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Unsupervised estimation of the dimensionality of hyperspectral microspectroscopy datasets containing pure and mixed spectral features, and extraction of their representative endmember spectra, remains a challenge in biochemical data mining.…

We propose an unsupervised method using self-clustering convolutional adversarial autoencoders to classify prostate tissue as tumor or non-tumor without any labeled training data. The clustering method is integrated into the training of the…

Computer Vision and Pattern Recognition · Computer Science 2018-04-20 Wouter Bulten , Geert Litjens

Raman spectroscopy provides spectral information related to the specific molecular structures of substances and has been well established as a powerful tool for studying biological tissues and diagnosing diseases. This article reviews…

Recent advances in medical imaging techniques have led to significant improvements in the management of prostate cancer (PCa). In particular, multi-parametric MRI (mp-MRI) continues to gain clinical acceptance as the preferred imaging…

Image and Video Processing · Electrical Eng. & Systems 2019-10-08 Ruiming Cao , Xinran Zhong , Fabien Scalzo , Steven Raman , Kyung hyun Sung

Prostate cancer is one of the most prevalent cancers worldwide. One of the key factors in reducing its mortality is based on early detection. The computer-aided diagnosis systems for this task are based on the glandular structural analysis…

Image and Video Processing · Electrical Eng. & Systems 2021-05-25 Julio Silva-Rodríguez , Elena Payá-Bosch , Gabriel García , Adrián Colomer , Valery Naranjo

Radiologists often mix medical image reading strategies, including inspection of individual modalities and local image regions, using information at different locations from different images independently as well as concurrently. In this…

Computer Vision and Pattern Recognition · Computer Science 2026-01-09 Xiangcen Wu , Shaheer U. Saeed , Yipei Wang , Ester Bonmati Coll , Yipeng Hu

Cancer immunotherapy provides durable clinical benefit in only a small fraction of patients, particularly due to a lack of reliable biomarkers for accurate prediction of treatment outcomes and evaluation of response. Here, we demonstrate…

Cancer complexome comprises a heterogeneous and multifactorial milieu that varies in cytology, physiology, signaling mechanisms and response to therapy. The combined framework of network theory and spectral graph theory along with the…

Molecular Networks · Quantitative Biology 2017-03-03 Aparna Rai , Priodyuti Pradhan , Jyothi Nagraj , K. Lohitesh , Rajdeep Chowdhury , Sarika Jalan

Prostate cancer is a very common disease among adult men. One in seven Canadian men is diagnosed with this cancer in their lifetime. Super-Resolution (SR) can facilitate early diagnosis and potentially save many lives. In this paper, a…

Machine Learning · Computer Science 2021-05-21 Mahdiyar Molahasani Majdabadi , Younhee Choi , S. Deivalakshmi , Seokbum Ko

The concept of personalised medicine in cancer therapy is becoming increasingly important. There already exist drugs administered specifically for patients with tumours presenting well-defined mutations. However, the field is still in its…

Biomolecules · Quantitative Biology 2024-08-26 Abbi Abdel-Rehim , Oghenejokpeme Orhobor , Gareth Griffiths , Larisa Soldatova , Ross D. King

Prostate cancer is the most common cancer among US men. However, prostate imaging is still challenging despite the advances in multi-parametric Magnetic Resonance Imaging (MRI), which provides both morphologic and functional information…

Deep learning; it is often used in dividing processes on images in the biomedical field. In recent years, it has been observed that there is an increase in the division procedures performed on prostate images using deep learning compared to…

Image and Video Processing · Electrical Eng. & Systems 2021-11-23 Elcin Huseyn , Emin Mammadov , Mohammad Hoseini

Prostate cancer is a leading cause of cancer-related deaths among men. The recent development of high frequency, micro-ultrasound imaging offers improved resolution compared to conventional ultrasound and potentially a better ability to…

Pump-probe microscopy of melanin in tumors has been proposed to improve diagnosis of malignant melanoma, based on the hypothesis that aggressive cancers disaggregate melanin structure. However, measured signals of melanin are complex…

Deep neural networks are starting to show their worth in critical applications such as assisted cancer diagnosis. However, for their outputs to get accepted in practice, the results they provide should be explainable in a way easily…

Computer Vision and Pattern Recognition · Computer Science 2025-12-22 Martin Krebs , Jan Obdržálek , Vít Musil , Tomáš Brázdil

Automatic segmentation of the prostate cancer from the multi-modal magnetic resonance images is of critical importance for the initial staging and prognosis of patients. However, how to use the multi-modal image features more efficiently is…

Image and Video Processing · Electrical Eng. & Systems 2020-11-10 Guokai Zhang , Xiaoang Shen , Ye Luo , Jihao Luo , Zeju Wang , Weigang Wang , Binghui Zhao , Jianwei Lu

Active surveillance (AS) is a suitable management option for newly-diagnosed prostate cancer (PCa), which usually presents low to intermediate clinical risk. Patients enrolled in AS have their tumor closely monitored via longitudinal…

As the past decade barely dawned, a fundamentally novel view of cancer relating to signal transduction through intracellular hormones/growth factors and their subunits began to unfold. Further along, it gained additional substance with the…

Subcellular Processes · Quantitative Biology 2007-12-19 Razvan Tudor Radulescu

In previous theoretical research, we inferred that cancer stem cells (CSCs), the cells that presumably drive tumor growth and resistance to conventional cancer treatments, are not uniformly distributed in the bulk of a tumorsphere. To…

Quantitative Methods · Quantitative Biology 2024-03-06 Jerónimo Fotinós , María Paula Marks , Lucas Barberis , Luciano Vellón

Prostate cancer (PCa) poses a significant threat to men's health, with early diagnosis being crucial for improving prognosis and reducing mortality rates. Transrectal ultrasound (TRUS) plays a vital role in the diagnosis and image-guided…

Image and Video Processing · Electrical Eng. & Systems 2024-10-08 Haiqiao Wang , Hong Wu , Zhuoyuan Wang , Peiyan Yue , Dong Ni , Pheng-Ann Heng , Yi Wang