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Overdose related to prescription opioids have reached an epidemic level in the US, creating an unprecedented national crisis. This has been exacerbated partly due to the lack of tools for physicians to help predict the risk of whether a…

The United States is experiencing an opioid epidemic, and there were more than 10 million opioid misusers aged 12 or older each year. Identifying patients at high risk of Opioid Use Disorder (OUD) can help to make early clinical…

Opioid use disorder (OUD) continuously poses major public health challenges and social implications worldwide with dramatic rise of opioid dependence leading to potential abuse. Despite that a few pharmacological agents have been approved…

Biomolecules · Quantitative Biology 2023-01-13 Hongsong Feng , Rana Elladki , Jian Jiang , Guo-Wei Wei

The opioid epidemic continues to ravage communities worldwide, straining healthcare systems, disrupting families, and demanding urgent computational solutions. To combat this lethal opioid crisis, graph learning methods have emerged as a…

Machine Learning · Computer Science 2026-02-17 Tianyi Ma , Yiyang Li , Yiyue Qian , Zheyuan Zhang , Zehong Wang , Chuxu Zhang , Yanfang Ye

Motivation: Opioid use disorder (OUD) often arises after prescription opioid exposure and follows transitions among onset, remission, and relapse. Linked EHR-survey resources such as the All of Us Research Program enable stage-specific risk…

Quantitative Methods · Quantitative Biology 2026-01-23 Mengman Wei , Stanislav Listopad , Qian Peng

Opioid use disorder (OUD) is a chronic and relapsing condition that involves the continued and compulsive use of opioids despite harmful consequences. The development of medications with improved efficacy and safety profiles for OUD…

Biomolecules · Quantitative Biology 2023-03-02 Hongsong Feng , Jian Jiang , Guo-Wei Wei

The United States is currently experiencing an unprecedented opioid crisis, and opioid overdose has become a leading cause of injury and death. Effective opioid addiction recovery calls for not only medical treatments, but also behavioral…

Social and Information Networks · Computer Science 2019-12-04 Zhou Yang , Spencer Bradshaw , Rattikorn Hewett , Fang Jin

Opioid Use Disorder (OUD) has reached an epidemic level in the US. Diversion of unused prescription opioids to secondary users and black market significantly contributes to the abuse and misuse of these highly addictive drugs, leading to…

Optimization and Control · Mathematics 2022-10-17 Md Mahmudul Hasan , Tasnim Ibn Faiz , Alicia Sasser Modestino , Gary J. Young , Md. Noor-E-Alam

Nutritional interventions are important for managing chronic health conditions, but current computational methods provide limited support for personalized dietary guidance. We identify three key gaps: (1) dietary pattern studies often…

Computation and Language · Computer Science 2026-01-27 Jiatan Huang , Zheyuan Zhang , Tianyi Ma , Mingchen Li , Yaning Zheng , Yanfang Ye , Chuxu Zhang

The ongoing opioid crisis highlights the urgent need for novel therapeutic strategies that can be rapidly deployed. This study presents a novel approach to identify potential repurposable drugs for the treatment of opioid addiction, aiming…

Molecular Networks · Quantitative Biology 2025-09-25 Chunhuan Zhang , Sean Cottrell , Benjamin Jones , Yueying Zhu , Huahai Qiu , Bengong Zhang , Tianshou Zhou , Jian Jiang

The opioid epidemic is a crisis that has plagued the United States (US) for decades. One central issue is inequitable access to treatment for opioid use disorder (OUD), which puts certain populations at a higher risk of opioid overdose. We…

Physics and Society · Physics 2024-03-14 Joyce Luo , Bartolomeo Stellato

Opioid Use Disorder (OUD) has emerged as a significant global public health issue, with complex multifaceted conditions. Due to the lack of effective treatment options for various conditions, there is a pressing need for the discovery of…

Machine Learning · Computer Science 2023-06-14 Hongsong Feng , Rui Wang , Chang-Guo Zhan , Guo-Wei Wei

Due to the significant resemblance in visual appearance, pill misuse is prevalent and has become a critical issue, responsible for one-third of all deaths worldwide. Pill identification, thus, is a crucial concern needed to be investigated…

Computer Vision and Pattern Recognition · Computer Science 2023-03-20 Anh Duy Nguyen , Huy Hieu Pham , Huynh Thanh Trung , Quoc Viet Hung Nguyen , Thao Nguyen Truong , Phi Le Nguyen

Preoperative opioid use has been reported to be associated with higher preoperative opioid demand, worse postoperative outcomes, and increased postoperative healthcare utilization and expenditures. Understanding the risk of preoperative…

Machine Learning · Computer Science 2022-05-18 Yuming Sun , Jian Kang , Chad Brummett , Yi Li

Diet is central to the epidemic of lifestyle disorders. Accurate and effortless diet logging is one of the significant bottlenecks for effective diet management and calorie restriction. Dish detection from food platters is a challenging…

Opioids are an effective analgesic for acute and chronic pain, but also carry a considerable risk of addiction leading to millions of opioid use disorder (OUD) cases and tens of thousands of premature deaths in the United States yearly.…

Quantitative Methods · Quantitative Biology 2024-03-27 Sybille Légitime , Kaustubh Prabhu , Devin McConnell , Bing Wang , Dipak K. Dey , Derek Aguiar

The opioid epidemic, referring to the growing hospitalizations and deaths because of overdose of opioid usage and addiction, has become a severe health problem in the United States. Many strategies have been developed by the federal and…

Computation and Language · Computer Science 2024-09-11 Yuchen Wang , Zhengyu Fang , Wei Du , Shuai Xu , Rong Xu , Jing Li

Drug overdose remains a critical global health issue, often driven by misuse of opioids, painkillers, and psychiatric medications. Traditional research methods face limitations, whereas social media offers real-time insights into…

Computation and Language · Computer Science 2025-07-16 Muhammad Ahmad , Fida Ullah , Muhammad Usman , Umyh Habiba , ldar Batyrshin , Grigori Sidorov

Linear constrained optimization techniques have been applied to many real-world settings. In recent years, inferring the unknown parameters and functions inside an optimization model has also gained traction. This inference is often based…

Optimization and Control · Mathematics 2020-10-16 Farzin Ahmadi , Fardin Ganjkhanloo , Kimia Ghobadi

There were over 70,000 drug overdose deaths in the USA in 2017. Almost half of those involved the use of Opioids such as Heroin. This research supports efforts to combat the Opioid Epidemic by further understanding factors that lead to…

Neural and Evolutionary Computing · Computer Science 2021-03-24 Sean-Kelly Palicki , R. Muhammad Atif Azad
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