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An adult human body is made up of some 30 to 40 trillion cells, all of which stem from a single fertilized egg cell. The process by which the right cells appear to arrive in their right numbers at the right time at the right place --…

Subcellular Processes · Quantitative Biology 2024-12-20 Sean T. Vittadello , Léo Diaz , Yujing Liu , Adriana Zanca , Michael P. H. Stumpf

The use of floating bipolar electrodes in copper electro-winning cells represents an emerging technology that promises economic and operational impacts. This thesis presents EWCellCAD, a computational tool designed for the simulation and…

Graphics · Computer Science 2026-01-14 César Mena

A discrete solid-on-solid model of epitaxial growth is introduced which, in a simple manner, takes into account the effect of an Ehrlich-Schwoebel barrier at step edges as well as the local relaxation of incoming particles. Furthermore a…

Condensed Matter · Physics 2009-10-30 M. Biehl , W. Kinzel , S. Schinzer

We introduce a model of a randomly growing interface in multidimensional Euclidean space. The growth model incorporates a random order model as an ingredient of its graphical construction, in a way that replicates the connection between the…

Probability · Mathematics 2007-09-12 Timo Seppäläinen

Cell fate decisions emerge as a consequence of a complex set of gene regulatory networks. Models of these networks are known to have more parameters than data can determine. Recent work, inspired by Waddington's metaphor of a landscape, has…

Quantitative Methods · Quantitative Biology 2023-05-08 Archishman Raju , Eric D. Siggia

Understanding cell fate patterning and morphogenesis in the mammalian embryo remains a formidable challenge. Recently, in vivo models based on embryonic stem cells (ESCs) have emerged as complementary methods to quantitatively dissect the…

Tissues and Organs · Quantitative Biology 2017-12-12 Eric D. Siggia , Aryeh Warmflash

The organization of cells within tissues plays a vital role in various biological processes, including development and morphogenesis. As a result, understanding how cells self-organize in tissues has been an active area of research. In our…

Soft Condensed Matter · Physics 2023-10-09 Kanaya Malakar , Rafael I. Rubenstein , Dapeng Bi , Bulbul Chakraborty

The Pentagon Model is an explicit supersymmetric extension of the Standard Model, which involves a new strongly-interacting SU(5) gauge theory at TeV-scale energies. We show that the Pentagon can be embedded into an SU(5) x SU(5) x SU(5)…

High Energy Physics - Theory · Physics 2009-11-18 T. Banks , S. Echols , J. L. Jones

The traditional methods of the biology, based on illustrative descriptions and linear logic explanations, are discussed. This work aims to improve this approach by introducing alternative tools to describe and represent complex biological…

Computational Engineering, Finance, and Science · Computer Science 2012-01-24 Alvaro Juan Ojeda Garcia

We study the eigenspectrum properties of a one-dimensional molecular chain composed of hexagonal unit cells. The system features two alternating hopping parameters, resulting in a rich energy spectrum with both dispersive and flat bands. By…

Mesoscale and Nanoscale Physics · Physics 2026-05-13 M. Niţă

Cell colonies of bacteria, tumour cells and fungi, under nutrient limited growth conditions, exhibit complex branched growth patterns. In order to investigate this phenomenon we present a simple hybrid cellular automaton model of cell…

Biological Physics · Physics 2007-05-23 P. Gerlee , A. R. A Anderson

Mathematical and computational models can assist in gaining an understanding of cell behavior at many levels of organization. Here, we review models in the literature that focus on eukaryotic cell motility at 3 size scales: intracellular…

Cell Behavior · Quantitative Biology 2021-01-27 Andreas Buttenschön , Leah Edelstein-Keshet

This paper deals with a model of cellular growth called "Epigenetic Tracking", whose key features are: i) distinction bewteen "normal" and "driver" cells; ii) presence in driver cells of an epigenetic memory, that holds the position of the…

Cell Behavior · Quantitative Biology 2009-05-01 Alessandro Fontana

We analyse the axioms of Euclidean geometry according to standard object-oriented software development methodology. We find a perfect match: the main undefined concepts of the axioms translate to object classes. The result is a suite of C++…

Computational Geometry · Computer Science 2009-09-29 M. H. van Emden , B. Moa

In the present study, we consider the Extra-Membrane-Intra model (EMI) for the simulation of excitable tissues at the cellular level. We provide the (possibly large) system of partial differential equations (PDEs), equipped with ad hoc…

Numerical Analysis · Mathematics 2024-09-23 Pietro Benedusi , Paola Ferrari , Marius Causemann , Stefano Serra-Capizzano

A one-dimensional cellular automaton with a probabilistic evolution rule can generate stochastic surface growth in $(1 + 1)$ dimensions. Two such discrete models of surface growth are constructed from a probabilistic cellular automaton…

Statistical Mechanics · Physics 2015-06-25 Pratip Bhattacharyya

We investigate lamellar three-phase patterns that form during the directional solidification of ternary eutectic alloys in thin samples. A distinctive feature of this system is that many different geometric arrangements of the three phases…

Materials Science · Physics 2015-05-27 Abhik Choudhury , Mathis Plapp , Britta Nestler

Over the last two decades, scientific literature has been blooming with various means of simulating epithelial cell colonies. Each of these simulations can be separated by their respective efficiency (expressed in terms of consumed…

Computational Physics · Physics 2022-12-20 Kevin Höllring , Ana-Sunčana Smith

In order to develop statistical methods for shapes with a tree-structure, we construct a shape space framework for tree-like shapes and study metrics on the shape space. This shape space has singularities, corresponding to topological…

Methodology · Statistics 2012-07-24 Aasa Feragen , Pechin Lo , Marleen de Bruijne , Mads Nielsen , Francois Lauze

Congruent polygons are congruent in angles as well as in edge lengths. We concentrate on the angle aspect, and investigate how tilings of the sphere by congruent pentagons can be determined by the angle information only. We also investigate…

Combinatorics · Mathematics 2026-04-29 Robert Barish , Hoi Ping Luk , Min Yan