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Rapidly developing machine learning methods has stimulated research interest in computationally reconstructing differential equations (DEs) from observational data which may provide additional insight into underlying causative mechanisms.…

Machine Learning · Computer Science 2026-05-12 Mingtao Xia , Xiangting Li , Qijing Shen , Tom Chou

Speckle is an intrinsic pattern in optical coherence tomography (OCT) that obscures fine image features and degrades effective resolution. In this study, we propose a numerical speckle reduction method based on the dispersed scatterer model…

A new formulation of lateral imaging process of point-scanning optical coherence tomography (OCT) and a new differential contrast method designed by using this formulation are presented. The formulation is based on a mathematical sample…

We propose a new modeling approach for scatter estimation and descattering in polyenergetic X-ray computed tomography (CT) based on fitting models to local neighborhoods of a training set. X-ray CT is widely used in medical and industrial…

Image and Video Processing · Electrical Eng. & Systems 2021-09-30 Michael T. McCann , Marc L. Klasky , Jennifer L. Schei , Saiprasad Ravishankar

Purpose: To develop a deep learning approach to digitally-stain optical coherence tomography (OCT) images of the optic nerve head (ONH). Methods: A horizontal B-scan was acquired through the center of the ONH using OCT (Spectralis) for 1…

In Optical Coherence Tomography (OCT), speckle noise significantly hampers image quality, affecting diagnostic accuracy. Current methods, including traditional filtering and deep learning techniques, have limitations in noise reduction and…

Image and Video Processing · Electrical Eng. & Systems 2024-02-27 Aytaç Özkan , Elena Stoykova , Thomas Sikora , Violeta Madjarova

Simulation-based ultrasound training can be an essential educational tool. Realistic ultrasound image appearance with typical speckle texture can be modeled as convolution of a point spread function with point scatterers representing tissue…

Computer Vision and Pattern Recognition · Computer Science 2020-06-19 Lin Zhang , Valery Vishnevskiy , Orcun Goksel

The distinction between malignant and benign tumors is essential to the treatment of cancer. The tissue's elasticity can be used as an indicator for the required tissue characterization. Optical coherence elastography (OCE) probes have been…

Image and Video Processing · Electrical Eng. & Systems 2021-09-21 Robin Mieling , Johanna Sprenger , Sarah Latus , Lennart Bargsten , Alexander Schlaefer

Noise in speckle-prone optical coherence tomography tends to obfuscate important details necessary for medical diagnosis. In this paper, a denoising approach that preserves disease characteristics on retinal optical coherence tomography…

Computer Vision and Pattern Recognition · Computer Science 2019-03-26 Max-Heinrich Laves , Sontje Ihler , Lüder Alexander Kahrs , Tobias Ortmaier

Optical Coherence Tomography (OCT) imaging is pivotal in diagnosing ophthalmic conditions by providing detailed cross-sectional images of the anterior and posterior segments of the eye. Nonetheless, speckle noise and other imaging artifacts…

Image and Video Processing · Electrical Eng. & Systems 2024-09-26 Akkidas Noel Prakash , Jahnvi Sai Ganta , Ramaswami Krishnadas , Tin A. Tunc , Satish K Panda

Inverse scattering in optical coherence tomography (OCT) seeks to recover both structural images and intrinsic tissue optical properties, including refractive index, scattering coefficient, and anisotropy. This inverse problem is…

Computer Vision and Pattern Recognition · Computer Science 2026-02-04 Jinglun Yu , Yaning Wang , Wenhan Guo , Yuan Gao , Yu Sun , Jin U. Kang

Optical Coherence Tomography (OCT) image denoising is a fundamental problem as OCT images suffer from multiplicative speckle noise, resulting in poor visibility of retinal layers. The traditional denoising methods consider specific…

Image and Video Processing · Electrical Eng. & Systems 2022-09-21 Arka Saha , Sourya Sengupta

Large-scale multimodal contrastive learning has recently achieved impressive success in learning rich and transferable representations, yet it remains fundamentally limited by the uniform treatment of feature dimensions and the neglect of…

Machine Learning · Computer Science 2026-02-11 Jinjin Guo , Yexin Li , Zhichao Huang , Jun Fang , Zhiyuan Liu , Chao Liu , Pengzhang Liu , Qixia Jiang

We identify effective stochastic differential equations (SDE) for coarse observables of fine-grained particle- or agent-based simulations; these SDE then provide useful coarse surrogate models of the fine scale dynamics. We approximate the…

Recent years have witnessed significant progress in developing effective training and fast sampling techniques for diffusion models. A remarkable advancement is the use of stochastic differential equations (SDEs) and their…

Computer Vision and Pattern Recognition · Computer Science 2024-08-26 Defang Chen , Zhenyu Zhou , Jian-Ping Mei , Chunhua Shen , Chun Chen , Can Wang

Optical Coherence Tomography (OCT) is a widely used non-invasive biomedical imaging modality that can rapidly provide volumetric images of samples. Here, we present a deep learning-based image reconstruction framework that can generate…

Image and Video Processing · Electrical Eng. & Systems 2021-07-30 Yijie Zhang , Tairan Liu , Manmohan Singh , Yilin Luo , Yair Rivenson , Kirill V. Larin , Aydogan Ozcan

Ordinary differential equation (ODE) is widely used in modeling biological and physical processes in science. In this article, we propose a new reproducing kernel-based approach for estimation and inference of ODE given noisy observations.…

Methodology · Statistics 2021-10-26 Xiaowu Dai , Lexin Li

Holographic optical coherence tomography (OCT) is a powerful imaging technique, but its ability to reveal low-reflectivity features is limited. In this study, we performed holographic OCT by incoherently averaging volumes with changing…

Scattering medium brings great difficulties to locate and image planar objects especially when the object has a large depth. In this letter, a novel learning-based method is presented to locate and image the object hidden behind a thin…

Image and Video Processing · Electrical Eng. & Systems 2020-06-01 Shuo Zhu , Enlai Guo , Qianying Cui , Dongliang Zheng , Lianfa Bai , Jing Han

Recently, spectral CT has been drawing a lot of attention in a variety of clinical applications primarily due to its capability of providing quantitative information about material properties. The quantitative integrity of the reconstructed…

Medical Physics · Physics 2018-01-12 Shiyu Xu , Peter Prinsen , Jens Wiegert , Ravindra Manjeshwar
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