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Medical multimodal learning faces significant challenges with missing modalities prevalent in clinical practice. Existing approaches assume equal contribution of modality and random missing patterns, neglecting inherent uncertainty in…

Machine Learning · Computer Science 2026-01-30 Linxiao Gong , Yang Liu , Lianlong Sun , Yulai Bi , Jing Liu , Xiaoguang Zhu

Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss, making effective prognosis crucial for timely intervention. In this work, we propose AMD-Mamba, a novel multi-modal framework for AMD prognosis, and…

Image and Video Processing · Electrical Eng. & Systems 2025-08-06 Puzhen Wu , Mingquan Lin , Qingyu Chen , Emily Y. Chew , Zhiyong Lu , Yifan Peng , Hexin Dong

Purpose: To develop an open-source nnU-Net-based AI model for combined detection and segmentation of unruptured intracranial aneurysms (UICA) in 3D TOF-MRI, and compare models trained on datasets with aneurysm-like differential diagnoses.…

Computer Vision and Pattern Recognition · Computer Science 2024-09-02 Ashraya K. Indrakanti , Jakob Wasserthal , Martin Segeroth , Shan Yang , Victor Schulze-Zachau , Joshy Cyriac , Michael Bach , Marios Psychogios , Matthias A. Mutke

Objective: Acute intracranial hypertension is an important risk factor of secondary brain damage after traumatic brain injury. Hypertensive episodes are often diagnosed reactively, leading to late detection and lost time for intervention…

Signal Processing · Electrical Eng. & Systems 2020-12-03 Matthias Hüser , Adrian Kündig , Walter Karlen , Valeria De Luca , Martin Jaggi

Lesion detection in brain Magnetic Resonance Images (MRIs) remains a challenging task. MRIs are typically read and interpreted by domain experts, which is a tedious and time-consuming process. Recently, unsupervised anomaly detection (UAD)…

Image and Video Processing · Electrical Eng. & Systems 2022-02-01 Marcel Bengs , Finn Behrendt , Max-Heinrich Laves , Julia Krüger , Roland Opfer , Alexander Schlaefer

The United States is experiencing an opioid epidemic, and there were more than 10 million opioid misusers aged 12 or older each year. Identifying patients at high risk of Opioid Use Disorder (OUD) can help to make early clinical…

Healthcare facility visit prediction is essential for optimizing healthcare resource allocation and informing public health policy. Despite advanced machine learning methods being employed for better prediction performance, existing works…

Machine Learning · Computer Science 2026-05-22 Dahai Yu , Lin Jiang , Rongchao Xu , Guang Wang

Occupancy prediction has attracted intensive attention and shown great superiority in the development of autonomous driving systems. The fine-grained environmental representation brought by occupancy prediction in terms of both geometry and…

Computer Vision and Pattern Recognition · Computer Science 2024-08-22 Yonglin Tian , Songlin Bai , Zhiyao Luo , Yutong Wang , Yisheng Lv , Fei-Yue Wang

Alzheimer's disease (AD) is a chronic neurodegenerative condition responsible for most cases of dementia and considered as one of the greatest challenges for neuroscience in this century. Early Ad signs are usually mistaken for normal…

Neurons and Cognition · Quantitative Biology 2021-02-08 Juan A. Arias , Carmen Cadarso-Suárez , Pablo Aguiar-Fernández

In our research, we attempt to help people recognize their brain state of concentration or relaxation more conveniently and in real time. Considering the inconvenience of wearing traditional multiple electrode electroencephalographs, we…

Human-Computer Interaction · Computer Science 2015-09-28 Zhen Li , Jianjun Xu , Tingshao Zhu

Alzheimer's disease (AD) is a progressive neurodegenerative disease with high inter-patient variance in rate of cognitive decline. AD progression prediction aims to forecast patient cognitive decline and benefits from incorporating multiple…

Machine Learning · Computer Science 2025-09-17 Benjamin Burns , Yuan Xue , Douglas W. Scharre , Xia Ning

Alzheimer's disease (AD), defined as an abnormal buildup of amyloid plaques and tau tangles in the brain can be diagnosed with high accuracy based on protein biomarkers via PET or CSF analysis. However, due to the invasive nature of…

Machine Learning · Computer Science 2026-01-27 Megan A. Witherow , Michael L. Evans , Ahmed Temtam , Hamid R. Okhravi , Khan M. Iftekharuddin

Identifying epileptic seizures through analysis of the electroencephalography (EEG) signal becomes a standard method for the diagnosis of epilepsy. Manual seizure identification on EEG by trained neurologists is time-consuming,…

Machine Learning · Computer Science 2019-06-07 X. Yao , X. Li , Q. Ye , Y. Huang , Q. Cheng , G. -Q. Zhang

Accurate and interpretable mortality risk prediction in intensive care units (ICUs) remains a critical challenge due to the irregular temporal structure of electronic health records (EHRs), the complexity of longitudinal disease…

Machine Learning · Computer Science 2026-03-10 Zahra Jafari , Azadeh Zamanifar , Amirfarhad Farhadi

Accurate early prediction of in-hospital mortality in intensive care units (ICUs) is essential for timely clinical intervention and efficient resource allocation. This study develops and evaluates machine learning models that integrate both…

Machine Learning · Computer Science 2025-10-22 Nursultan Mamatov , Philipp Kellmeyer

Early clinical assessment of Alzheimer's disease relies on behavior scores that measure a subject's language, memory, and cognitive skills. On the medical imaging side, functional magnetic resonance imaging has provided invaluable insights…

Signal Processing · Electrical Eng. & Systems 2026-04-14 Javier Salazar Cavazos , Maximillian Egan , Krisanne Litinas , Benjamin Hampstead , Scott Peltier

The human brain is a complex and highly dynamic system, and our current knowledge of its functional mechanism is still very limited. Fortunately, with functional magnetic resonance imaging (fMRI), we can observe blood oxygen level-dependent…

Neurons and Cognition · Quantitative Biology 2024-12-31 Yifei Sun , Mariano Cabezas , Jiah Lee , Chenyu Wang , Wei Zhang , Fernando Calamante , Jinglei Lv

Depression is increasingly impacting individuals both physically and psychologically worldwide. It has become a global major public health problem and attracts attention from various research fields. Traditionally, the diagnosis of…

Human-Computer Interaction · Computer Science 2022-02-28 Kaining Mao , Wei Zhang , Deborah Baofeng Wang , Ang Li , Rongqi Jiao , Yanhui Zhu , Bin Wu , Tiansheng Zheng , Lei Qian , Wei Lyu , Minjie Ye , Jie Chen

Computer-aided methods have shown added value for diagnosing and predicting brain disorders and can thus support decision making in clinical care and treatment planning. This chapter will provide insight into the type of methods, their…

Existing Intensive Care Unit (ICU) delirium prediction models do not consider environmental factors despite strong evidence of their influence on delirium. This study reports the first deep-learning based delirium prediction model for ICU…