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Chemical design of block copolymers makes it possible to create polymer vesicles with tunable microscopic structure. Here we focus on a model of a vesicle made of smectic liquid-crystalline block copolymers at zero temperature. The vesicle…

Soft Condensed Matter · Physics 2018-12-19 Francesco Serafin , Mark J. Bowick , Sidney R. Nagel

Point-like motile topological defects control the universal dynamics of diverse two-dimensional active nematics ranging from shaken granular rods to cellular monolayers. A comparable understanding in higher dimensions has yet to emerge. We…

We investigate the viscoelastic relaxation to equilibrium of a disordered planar epithelium described using the cell vertex model. In its standard form, the model is formulated as coupled evolution equations for the locations of vertices of…

Biological Physics · Physics 2025-10-27 Natasha Cowley , Christopher K. Revell , Emma Johns , Sarah Woolner , Oliver E. Jensen

Collective cell migration governs a range of physiological and pathological processes, from tissue morphogenesis to cancer invasion, in which topological defects arise as an inevitable consequence of frequent cellular rearrangement and…

Soft Condensed Matter · Physics 2026-04-01 Jiusi Zhang , Chung Wing Chan , Bo Li , Rui Zhang

A nematic liquid crystal confined to the surface of a sphere exhibits topological defects of total charge $+2$ due to the topological constraint. In equilibrium, the nematic field forms four $+1/2$ defects, located at the corners of a…

Soft Condensed Matter · Physics 2020-07-22 Yi-Heng Zhang , Markus Deserno , Zhan-Chun Tu

The equilibrium properties of block copolymer micelles confined in polymer thin films are investigated using self-consistent field theory. The theory is based on a model system consisting of AB diblock copolymers and A homopolymers. Two…

Soft Condensed Matter · Physics 2014-01-16 Jiajia Zhou , An-Chang Shi

We investigate how thin structures change their shape in response to non-mechanical stimuli that can be interpreted as variations in the structure's natural curvature. Starting from the theory of non-Euclidean plates and shells, we derive…

Soft Condensed Matter · Physics 2017-06-08 Matteo Pezzulla , Norbert Stoop , Xin Jiang , Douglas P. Holmes

Thermal fluctuations strongly modify the large length-scale elastic behavior of crosslinked membranes, giving rise to scale-dependent elastic moduli. While thermal effects in flat membranes are well understood, many natural and artificial…

Soft Condensed Matter · Physics 2013-02-19 Jayson Paulose , Gerard A. Vliegenthart , Gerhard Gompper , David R. Nelson

Entangled states are ubiquitous amongst fibrous materials, whether naturally occurring (keratin, collagen, DNA) or synthetic (nanotube assemblies, elastane). A key mechanical characteristic of these systems is their ability to reorganise in…

Rigidity transitions in simple models of confluent cells have been a powerful organizing principle in understanding the dynamics and mechanics of dense biological tissue. In this work we explore the interplay between geometry and rigidity…

Soft Condensed Matter · Physics 2020-07-08 Daniel M. Sussman

Collective cell migration plays a crucial role in many developmental processes that underlie morphogenesis, wound healing, or cancer progression. In such coordinated behaviours, cells are organised in coherent structures and actively…

Soft Condensed Matter · Physics 2021-06-16 Carolina Trenado , Luis L. Bonilla , Alejandro Martínez-Calvo

We derive a continuum mechanical model to capture the morphological changes occurring at the pretumoral stage of epithelial tissues. The proposed model aims to investigate the competition between the bulk elasticity of the epithelium and…

Soft Condensed Matter · Physics 2021-07-27 Antonino Favata , Roberto Paroni , Filippo Recrosi , Giuseppe Tomassetti

We investigate the stress-driven morphological instability of epitaxially growing multilayer films, which are coherent and dislocation-free. We construct a direct elastic analysis, from which we determine the elastic state of the system…

Statistical Mechanics · Physics 2009-11-07 Zhi-Feng Huang , Rashmi C. Desai

Classical elasticity is concerned with bodies that can be modeled as smooth manifolds endowed with a reference metric that represents local equilibrium distances between neighboring material elements. The elastic energy associated with a…

Materials Science · Physics 2015-06-30 Raz Kupferman , Michael Moshe , Jake P. Solomon

Topological defects are ubiquitous on surfaces with orientational order fields. Here, we study equilibrium states generated by the feedback between geometry and nematic order on fluid membranes with an integer topological defect. When the…

Soft Condensed Matter · Physics 2024-11-14 D. J. G. Pearce , C. Thibault , Q. Chaboche , C. Blanch-Mercader

The vertex model is widely used to simulate the mechanical properties of confluent epithelia and other multicellular tissues. This inherently discrete framework allows a Cauchy stress to be attributed to each cell, and its symmetric…

Tissues and Organs · Quantitative Biology 2022-10-10 Oliver E. Jensen , Christopher K. Revell

Topological invariants have proved useful for analyzing emergent function as they characterize a property of the entire system, and are insensitive to local details, disorder, and noise. They support boundary states, which reduce the system…

Statistical Mechanics · Physics 2025-10-10 Jaime Agudo-Canalejo , Evelyn Tang

Understanding the fundamental mechanisms behind plastic instabilities and shear band formation in amorphous media under applied deformation remains a long-standing challenge. Leveraging on the mathematical concept of topology, we revisit…

Soft Condensed Matter · Physics 2025-07-08 Xin Wang , Jin Shang , Yujie Wang , Jie Zhang , Matteo Baggioli

The plastic deformation of crystalline materials can be understood by considering their structural defects such as disclinations and dislocations. Although glasses are also solids, their structure resembles closely the one of a liquid and…

Disordered Systems and Neural Networks · Physics 2023-06-21 Zhen Wei Wu , Yixiao Chen , Wei-Hua Wang , Walter Kob , Limei Xu

Biological cells in living tissues form dynamic patterns with local orientational order and topological defects. Here we demonstrate an approach to produce cell monolayer with the predesigned orientational patterns using human dermal…