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Deep generative modeling has emerged as a powerful tool for synthesizing realistic medical images, driving advances in medical image analysis, disease diagnosis, and treatment planning. This chapter explores various deep generative models…

Image and Video Processing · Electrical Eng. & Systems 2024-10-24 Paul Friedrich , Yannik Frisch , Philippe C. Cattin

Generative AI models are increasingly being integrated into human task workflows, enabling the production of expressive content across a wide range of contexts. Unlike traditional human-AI design methods, the new approach to designing…

Human-Computer Interaction · Computer Science 2025-04-01 Hari Subramonyam , Divy Thakkar , Andrew Ku , Jürgen Dieber , Anoop Sinha

Inverse design optimization aims to infer system parameters from observed solutions, posing critical challenges across domains such as semiconductor manufacturing, structural engineering, materials science, and fluid dynamics. The lack of…

Artificial Intelligence · Computer Science 2025-10-16 Haoyu Yang , Kamyar Azizzadenesheli , Haoxing Ren

Soft robotics has emerged as a promising field with the potential to revolutionize industries such as healthcare and manufacturing. However, designing effective soft robots presents challenges, particularly in managing the complex interplay…

Robotics · Computer Science 2024-05-06 Wee Kiat Chan , PengWei Wang , Raye Chen-Hua Yeow

Deep generative models have proven useful for automatic design synthesis and design space exploration. However, they face three challenges when applied to engineering design: 1) generated designs lack diversity, 2) it is difficult to…

Machine Learning · Computer Science 2020-07-10 Wei Chen , Faez Ahmed

Generative AI is revolutionizing engineering design practices by enabling rapid prototyping and manipulation of designs. One example of design manipulation involves taking two reference design images and using them as prompts to generate a…

Machine Learning · Computer Science 2024-12-23 Yan-Ying Chen , Nikos Arechiga , Chenyang Yuan , Matthew Hong , Matt Klenk , Charlene Wu

A main challenge in mechanical design is to efficiently explore the design space while satisfying engineering constraints. This work explores the use of 3D generative models to explore the design space in the context of vehicle development,…

Computer Vision and Pattern Recognition · Computer Science 2024-10-28 Hayata Morita , Kohei Shintani , Chenyang Yuan , Frank Permenter

Most earlier 3D structure-based molecular generation approaches follow an atom-wise paradigm, incrementally adding atoms to a partially built molecular fragment within protein pockets. These methods, while effective in designing tightly…

Deep generative models are a class of techniques that train deep neural networks to model the distribution of training samples. Research has fragmented into various interconnected approaches, each of which make trade-offs including…

Machine Learning · Computer Science 2022-03-29 Sam Bond-Taylor , Adam Leach , Yang Long , Chris G. Willcocks

Anomaly detection (AD) plays a pivotal role across diverse domains, including cybersecurity, finance, healthcare, and industrial manufacturing, by identifying unexpected patterns that deviate from established norms in real-world data.…

Machine Learning · Computer Science 2025-06-12 Yang Liu , Jing Liu , Chengfang Li , Rui Xi , Wenchao Li , Liang Cao , Jin Wang , Laurence T. Yang , Junsong Yuan , Wei Zhou

Generative Retrieval (GR) has emerged as a promising paradigm to unify indexing and search within a single probabilistic framework. However, existing approaches suffer from two intrinsic conflicts: (1) an Optimization Blockage, where the…

Information Retrieval · Computer Science 2026-03-12 Xujing Wang , Yufeng Chen , Boxuan Zhang , Jie Zhao , Chao Wei , Cai Xu , Ziyu Guan , Wei Zhao , Weiru Zhang , Xiaoyi Zeng

3D shape generation is a challenging problem due to the high-dimensional output space and complex part configurations of real-world objects. As a result, existing algorithms experience difficulties in accurate generative modeling of 3D…

Computer Vision and Pattern Recognition · Computer Science 2019-06-11 Salman H. Khan , Yulan Guo , Munawar Hayat , Nick Barnes

Condition and structural health monitoring (CM/SHM) is a pivotal component of predictive maintenance (PdM) strategies across diverse industrial sectors, including mechanical rotating machinery, aircraft structures, wind turbines, and civil…

Computational Engineering, Finance, and Science · Computer Science 2026-02-17 Xin Yang , Chen Fang , Yunlai Liao , Jian Yang , Konstantinos Gryllias , Dimitrios Chronopoulos

The rapid advance of generative AI is reshaping the strategic vision for R&D across industries. The unique challenges of pharmaceutical R&D will see applications of generative AI deliver value along the entire value chain from early…

Quantitative Methods · Quantitative Biology 2023-12-21 Guy Doron , Sam Genway , Mark Roberts , Sai Jasti

With the advancement of generative AI, research on its application to 3D model generation has gained traction, particularly in automating the creation of Computer-Aided Design (CAD) files from images. GenCAD is a notable model in this…

Computer Vision and Pattern Recognition · Computer Science 2025-05-30 Chikaha Tsuji , Enrique Flores Medina , Harshit Gupta , Md Ferdous Alam

The fundamental goal of generative drug design is to propose optimized molecules that meet predefined activity, selectivity, and pharmacokinetic criteria. Despite recent progress, we argue that existing generative methods are limited in…

Chemical Physics · Physics 2020-12-17 Julien Horwood , Emmanuel Noutahi

Data scarcity remains a critical bottleneck impeding technological advancements across various domains, including but not limited to medicine and precision agriculture. To address this challenge, we explore the potential of Deep Generative…

Machine Learning · Computer Science 2025-04-16 Marco Salmè , Lorenzo Tronchin , Rosa Sicilia , Paolo Soda , Valerio Guarrasi

Discovering new physical products and processes often demands enormous experimentation and expensive simulation. To design a new product with certain target characteristics, an extensive search is performed in the design space by trying out…

Machine Learning · Statistics 2018-11-16 Phuoc Nguyen , Truyen Tran , Sunil Gupta , Santu Rana , Svetha Venkatesh

AI-driven design problems, such as DNA/protein sequence design, are commonly tackled from two angles: generative modeling, which efficiently captures the feasible design space (e.g., natural images or biological sequences), and model-based…

Generative AI models have made significant progress in automating the creation of 3D shapes, which has the potential to transform car design. In engineering design and optimization, evaluating engineering metrics is crucial. To make…

Machine Learning · Computer Science 2023-06-13 Binyang Song , Chenyang Yuan , Frank Permenter , Nikos Arechiga , Faez Ahmed
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