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We propose a novel probabilistic dimensionality reduction framework that can naturally integrate the generative model and the locality information of data. Based on this framework, we present a new model, which is able to learn a smooth…

Machine Learning · Statistics 2016-10-18 Li Wang

In modern applications such as ECG monitoring, neuroimaging, wearable sensing, and industrial equipment diagnostics, complex and continuously structured data are ubiquitous, presenting both challenges and opportunities for functional data…

Machine Learning · Computer Science 2026-03-03 Xiaoxian Zhu , Yingmeng Li , Shuangge Ma , Mengyun Wu

Deep learning has revolutionized many industries by enabling models to automatically learn complex patterns from raw data, reducing dependence on manual feature engineering. However, deep learning algorithms are sensitive to input data, and…

Machine Learning · Computer Science 2025-07-21 Mert Sehri , Zehui Hua , Francisco de Assis Boldt , Patrick Dumond

Automatic classification of epileptic seizure types in electroencephalograms (EEGs) data can enable more precise diagnosis and efficient management of the disease. This task is challenging due to factors such as low signal-to-noise ratios,…

Machine Learning · Computer Science 2020-10-01 Umar Asif , Subhrajit Roy , Jianbin Tang , Stefan Harrer

Camouflaged object detection segments objects with intrinsic similarity and edge disruption. Current detection methods rely on accumulated complex components. Each approach adds components such as boundary modules, attention mechanisms, and…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Baber Jan , Saeed Anwar , Aiman H. El-Maleh , Abdul Jabbar Siddiqui , Abdul Bais

The development of single-cell and spatial transcriptomics has revolutionized our capacity to investigate cellular properties, functions, and interactions in both cellular and spatial contexts. However, the analysis of single-cell and…

Genomics · Quantitative Biology 2024-12-09 Shuang Ge , Shuqing Sun , Huan Xu , Qiang Cheng , Zhixiang Ren

Networks are ubiquitous structure that describes complex relationships between different entities in the real world. As a critical component of prediction task over nodes in networks, learning the feature representation of nodes has become…

Machine Learning · Computer Science 2018-09-10 Hansheng Xue , Jiajie Peng , Xuequn Shang

Symmetries (transformations by group actions) are present in many datasets, and leveraging them holds considerable promise for improving predictions in machine learning. In this work, we aim to understand when and how deep networks -- with…

Machine Learning · Computer Science 2025-06-27 Andrea Perin , Stephane Deny

The ability to computationally generate novel yet physically foldable protein structures could lead to new biological discoveries and new treatments targeting yet incurable diseases. Despite recent advances in protein structure prediction,…

Biomolecules · Quantitative Biology 2022-11-28 Kevin E. Wu , Kevin K. Yang , Rianne van den Berg , James Y. Zou , Alex X. Lu , Ava P. Amini

Deep learning models are gaining popularity and potency in predicting polymer properties. These models can be built using pre-existing data and are useful for the rapid prediction of polymer properties. However, the performance of a deep…

Materials Science · Physics 2022-10-14 Himanshu , Tarak K Patra

During the past decade, with the significant progress of computational power as well as ever-rising data availability, deep learning techniques became increasingly popular due to their excellent performance on computer vision problems. The…

Quantitative Methods · Quantitative Biology 2017-07-20 Afshine Amidi , Shervine Amidi , Dimitrios Vlachakis , Vasileios Megalooikonomou , Nikos Paragios , Evangelia I. Zacharaki

Deep neural networks have shown the ability to extract universal feature representations from data such as images and text that have been useful for a variety of learning tasks. However, the fruits of representation learning have yet to be…

Machine Learning · Computer Science 2023-03-28 Liam Collins , Hamed Hassani , Aryan Mokhtari , Sanjay Shakkottai

We propose a simplicial complex convolutional neural network (SCCNN) to learn data representations on simplicial complexes. It performs convolutions based on the multi-hop simplicial adjacencies via common faces and cofaces independently…

Machine Learning · Computer Science 2023-01-27 Maosheng Yang , Elvin Isufi

Protein structure prediction has been a grand challenge for over 50 years, owing to its broad scientific and application interests. There are two primary types of modeling algorithms, template-free modeling and template-based modeling. The…

Biological Physics · Physics 2021-06-01 Liangzhen Zheng , Haidong Lan , Tao Shen , Jiaxiang Wu , Sheng Wang , Wei Liu , Junzhou Huang

Deep metric learning applied to various applications has shown promising results in identification, retrieval and recognition. Existing methods often do not consider different granularity in visual similarity. However, in many domain…

Computer Vision and Pattern Recognition · Computer Science 2021-05-17 Dipu Manandhar , Muhammet Bastan , Kim-Hui Yap

Motivation: Understanding functions of proteins in specific human tissues is essential for insights into disease diagnostics and therapeutics, yet prediction of tissue-specific cellular function remains a critical challenge for biomedicine.…

Machine Learning · Computer Science 2017-07-18 Marinka Zitnik , Jure Leskovec

Current CNN-based infrared small target detection(IRSTD) methods generally overlook the heterogeneity between shallow and deep features, leading to inefficient collaboration between shallow fine grained structural information and deep…

Computer Vision and Pattern Recognition · Computer Science 2025-07-29 Taoran Yue , Xiaojin Lu , Jiaxi Cai , Yuanping Chen , Shibing Chu

How proteins fold remains a central unsolved problem in biology. While the idea of a folding code embedded in the amino acid sequence was introduced more than 6 decades ago, this code remains undefined. While we now have powerful predictive…

Biomolecules · Quantitative Biology 2025-11-04 Carlos Bustamante , Christian Kaiser , Erik Lindahl , Robert Sosa , Giovanni Volpe

Protein structure prediction remains a challenge in the field of computational biology. Traditional protein structure prediction approaches include template-based modelling (say, homology modelling, and threading), and ab initio. A…

Other Quantitative Biology · Quantitative Biology 2015-07-14 Jianwei Zhu , Haicang Zhang , Chao Wang , Bin Ling , Wei-Mou Zheng , Dongbo Bu

We present SkelNetOn 2019 Challenge and Deep Learning for Geometric Shape Understanding workshop to utilize existing and develop novel deep learning architectures for shape understanding. We observed that unlike traditional segmentation and…

Computer Vision and Pattern Recognition · Computer Science 2019-06-25 Ilke Demir , Camilla Hahn , Kathryn Leonard , Geraldine Morin , Dana Rahbani , Athina Panotopoulou , Amelie Fondevilla , Elena Balashova , Bastien Durix , Adam Kortylewski