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Recent success in training deep neural networks have prompted active investigation into the features learned on their intermediate layers. Such research is difficult because it requires making sense of non-linear computations performed by…

Machine Learning · Computer Science 2016-03-01 Yixuan Li , Jason Yosinski , Jeff Clune , Hod Lipson , John Hopcroft

The capability of accurate prediction of protein functions and properties is essential in the biotechnology industry, e.g. drug development and artificial protein synthesis, etc. The main challenges of protein function prediction are the…

Quantitative Methods · Quantitative Biology 2021-12-02 Wei-Cheng Tseng , Po-Han Chi , Jia-Hua Wu , Min Sun

Proteins, essential to biological systems, perform functions intricately linked to their three-dimensional structures. Understanding the relationship between protein structures and their amino acid sequences remains a core challenge in…

Quantitative Methods · Quantitative Biology 2024-11-04 Liang He , Peiran Jin , Yaosen Min , Shufang Xie , Lijun Wu , Tao Qin , Xiaozhuan Liang , Kaiyuan Gao , Yuliang Jiang , Tie-Yan Liu

Computational protein design has a wide variety of applications. Despite its remarkable success, designing a protein for a given structure and function is still a challenging task. On the other hand, the number of solved protein structures…

Quantitative Methods · Quantitative Biology 2018-04-26 Jingxue Wang , Huali Cao , John Z. H. Zhang , Yifei Qi

Deep learning in medical imaging is often limited by scarce and imbalanced annotated data. We present SSGNet, a unified framework that combines class specific generative modeling with iterative semisupervised pseudo labeling to enhance both…

Computer Vision and Pattern Recognition · Computer Science 2025-10-08 Mosong Ma , Tania Stathaki , Michalis Lazarou

Graph convolutional networks (GCNs) allow us to learn topologically-aware node embeddings, which can be useful for classification or link prediction. However, they are unable to capture long-range dependencies between nodes without adding…

Machine Learning · Computer Science 2023-08-17 Reza Namazi , Elahe Ghalebi , Sinead Williamson , Hamidreza Mahyar

Deep Operator Network (DeepONet), a recently introduced deep learning operator network, approximates linear and nonlinear solution operators by taking parametric functions (infinite-dimensional objects) as inputs and mapping them to…

Computational Engineering, Finance, and Science · Computer Science 2023-10-12 Junyan He , Shashank Kushwaha , Jaewan Park , Seid Koric , Diab Abueidda , Iwona Jasiuk

Deep learning has received much attention lately due to the impressive empirical performance achieved by training algorithms. Consequently, a need for a better theoretical understanding of these problems has become more evident in recent…

Machine Learning · Computer Science 2022-03-03 Daniel Bienstock , Gonzalo Muñoz , Sebastian Pokutta

Detecting the occlusion from stereo images or video frames is important to many computer vision applications. Previous efforts focus on bundling it with the computation of disparity or optical flow, leading to a chicken-and-egg problem. In…

Computer Vision and Pattern Recognition · Computer Science 2018-09-25 Ang Li , Zejian Yuan

Establishing robust and accurate correspondences is a fundamental backbone to many computer vision algorithms. While recent learning-based feature matching methods have shown promising results in providing robust correspondences under…

Computer Vision and Pattern Recognition · Computer Science 2020-04-06 Hugo Germain , Guillaume Bourmaud , Vincent Lepetit

Remarkable achievements have been attained by deep neural networks in various applications. However, the increasing depth and width of such models also lead to explosive growth in both storage and computation, which has restricted the…

Machine Learning · Computer Science 2019-06-11 Linfeng Zhang , Zhanhong Tan , Jiebo Song , Jingwei Chen , Chenglong Bao , Kaisheng Ma

Protein representation learning (PRL) is crucial for understanding structure-function relationships, yet current sequence- and graph-based methods fail to capture the hierarchical organization inherent in protein structures. We introduce…

Machine Learning · Computer Science 2025-09-05 Zhiyu Wang , Arian Jamasb , Mustafa Hajij , Alex Morehead , Luke Braithwaite , Pietro Liò

Deep learning empowers the mainstream medical image segmentation methods. Nevertheless current deep segmentation approaches are not capable of efficiently and effectively adapting and updating the trained models when new incremental…

Computer Vision and Pattern Recognition · Computer Science 2023-09-06 Zhanghexuan Ji , Dazhou Guo , Puyang Wang , Ke Yan , Le Lu , Minfeng Xu , Jingren Zhou , Qifeng Wang , Jia Ge , Mingchen Gao , Xianghua Ye , Dakai Jin

Computational drug discovery provides an efficient tool helping large scale lead molecules screening. One of the major tasks of lead discovery is identifying molecules with promising binding affinities towards a target, a protein in…

Biological Physics · Physics 2019-09-18 Liangzhen Zheng , Jingrong Fan , Yuguang Mu

Recent advances in end-to-end unsupervised learning has significantly improved the performance of monocular depth prediction and alleviated the requirement of ground truth depth. Although a plethora of work has been done in enforcing…

Computer Vision and Pattern Recognition · Computer Science 2020-05-19 Vinay Kaushik , Brejesh Lall

We consider Convolutional Neural Networks (CNNs) with 2D structured features that are symmetric in the spatial dimensions. Such networks arise in modeling pairwise relationships for a sequential recommendation problem, as well as secondary…

Machine Learning · Statistics 2022-03-07 Kehelwala Dewage Gayan Maduranga , Vasily Zadorozhnyy , Qiang Ye

Data-efficient image classification is a challenging task that aims to solve image classification using small training data. Neural network-based deep learning methods are effective for image classification, but they typically require…

Neural and Evolutionary Computing · Computer Science 2022-12-05 Ying Bi , Bing Xue , Mengjie Zhang

Recognizing symmetries in data allows for significant boosts in neural network training. In many cases, however, the underlying symmetry is present only in an idealized dataset, and is broken in the training data, due to effects such as…

High Energy Physics - Experiment · Physics 2023-11-13 Edmund Witkowski , Daniel Whiteson

As the electromagnetic environment becomes increasingly complex, Global Navigation Satellite Systems (GNSS) face growing threats from sophisticated jamming interference. Although Deep Learning (DL) effectively identifies basic interference,…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Zhihan Zeng , Yang Zhao , Kaihe Wang , Dusit Niyato , Hongyuan Shu , Junchu Zhao , Yanjun Huang , Yue Xiu , Zhongpei Zhang , Ning Wei

Segmentation of Prostate Cancer (PCa) tissues from Gleason graded histopathology images is vital for accurate diagnosis. Although deep learning (DL) based segmentation methods achieve state-of-the-art accuracy, they rely on large datasets…

Image and Video Processing · Electrical Eng. & Systems 2021-10-04 Dwarikanath Mahapatra