfan Fu

Reasoning is central to human intelligence, enabling structured problem-solving across diverse tasks. Recent advances in large language models (LLMs) have greatly enhanced their reasoning abilities in arithmetic, commonsense, and symbolic…

The advent of Large Language Models (LLMs) has significantly reshaped the trajectory of the AI revolution. Nevertheless, these LLMs exhibit a notable limitation, as they are primarily adept at processing textual information. To address this…

Computer Vision and Pattern Recognition · Computer Science 2025-10-15 Akash Ghosh , Arkadeep Acharya , Sriparna Saha , Vinija Jain , Aman Chadha

We introduce a novel framework for evaluating multimodal deep learning models with respect to their language understanding and generalization abilities. In this approach, artificial data is automatically generated according to the…

Computation and Language · Computer Science 2017-04-18 Alexander Kuhnle , Ann Copestake

Machine learning (ML) is transforming all areas of science. The complex and time-consuming calculations in molecular simulations are particularly suitable for a machine learning revolution and have already been profoundly impacted by the…

Chemical Physics · Physics 2019-11-11 Frank Noé , Alexandre Tkatchenko , Klaus-Robert Müller , Cecilia Clementi

Multimodal machine learning is a vibrant multi-disciplinary research field that aims to design computer agents with intelligent capabilities such as understanding, reasoning, and learning through integrating multiple communicative…

Machine Learning · Computer Science 2023-02-21 Paul Pu Liang , Amir Zadeh , Louis-Philippe Morency

A drug molecule is a substance that changes the organism's mental or physical state. Every approved drug has an indication, which refers to the therapeutic use of that drug for treating a particular medical condition. While the Large…

Artificial Intelligence · Computer Science 2024-02-20 David Oniani , Jordan Hilsman , Chengxi Zang , Junmei Wang , Lianjin Cai , Jan Zawala , Yanshan Wang

Strong Artificial Intelligence (Strong AI) or Artificial General Intelligence (AGI) with abstract reasoning ability is the goal of next-generation AI. Recent advancements in Large Language Models (LLMs), along with the emerging field of…

Computation and Language · Computer Science 2024-01-19 Yiqi Wang , Wentao Chen , Xiaotian Han , Xudong Lin , Haiteng Zhao , Yongfei Liu , Bohan Zhai , Jianbo Yuan , Quanzeng You , Hongxia Yang

Molecular machine learning has been maturing rapidly over the last few years. Improved methods and the presence of larger datasets have enabled machine learning algorithms to make increasingly accurate predictions about molecular…

Predicting whether a molecule can cross the blood-brain barrier (BBB) is a key step in early-stage neuro-pharmaceutical design, directly influencing the efficiency and success rate of drug development. Traditional methods based on…

Quantitative Methods · Quantitative Biology 2026-03-16 Zihan Yang , Yuchen Xiao

The remarkable success of Large Language Models (LLMs) across diverse tasks has driven the research community to extend their capabilities to molecular applications. However, most molecular LLMs employ adapter-based architectures that do…

Computation and Language · Computer Science 2025-06-24 Shuhan Guo , Yatao Bian , Ruibing Wang , Nan Yin , Zhen Wang , Quanming Yao

Text embedding has become a foundational technology in natural language processing (NLP) during the deep learning era, driving advancements across a wide array of downstream tasks. While many natural language understanding challenges can…

Computation and Language · Computer Science 2025-10-22 Zhijie Nie , Zhangchi Feng , Mingxin Li , Cunwang Zhang , Yanzhao Zhang , Dingkun Long , Richong Zhang

Topic modelling has been a successful technique for text analysis for almost twenty years. When topic modelling met deep neural networks, there emerged a new and increasingly popular research area, neural topic models, with over a hundred…

Machine Learning · Computer Science 2021-03-02 He Zhao , Dinh Phung , Viet Huynh , Yuan Jin , Lan Du , Wray Buntine

Recent advances in artificial intelligence, particularly large language models LLMs, have shown promising capabilities in transforming rare disease research. This survey paper explores the integration of LLMs in the analysis of rare…

Computation and Language · Computer Science 2025-05-26 Valentina Carbonari , Pierangelo Veltri , Pietro Hiram Guzzi

This survey discusses how recent developments in multimodal processing facilitate conceptual grounding of language. We categorize the information flow in multimodal processing with respect to cognitive models of human information processing…

Computation and Language · Computer Science 2019-07-04 Lisa Beinborn , Teresa Botschen , Iryna Gurevych

This research paper addresses the challenge of modality mismatch in multimodal learning, where the modalities available during inference differ from those available at training. We propose the Text-centric Alignment for Multi-Modality…

Machine Learning · Computer Science 2024-05-22 Yun-Da Tsai , Ting-Yu Yen , Pei-Fu Guo , Zhe-Yan Li , Shou-De Lin

Large Language Models (LLMs) with their strong task-handling capabilities have shown remarkable advancements across a spectrum of fields, moving beyond natural language understanding. However, their proficiency within the chemistry domain…

Computer Vision and Pattern Recognition · Computer Science 2026-02-02 Khiem Le , Zhichun Guo , Kaiwen Dong , Xiaobao Huang , Bozhao Nan , Roshni Iyer , Xiangliang Zhang , Olaf Wiest , Wei Wang , Ting Hua , Nitesh V. Chawla

In recent years, AI models that mine intrinsic patterns from molecular structures and protein sequences have shown promise in accelerating drug discovery. However, these methods partly lag behind real-world pharmaceutical approaches of…

Machine Learning · Computer Science 2023-10-17 Yizhen Luo , Xing Yi Liu , Kai Yang , Kui Huang , Massimo Hong , Jiahuan Zhang , Yushuai Wu , Zaiqing Nie

Deep learning has significantly advanced molecular modeling and design, enabling efficient understanding and discovery of novel molecules. In particular, large language models (LLMs) introduce a fresh research paradigm to tackle scientific…

Machine Learning · Computer Science 2025-01-06 Pengfei Liu , Jun Tao , Zhixiang Ren
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