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Evaluation metrics in machine learning are often hardly taken as loss functions, as they could be non-differentiable and non-decomposable, e.g., average precision and F1 score. This paper aims to address this problem by revisiting the…

Machine Learning · Computer Science 2022-03-01 Tao Huang , Zekang Li , Hua Lu , Yong Shan , Shusheng Yang , Yang Feng , Fei Wang , Shan You , Chang Xu

Probabilistic survival predictions from models trained with Maximum Likelihood Estimation (MLE) can have high, and sometimes unacceptably high variance. The field of meteorology, where the paradigm of maximizing sharpness subject to…

Machine Learning · Computer Science 2019-06-20 Anand Avati , Tony Duan , Sharon Zhou , Kenneth Jung , Nigam H. Shah , Andrew Ng

Deep learning has shown remarkable results for image analysis and is expected to aid individual treatment decisions in health care. To achieve this, deep learning methods need to be promoted from the level of mere associations to being able…

Machine Learning · Computer Science 2022-05-02 Wouter A. C. van Amsterdam , Marinus J. C. Eijkemans

Adopting Convolutional Neural Networks (CNNs) in the daily routine of primary diagnosis requires not only near-perfect precision, but also a sufficient degree of generalization to data acquisition shifts and transparency. Existing CNN…

Computer Vision and Pattern Recognition · Computer Science 2023-06-22 Mara Graziani , Sebastian Otalora , Stephane Marchand-Maillet , Henning Muller , Vincent Andrearczyk

Pacreatic ductal adenocarcinoma (PDAC) remains one of the most lethal forms of cancer, with a five-year survival rate below 10% primarily due to late detection. This research develops and validates a deep learning framework for early PDAC…

Computer Vision and Pattern Recognition · Computer Science 2025-09-12 Dennis Slobodzian , Amir Kordijazi

Machine learning can precisely identify different cancer tumors at any stage by classifying cancerous and healthy samples based on their genomic profile. We have developed novel methods of MLAC (Machine Learning Against Cancer) achieving…

Genomics · Quantitative Biology 2020-09-15 Arash Hooshmand

In the last few years, deep learning classifiers have shown promising results in image-based medical diagnosis. However, interpreting the outputs of these models remains a challenge. In cancer diagnosis, interpretability can be achieved by…

Computer Vision and Pattern Recognition · Computer Science 2021-06-16 Kangning Liu , Yiqiu Shen , Nan Wu , Jakub Chłędowski , Carlos Fernandez-Granda , Krzysztof J. Geras

Proton pencil beam scanning (PBS) treatment planning for head and neck (H&N) cancers is a time-consuming and experience-demanding task where a large number of planning objectives are involved. Deep reinforcement learning (DRL) has recently…

Quantitative Methods · Quantitative Biology 2024-09-19 Qingqing Wang , Chang Chang

Purpose: To determine whether deep learning models can distinguish between breast cancer molecular subtypes based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Materials and methods: In this institutional review…

Computer Vision and Pattern Recognition · Computer Science 2017-12-01 Zhe Zhu , Ehab Albadawy , Ashirbani Saha , Jun Zhang , Michael R. Harowicz , Maciej A. Mazurowski

Osteosarcoma is the most common malignant primary bone tumor. Standard treatment includes pre-operative chemotherapy followed by surgical resection. The response to treatment as measured by ratio of necrotic tumor area to overall tumor area…

Image and Video Processing · Electrical Eng. & Systems 2021-01-06 David Joon Ho , Narasimhan P. Agaram , Peter J. Schueffler , Chad M. Vanderbilt , Marc-Henri Jean , Meera R. Hameed , Thomas J. Fuchs

We present a novel approach to neural response prediction that incorporates higher-order operations directly within convolutional neural networks (CNNs). Our model extends traditional 3D CNNs by embedding higher-order operations within the…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Simone Azeglio , Victor Calbiague Garcia , Guilhem Glaziou , Peter Neri , Olivier Marre , Ulisse Ferrari

The application of natural language processing (NLP) to cancer pathology reports has been focused on detecting cancer cases, largely ignoring precancerous cases. Improving the characterization of precancerous adenomas assists in developing…

Machine Learning · Computer Science 2022-12-13 Yizhen Zhong , Jiajie Xiao , Thomas Vetterli , Mahan Matin , Ellen Loo , Jimmy Lin , Richard Bourgon , Ofer Shapira

Breast cancer remains a leading cause of cancer-related mortality worldwide. Early detection is critical, yet manual histopathology analysis is complex and subject to inter-observer variability. While deep neural network-based diagnostic…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Gul Sheeraz , Qun Chen , Liu Feiyu , Zhou Fengjin

Classification-based image retrieval systems are built by training convolutional neural networks (CNNs) on a relevant classification problem and using the distance in the resulting feature space as a similarity metric. However, in practical…

Computer Vision and Pattern Recognition · Computer Science 2018-10-23 Maxim Pisov , Gleb Makarchuk , Valery Kostjuchenko , Alexandra Dalechina , Andrey Golanov , Mikhail Belyaev

Clear cell renal cell carcinoma (ccRCC) is one of the most common forms of intratumoral heterogeneity in the study of renal cancer. ccRCC originates from the epithelial lining of proximal convoluted renal tubules. These cells undergo…

Image and Video Processing · Electrical Eng. & Systems 2021-07-02 Shiba Kuanar , Vassilis Athitsos , Dwarikanath Mahapatra , Anand Rajan

Estimating the uncertainty of deep learning models in a reliable and efficient way has remained an open problem, where many different solutions have been proposed in the literature. Most common methods are based on Bayesian approximations,…

Machine Learning · Computer Science 2023-10-31 Margerie Huet-Dastarac , Dan Nguyen , Steve Jiang , John Lee , Ana Barragan Montero

Concept-based learning enhances prediction accuracy and interpretability by leveraging high-level, human-understandable concepts. However, existing CBL frameworks do not address survival analysis tasks, which involve predicting event times…

Machine Learning · Computer Science 2025-02-11 Stanislav R. Kirpichenko , Lev V. Utkin , Andrei V. Konstantinov , Natalya M. Verbova

Estimating the causal effect of time-varying treatments on survival outcomes is a challenging task in many domains, particularly in medicine where treatment protocols adapt over time. While recent advances in representation learning have…

Machine Learning · Statistics 2025-05-06 Ayoub Abraich

Sparse representation based classification (SRC) methods have achieved remarkable results. SRC, however, still suffer from requiring enough training samples, insufficient use of test samples and instability of representation. In this paper,…

Quantitative Methods · Quantitative Biology 2019-06-28 Xiao-Hui Yang , Li Tian , Yun-Mei Chen , Li-Jun Yang , Shuang Xu , Wen-Ming Wu

Precise segmentation of residual tumor in breast cancer (PSRTBC) after neoadjuvant chemotherapy is a fundamental key technique in the treatment process of breast cancer. However, achieving PSRTBC is still a challenge, since the breast…

Quantitative Methods · Quantitative Biology 2025-03-07 Yongquan Yang , Jie Chen , Yani Wei , Mohammad Alobaidi , Hong Bu
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