Related papers: Action potentials in vitro: theory and experiment
The Artificial Axon is a unique synthetic system, based on biomolecular components, which supports action potentials. Here we examine, experimentally and theoretically, the properties of the threshold for firing in this system. As in real…
The artificial axon is an excitable node built with the basic biomolecular components and supporting action potentials. Here we demonstrate coincidence firing (the AND operation) and other basic electrophysiology features such as increasing…
Mathematical models for the generation of the action potential can improve the understanding of physiological mechanisms that are consequence of the electrical activity in neurons. In such models, some equations involving empirically…
We demonstrate that our recently developed theory of electric field wave propagation in anisotropic and inhomogeneous brain tissues, which has been shown to explain a broad range of observed coherent synchronous brain electrical processes,…
The Artificial Axon is a unique synthetic system, based on biomolecular components, which supports action potentials. Here we consider, theoretically, the corresponding space extended system, and discuss the occurrence of solitary waves, or…
The artificial axon is a recently introduced synthetic assembly of supported lipid bilayers and voltage gated ion channels, displaying the basic electrophysiology of nerve cells. Here we demonstrate the use of two artificial axons as…
In the context of multi-agent systems of binary interacting particles, a kinetic model for action potential dynamics on a neural network is proposed, accounting for heterogeneity in the neuron-to-neuron connections, as well as in the brain…
We suggest that the propagation of the action potential is driven by a pressure pulse propagating in the axoplasm along the axon length. The pressure pulse mechanically activates Na ion channels embedded in the axon membrane. This…
In this paper we present a computational modeling account of an active self in artificial agents. In particular we focus on how an agent can be equipped with a sense of control and how it arises in autonomous situated action and, in turn,…
Comprehending the nature of action potentials is fundamental to our understanding of the functioning of nervous systems in general. Here we consider their evolution and describe their functions of communication, modulation and computation…
The spontaneous generation of electrical activity underpins a number of essential physiological processes, and is observed even in tissues where specialized pacemaker cells have not been identified. The emergence of periodic oscillations in…
The result of computational operations performed at the single cell level are coded into sequences of action potentials (APs). In the cerebral cortex, due to its columnar organization, large number of neurons are involved in any individual…
We propose a neural network model of multi-neuron interacting system that simulates neurons to interact each other through the surroundings of neuronal cell bodies. We physically model the neuronal cell surroundings, include the dendrites,…
Central neurons initiate action potentials (APs) in the axon initial segment (AIS), a compartment characterized by a high concentration of voltage-dependent ion channels and specialized cytoskeletal anchoring proteins arranged in a regular…
We give a constructive method for realizing an arbitrary directed graph (with no one-cycles) as a heteroclinic or an excitable dynamic network in the phase space of a system of coupled cells of two types. In each case, the system is…
This study aims at finding a method for constructing molecular dynamics like models using the formalism of cellular automata for fast simulation of fluid dynamic systems (including compressible phenomena). In as much as the results…
Comprehending the nature of action potentials is fundamental to our understanding of the functioning of nervous systems in general. The ionic mechanisms underlying action potentials in the squid giant axon were first described by Hodgkin…
We consider a new class of interacting particle systems with a countable number of interacting components. The system represents the time evolution of the membrane potentials of an infinite set of interacting neurons. We prove the existence…
Genetically encoded regulatory circuits control biological function. A major focus of systems biology is to understand these circuits by establishing the relationship between specific structures and functions. Of special interest are…
In a succession of articles published over 65 years ago, Sir Alan Lloyd Hodgkin and Sir Andrew Fielding Huxley established what now forms our physical understanding of excitation in nerve, and how the axon conducts the action potential.…