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Accurate diagnosis of pediatric brain tumors, starting with histopathology, presents unique challenges for deep learning, including severe data scarcity, class imbalance, and fine-grained morphologic overlap across diagnostically distinct…

Computer Vision and Pattern Recognition · Computer Science 2026-05-21 Joakim Nguyen , Jian Yu , Jinrui Fang , Nicholas Konz , Tianlong Chen , Sanjay Krishnan , Chandra Krishnan , Ying Ding , Hairong Wang , Ankita Shukla

Slide-level classification for whole-slide images (WSIs) has been widely recognized as a crucial problem in digital and computational pathology. Current approaches commonly consider WSIs as a bag of cropped patches and process them via…

Computer Vision and Pattern Recognition · Computer Science 2024-07-12 Doanh C. Bui , Trinh Thi Le Vuong , Jin Tae Kwak

The fine-grained annotations in whole slide images (WSIs) show the boundaries of various pathological regions. However, generating such detailed annotation is often costly, whereas the coarse annotations are relatively simpler to produce.…

Computer Vision and Pattern Recognition · Computer Science 2025-03-26 Bingjian Yao , Weiping Lin , Yan He , Zheng Wang , Liangsheng Wang

Multimodal graphs, where nodes contain heterogeneous features such as images and text, are increasingly common in real-world applications. Effectively learning on such graphs requires both adaptive intra-modal message passing and efficient…

Computer Vision and Pattern Recognition · Computer Science 2026-03-11 Xiaobin Hong , Mingkai Lin , Xiaoli Wang , Chaoqun Wang , Wenzhong Li

Finding an appropriate representation of dynamic activities in the brain is crucial for many downstream applications. Due to its highly dynamic nature, temporally averaged fMRI (functional magnetic resonance imaging) can only provide a…

Machine Learning · Computer Science 2022-08-18 Sikun Lin , Shuyun Tang , Scott Grafton , Ambuj Singh

Representation learning of pathology whole-slide images (WSIs) has been has primarily relied on weak supervision with Multiple Instance Learning (MIL). However, the slide representations resulting from this approach are highly tailored to…

Computer Vision and Pattern Recognition · Computer Science 2024-05-21 Andrew H. Song , Richard J. Chen , Tong Ding , Drew F. K. Williamson , Guillaume Jaume , Faisal Mahmood

Whole slide imaging (WSI) refers to the digitization of a tissue specimen which enables pathologists to explore high-resolution images on a monitor rather than through a microscope. The formation of tissue folds occur during tissue…

Image and Video Processing · Electrical Eng. & Systems 2019-03-19 Morteza Babaie , H. R. Tizhoosh

The segmentation and automatic identification of histological regions of diagnostic interest offer a valuable aid to pathologists. However, segmentation methods are hampered by the difficulty of obtaining pixel-level annotations, which are…

Image and Video Processing · Electrical Eng. & Systems 2023-02-02 Pushpak Pati , Guillaume Jaume , Zeineb Ayadi , Kevin Thandiackal , Behzad Bozorgtabar , Maria Gabrani , Orcun Goksel

Histomorphology is crucial in cancer diagnosis. However, existing whole slide image (WSI) classification methods struggle to effectively incorporate histomorphology information, limiting their ability to capture key pathological features.…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Baizhi Wang , Rui Yan , Wenxin Ma , Xu Zhang , Yuhao Wang , Xiaolong Li , Yunjie Gu , Zihang Jiang , S. Kevin Zhou

Deep learning has brought significant progress to medical image classification, yet most existing methods still rely on isolated visual evidence and cannot effectively leverage similar cases or external knowledge. In clinical practice,…

Computer Vision and Pattern Recognition · Computer Science 2026-05-28 Yiming Xu , Yixuan Liu , Yuhang Zhang , Ling Zheng , Yihan Wang , Qi Song

Fine-grained classification of whole slide images (WSIs) is essential in precision oncology, enabling precise cancer diagnosis and personalized treatment strategies. The core of this task involves distinguishing subtle morphological…

Computer Vision and Pattern Recognition · Computer Science 2025-04-07 Cheng Jin , Luyang Luo , Huangjing Lin , Jun Hou , Hao Chen

Dynamic scene understanding is the ability of a computer system to interpret and make sense of the visual information present in a video of a real-world scene. In this thesis, we present a series of frameworks for dynamic scene…

Computer Vision and Pattern Recognition · Computer Science 2023-12-14 Salman Khan

Whole slide image (WSI) classification is a critical task in computational pathology. However, the gigapixel-size of such images remains a major challenge for the current state of deep-learning. Current methods rely on multiple-instance…

Computer Vision and Pattern Recognition · Computer Science 2023-10-04 Etienne Pochet , Rami Maroun , Roger Trullo

Survival prediction, utilizing pathological images and genomic profiles, is increasingly important in cancer analysis and prognosis. Despite significant progress, precise survival analysis still faces two main challenges: (1) The massive…

Image and Video Processing · Electrical Eng. & Systems 2024-06-26 Songhan Jiang , Zhengyu Gan , Linghan Cai , Yifeng Wang , Yongbing Zhang

Multiple instance learning (MIL) is a key algorithm for classification of whole slide images (WSI). Histology WSIs can have billions of pixels, which create enormous computational and annotation challenges. Typically, such images are…

Image and Video Processing · Electrical Eng. & Systems 2021-11-03 Andriy Myronenko , Ziyue Xu , Dong Yang , Holger Roth , Daguang Xu

Histopathology image analysis can be considered as a Multiple instance learning (MIL) problem, where the whole slide histopathology image (WSI) is regarded as a bag of instances (i.e, patches) and the task is to predict a single class label…

Computer Vision and Pattern Recognition · Computer Science 2019-06-28 Meng Li , Lin Wu , Arnold Wiliem , Kun Zhao , Teng Zhang , Brian C. Lovell

Learning the manifold structure of remote sensing images is of paramount relevance for modeling and understanding processes, as well as to encapsulate the high dimensionality in a reduced set of informative features for subsequent…

Computer Vision and Pattern Recognition · Computer Science 2022-05-04 Gulsen Taskin , Gustau Camps-Valls

High-throughput "pathomic" analysis of Whole Slide Images (WSIs) offers new opportunities to study tissue characteristics and for biomarker discovery. However, the clinical relevance of the tissue characteristics at the micro- and…

Computer Vision and Pattern Recognition · Computer Science 2025-12-24 Yuechen Yang , Junlin Guo , Yanfan Zhu , Jialin Yue , Junchao Zhu , Yu Wang , Shilin Zhao , Haichun Yang , Xingyi Guo , Jovan Tanevski , Laura Barisoni , Avi Z. Rosenberg , Yuankai Huo

In pathology, whole-slide images (WSI) based survival prediction has attracted increasing interest. However, given the large size of WSIs and the lack of pathologist annotations, extracting the prognostic information from WSIs remains a…

Image and Video Processing · Electrical Eng. & Systems 2021-10-25 Shuai Jiang , Arief A. Suriawinata , Saeed Hassanpour

Many real-world data can be represented as heterogeneous graphs with different types of nodes and connections. Heterogeneous graph neural network model aims to embed nodes or subgraphs into low-dimensional vector space for various…

Artificial Intelligence · Computer Science 2024-12-24 Xinjun Cai , Jiaxing Shang , Fei Hao , Dajiang Liu , Linjiang Zheng