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The variation in histologic staining between different medical centers is one of the most profound challenges in the field of computer-aided diagnosis. The appearance disparity of pathological whole slide images causes algorithms to become…

Image and Video Processing · Electrical Eng. & Systems 2024-04-05 Martin J. Hetz , Tabea-Clara Bucher , Titus J. Brinker

Until recently, conventional biochemical staining had the undisputed status as well-established benchmark for most biomedical problems related to clinical diagnostics, fundamental research and biotechnology. Despite this role as…

Discriminative classifiers have become a foundational tool in deep learning for medical imaging, excelling at learning separable features of complex data distributions. However, these models often need careful design, augmentation, and…

Computer Vision and Pattern Recognition · Computer Science 2025-08-11 Gian Mario Favero , Parham Saremi , Emily Kaczmarek , Brennan Nichyporuk , Tal Arbel

Prostate cancer diagnosis heavily relies on histopathological evaluation, which is subject to variability. While immunohistochemical staining (IHC) assists in distinguishing benign from malignant tissue, it involves increased work, higher…

Understanding the way cells communicate, co-locate, and interrelate is essential to understanding human physiology. Hematoxylin and eosin (H&E) staining is ubiquitously available both for clinical studies and research. The Colon Nucleus…

Medical image classification has developed rapidly under the impetus of the convolutional neural network (CNN). Due to the fixed size of the receptive field of the convolution kernel, it is difficult to capture the global features of…

Image and Video Processing · Electrical Eng. & Systems 2022-09-22 Xiangzuo Huo , Gang Sun , Shengwei Tian , Yan Wang , Long Yu , Jun Long , Wendong Zhang , Aolun Li

Polarization, as a new optical imaging tool, has been explored to assist in the diagnosis of pathology. Moreover, converting the polarimetric Mueller Matrix (MM) to standardized stained images becomes a promising approach to help…

Image and Video Processing · Electrical Eng. & Systems 2025-03-04 Xiaoyu Zheng , Jing Wen , Jiaxin Zhuang , Yao Du , Jing Cong , Limei Guo , Chao He , Lin Luo , Hao Chen

Virtual histology is an emerging field in biomedicine that enables three-dimensional tissue visualization using X-ray micro-computed tomography. However, the method still lacks the specificity of conventional histology, in which parts of…

Breast Cancer is a major cause of death worldwide among women. Hematoxylin and Eosin (H&E) stained breast tissue samples from biopsies are observed under microscopes for the primary diagnosis of breast cancer. In this paper, we propose a…

Computer Vision and Pattern Recognition · Computer Science 2018-07-26 Aditya Golatkar , Deepak Anand , Amit Sethi

Despite the impressive results of arbitrary image-guided style transfer methods, text-driven image stylization has recently been proposed for transferring a natural image into a stylized one according to textual descriptions of the target…

Computer Vision and Pattern Recognition · Computer Science 2023-12-19 Nisha Huang , Yuxin Zhang , Fan Tang , Chongyang Ma , Haibin Huang , Yong Zhang , Weiming Dong , Changsheng Xu

Deep image restoration models aim to learn a mapping from degraded image space to natural image space. However, they face several critical challenges: removing degradation, generating realistic details, and ensuring pixel-level consistency.…

Computer Vision and Pattern Recognition · Computer Science 2025-07-31 Xinqi Lin , Fanghua Yu , Jinfan Hu , Zhiyuan You , Wu Shi , Jimmy S. Ren , Jinjin Gu , Chao Dong

Histopathological analysis is a cornerstone of cancer diagnosis, with Hematoxylin and Eosin (H&E) staining routinely acquired for every patient to visualize cell morphology and tissue architecture. On the other hand, multiplex…

Computer Vision and Pattern Recognition · Computer Science 2026-03-20 Guillaume Balezo , Roger Trullo , Albert Pla Planas , Etienne Decenciere , Thomas Walter

Computational histopathology image diagnosis becomes increasingly popular and important, where images are segmented or classified for disease diagnosis by computers. While pathologists do not struggle with color variations in slides,…

Image and Video Processing · Electrical Eng. & Systems 2020-07-27 Hanwen Liang , Konstantinos N. Plataniotis , Xingyu Li

Pseudo-healthy image inpainting is an essential preprocessing step for analyzing pathological brain MRI scans. Most current inpainting methods favor slice-wise 2D models for their high in-plane fidelity, but their independence across slices…

Image and Video Processing · Electrical Eng. & Systems 2025-07-25 Dou Hoon Kwark , Shirui Luo , Xiyue Zhu , Yudu Li , Zhi-Pei Liang , Volodymyr Kindratenko

Diffusion models have emerged as state-of-the-art in image generation, but their practical deployment is hindered by the significant computational cost of their iterative denoising process. While existing caching techniques can accelerate…

Computer Vision and Pattern Recognition · Computer Science 2025-11-06 Mingyu Sung , Il-Min Kim , Sangseok Yun , Jae-Mo Kang

Renal pathology, as the gold standard of kidney disease diagnosis, requires doctors to analyze a series of tissue slices stained by H&E staining and special staining like Masson, PASM, and PAS, respectively. These special staining methods…

Image and Video Processing · Electrical Eng. & Systems 2023-09-19 Tao Ma , Chao Zhang , Min Lu , Lin Luo

Recent advancements in image generative foundation models have prioritized quality improvements but often at the cost of increased computational complexity and inference latency. To address this critical trade-off, we introduce HiDream-I1,…

Diffusion models have become a mainstream approach for high-resolution image synthesis. However, directly generating higher-resolution images from pretrained diffusion models will encounter unreasonable object duplication and exponentially…

Computer Vision and Pattern Recognition · Computer Science 2024-04-30 Shen Zhang , Zhaowei Chen , Zhenyu Zhao , Yuhao Chen , Yao Tang , Jiajun Liang

Recent advances in diffusion transformers have shown remarkable generalization in visual synthesis, yet most dense perception methods still rely on text-to-image (T2I) generators designed for stochastic generation. We revisit this paradigm…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Yiqing Shi , Yiren Song , Mike Zheng Shou

While human observers are able to cope with variations in color and appearance of histological stains, digital pathology algorithms commonly require a well-normalized setting to achieve peak performance, especially when a limited amount of…

Computer Vision and Pattern Recognition · Computer Science 2017-08-15 Daniel Bug , Steffen Schneider , Anne Grote , Eva Oswald , Friedrich Feuerhake , Julia Schüler , Dorit Merhof