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In this paper, a contrastive evaluation of massively parallel implementations of suffix tree and suffix array to accelerate genome sequence matching are proposed based on Intel Core i7 3770K quad-core and NVIDIA GeForce GTX680 GPU. Besides…

Data Structures and Algorithms · Computer Science 2015-05-05 Gang Liao , Qi Sun , Longfei Ma , Sha Ding , Wen Xie

Alternating gradient-descent-ascent (AltGDA) is an optimization algorithm that has been widely used for model training in various machine learning applications, which aims to solve a nonconvex minimax optimization problem. However, the…

Machine Learning · Computer Science 2022-05-23 Ziyi Chen , Shaocong Ma , Yi Zhou

Various methods have been developed to analyze the association between organisms and their genomic sequences. Among them, sequence alignment is the most frequently used for comparative analysis of biological genomes. However, the…

Quantitative Methods · Quantitative Biology 2020-10-27 Yong Joon Song , Dong Jin Ji , Hye In Seo , Gyu Bum Han , Dong Ho Cho

Darwin is a genomics co-processor that achieved a 15000x acceleration on long read assembly through innovative hardware and algorithm co-design. Darwins algorithms and hardware implementation were specifically designed for DNA analysis…

Quantitative Methods · Quantitative Biology 2019-02-12 Sahand Kashani , Stuart Byma , James R. Larus

This paper presents the implementation of a quantum sequence alignment (QSA) algorithm on biological data in environments simulating noisy intermediate-scale quantum (NISQ) computers. The approach to quantum bioinformatics adapts the…

Quantum Physics · Physics 2025-07-02 Floyd M. Creevey , Mingrui Jing , Lloyd C. L. Hollenberg

Reference-guided DNA sequencing and alignment is an important process in computational molecular biology. The amount of DNA data grows very fast, and many new genomes are waiting to be sequenced while millions of private genomes need to be…

In genomics, pattern matching against a sequence of nucleotides plays a pivotal role for DNA sequence alignment and comparing genomes. This helps tackling some diseases, such as cancer in humans. The complexity of searching biological…

Quantitative Methods · Quantitative Biology 2017-10-04 Fereshte Mozafari , Hossein Babashah , Somayyeh Koohi , Zahra Kavehvash

Non-orthogonal multiple access (NOMA) is an interesting technology that enables massive connectivity as required in future 5G and 6G networks. While purely linear processing already achieves good performance in NOMA systems, in certain…

Signal Processing · Electrical Eng. & Systems 2022-06-14 Daniel Schäufele , Guillermo Marcus , Nikolaus Binder , Matthias Mehlhose , Alexander Keller , Sławomir Stańczak

Typically, Ultra-deep neural network(UDNN) tends to yield high-quality model, but its training process is usually resource intensive and time-consuming. Modern GPU's scarce DRAM capacity is the primary bottleneck that hinders the…

Machine Learning · Computer Science 2019-06-21 Jinrong Guo , Wantao Liu , Wang Wang , Qu Lu , Songlin Hu , Jizhong Han , Ruixuan Li

Many mission-critical systems are based on GPU for inference. It requires not only high recognition accuracy but also low latency in responding time. Although many studies are devoted to optimizing the structure of deep models for efficient…

Computer Vision and Pattern Recognition · Computer Science 2020-08-13 Ming Lin , Hesen Chen , Xiuyu Sun , Qi Qian , Hao Li , Rong Jin

We describe the GPU implementation of shifted or multimass iterative solvers for sparse linear systems of the sort encountered in lattice gauge theory. We provide a generic tool that can be used by those without GPU programming experience…

High Energy Physics - Lattice · Physics 2011-02-16 Richard Galvez , Greg van Anders

Stochastic optimization plays a crucial role in the advancement of deep learning technologies. Over the decades, significant effort has been dedicated to improving the training efficiency and robustness of deep neural networks, via various…

Machine Learning · Computer Science 2024-08-21 Huixiu Jiang , Ling Yang , Yu Bao , Rutong Si , Sikun Yang

Modern transformer-based deep neural networks present unique technical challenges for effective acceleration in real-world applications. Apart from the vast amount of linear operations needed due to their sizes, modern transformer models…

Hardware Architecture · Computer Science 2024-11-07 Jiajun Wu , Mo Song , Jingmin Zhao , Yizhao Gao , Jia Li , Hayden Kwok-Hay So

Molecular similarity search has been widely used in drug discovery to identify structurally similar compounds from large molecular databases rapidly. With the increasing size of chemical libraries, there is growing interest in the efficient…

Hardware Architecture · Computer Science 2021-09-15 Hongwu Peng , Shiyang Chen , Zhepeng Wang , Junhuan Yang , Scott A. Weitze , Tong Geng , Ang Li , Jinbo Bi , Minghu Song , Weiwen Jiang , Hang Liu , Caiwen Ding

The efficiency of long-video inference remains a critical bottleneck, mainly due to the dense computation in the prefill stage of Large Multimodal Models (LMMs). Existing methods either compress visual embeddings or apply sparse attention…

Computer Vision and Pattern Recognition · Computer Science 2026-01-30 Yuxiang Huang , Mingye Li , Xu Han , Chaojun Xiao , Weilin Zhao , Ao Sun , Ziqi Yuan , Hao Zhou , Fandong Meng , Zhiyuan Liu

We present a new algorithm to quickly generate high-performance GPU implementations of complex imaging and vision pipelines, directly from high-level Halide algorithm code. It is fully automatic, requiring no schedule templates or…

Programming Languages · Computer Science 2023-08-29 Luke Anderson , Andrew Adams , Karima Ma , Tzu-Mao Li , Tian Jin , Jonathan Ragan-Kelley

Summary: Longer sequencing reads, with at least 200 bases per template are now common. While traditional aligners have adopted new strategies to improve the mapping of longer reads, aligners specific to bisulfite-sequencing were optimized…

Genomics · Quantitative Biology 2014-05-14 Brent S. Pedersen , Kenneth Eyring , Subhajyoti De , Ivana V. Yang , David A. Schwartz

Many modern machine learning algorithms such as generative adversarial networks (GANs) and adversarial training can be formulated as minimax optimization. Gradient descent ascent (GDA) is the most commonly used algorithm due to its…

Machine Learning · Computer Science 2022-07-01 Huan He , Shifan Zhao , Yuanzhe Xi , Joyce C Ho , Yousef Saad

In the paper, we propose a class of faster adaptive Gradient Descent Ascent (GDA) methods for solving the nonconvex-strongly-concave minimax problems by using the unified adaptive matrices, which include almost all existing coordinate-wise…

Optimization and Control · Mathematics 2023-02-22 Feihu Huang , Xidong Wu , Zhengmian Hu

Motivation: Recent advances in sequencing technologies promise ultra-long reads of $\sim$100 kilo bases (kb) in average, full-length mRNA or cDNA reads in high throughput and genomic contigs over 100 mega bases (Mb) in length. Existing…

Genomics · Quantitative Biology 2018-09-17 Heng Li