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Related papers: MolBind: Multimodal Alignment of Language, Molecul…

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Graph based molecular representation learning is essential for accurately predicting molecular properties in drug discovery and materials science; however, it faces significant challenges due to the intricate relationships among molecules…

Computational Engineering, Finance, and Science · Computer Science 2025-05-28 Zhengyang Zhou , Yunrui Li , Pengyu Hong , Hao Xu

Advancements in prompt tuning of vision-language models have underscored their potential in enhancing open-world visual concept comprehension. However, prior works only primarily focus on single-mode (only one prompt for each modality) and…

Computer Vision and Pattern Recognition · Computer Science 2023-10-27 Dongsheng Wang , Miaoge Li , Xinyang Liu , MingSheng Xu , Bo Chen , Hanwang Zhang

Multi-modal Contrastive Representation learning aims to encode different modalities into a semantically aligned shared space. This paradigm shows remarkable generalization ability on numerous downstream tasks across various modalities.…

Machine Learning · Computer Science 2023-10-20 Zehan Wang , Yang Zhao , Xize Cheng , Haifeng Huang , Jiageng Liu , Li Tang , Linjun Li , Yongqi Wang , Aoxiong Yin , Ziang Zhang , Zhou Zhao

Multimodal retrieval, which seeks to retrieve relevant content across modalities such as text or image, supports applications from AI search to contents production. Despite the success of separate-encoder approaches like CLIP align…

Computation and Language · Computer Science 2025-10-20 Qiyu Wu , Shuyang Cui , Satoshi Hayakawa , Wei-Yao Wang , Hiromi Wakaki , Yuki Mitsufuji

We introduce MM-Mixing, a multi-modal mixing alignment framework for 3D understanding. MM-Mixing applies mixing-based methods to multi-modal data, preserving and optimizing cross-modal connections while enhancing diversity and improving…

Computer Vision and Pattern Recognition · Computer Science 2024-08-20 Jiaze Wang , Yi Wang , Ziyu Guo , Renrui Zhang , Donghao Zhou , Guangyong Chen , Anfeng Liu , Pheng-Ann Heng

The emoticons are symbolic representations that generally accompany the textual content to visually enhance or summarize the true intention of a written message. Although widely utilized in the realm of social media, the core semantics of…

Computer Vision and Pattern Recognition · Computer Science 2024-08-06 Ananya Pandey , Dinesh Kumar Vishwakarma

Virtual screening can accelerate drug discovery by identifying promising candidates for experimental evaluation. Machine learning is a powerful method for screening, as it can learn complex structure-property relationships from experimental…

Machine Learning · Computer Science 2021-02-22 Simon Axelrod , Rafael Gomez-Bombarelli

Protein language models often take into consideration the alignment between a protein sequence and its textual description. However, they do not take structural information into consideration. Traditional methods treat sequence and…

Machine Learning · Computer Science 2026-03-10 Aditya Ranganath , Hasin Us Sami , Kowshik Thopalli , Bhavya Kailkhura , Wesam Sakla

Molecular Relational Learning (MRL) aims to understand interactions between molecular pairs, playing a critical role in advancing biochemical research. With the recent development of large language models (LLMs), a growing number of studies…

Machine Learning · Computer Science 2025-06-03 Zhuo Chen , Yizhen Zheng , Huan Yee Koh , Hongxin Xiang , Linjiang Chen , Wenjie Du , Yang Wang

Structure-based drug design (SBDD) aims to efficiently discover high-affinity ligands within vast chemical spaces. However, current generative models struggle with objective misalignment and rigid sampling budgets. We present MolFORM, a…

Computational Engineering, Finance, and Science · Computer Science 2026-02-26 Daiheng Zhang , Zhao Zhang

Pretraining molecular representations is crucial for drug and material discovery. Recent methods focus on learning representations from geometric structures, effectively capturing 3D position information. Yet, they overlook the rich…

Machine Learning · Computer Science 2024-11-19 Teng Xiao , Chao Cui , Huaisheng Zhu , Vasant G. Honavar

Molecular graph representation learning is widely used in chemical and biomedical research. While pre-trained 2D graph encoders have demonstrated strong performance, they overlook the rich molecular domain knowledge associated with…

Machine Learning · Computer Science 2025-10-09 Xingtong Yu , Chang Zhou , Xinming Zhang , Yuan Fang

We present a new pre-training strategy called M$^{3}$3D ($\underline{M}$ulti-$\underline{M}$odal $\underline{M}$asked $\underline{3D}$) built based on Multi-modal masked autoencoders that can leverage 3D priors and learned cross-modal…

Computer Vision and Pattern Recognition · Computer Science 2023-09-28 Muhammad Abdullah Jamal , Omid Mohareri

This survey provides a comprehensive overview of recent advances in multimodal alignment and fusion within the field of machine learning, driven by the increasing availability and diversity of data modalities such as text, images, audio,…

Computer Vision and Pattern Recognition · Computer Science 2025-10-14 Songtao Li , Hao Tang

Multimodality Representation Learning, as a technique of learning to embed information from different modalities and their correlations, has achieved remarkable success on a variety of applications, such as Visual Question Answering (VQA),…

Artificial Intelligence · Computer Science 2024-03-04 Muhammad Arslan Manzoor , Sarah Albarri , Ziting Xian , Zaiqiao Meng , Preslav Nakov , Shangsong Liang

The Contrastive Language-Image Pre-training (CLIP) framework has become a widely used approach for multimodal representation learning, particularly in image-text retrieval and clustering. However, its efficacy is constrained by three key…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Tiancheng Gu , Kaicheng Yang , Ziyong Feng , Xingjun Wang , Yanzhao Zhang , Dingkun Long , Yingda Chen , Weidong Cai , Jiankang Deng

Artificial intelligence has demonstrated immense potential in scientific research. Within molecular science, it is revolutionizing the traditional computer-aided paradigm, ushering in a new era of deep learning. With recent progress in…

Biomolecules · Quantitative Biology 2024-03-22 Yi Xiao , Xiangxin Zhou , Qiang Liu , Liang Wang

Every molecule ever synthesised can be drawn as a 2D skeletal diagram, yet in modern property prediction this universally available representation has received less focus in favour of molecular graphs, 3D conformers, or billion-parameter…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Aaditya Baranwal , Akshaj Gupta , Shruti Vyas , Yogesh S Rawat

Multimodal learning from document data has achieved great success lately as it allows to pre-train semantically meaningful features as a prior into a learnable downstream task. In this paper, we approach the document classification problem…

Computer Vision and Pattern Recognition · Computer Science 2023-05-12 Souhail Bakkali , Zuheng Ming , Mickael Coustaty , Marçal Rusiñol , Oriol Ramos Terrades

Recent advancements in multi-modal pre-training for 3D point clouds have demonstrated promising results by aligning heterogeneous features across 3D shapes and their corresponding 2D images and language descriptions. However, current…

Computer Vision and Pattern Recognition · Computer Science 2024-09-19 Huiqun Wang , Yiping Bao , Panwang Pan , Zeming Li , Xiao Liu , Ruijie Yang , Di Huang