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The complexity of mathematical models describing respiratory mechanics has grown in recent years to integrate with cardiovascular models and incorporate nonlinear dynamics. However, additional model complexity has rarely been studied in the…

Tissues and Organs · Quantitative Biology 2020-01-17 Laura Ellwein Fix

Non-invasive estimation of respiratory physiology using computational algorithms promises to be a valuable technique for future clinicians to detect detrimental changes in patient pathophysiology. However, few clinical algorithms used to…

Quantitative Methods · Quantitative Biology 2021-09-22 Gregory Rehm , Jimmy Nguyen , Chelsea Gilbeau , Marc T Bomactao , Chen-Nee Chuah , Jason Adams

The complexity of mathematical models describing respiratory mechanics has grown in recent years, however, parameter identifiability of such models has only been studied in the last decade in the context of observable data. This study…

Tissues and Organs · Quantitative Biology 2025-01-16 Richard R. Foster , Laura Ellwein Fix

This study performs parameter inference in a partial differential equations system of pulmonary circulation. We use a fluid dynamics network model that takes selected parameter values and mimics the behaviour of the pulmonary haemodynamics…

In this paper we present a method for the estimation of leaks in non-invasive ventilation. Accurate estimation of leaks is a key component of a ventilator, since it determines the ventilator performance in terms of patient-ventilator…

Medical Physics · Physics 2021-08-19 Francesco Vicario , Samiya Alkhairy , Roberto Buizza , William A. Truschel

We present a new approach for physics-based computational modeling of diseased human lungs. Our main object is the development of a model that takes the novel step of incorporating the dynamics of airway recruitment/de-recruitment into an…

Computational Engineering, Finance, and Science · Computer Science 2023-05-10 Carolin M. Geitner , Tobias Becher , Inéz Frerichs , Norbert Weiler , Jason H. T. Bates , Wolfgang A. Wall

Respiratory diseases impose a significant burden on global health, with current diagnostic and management practices primarily reliant on specialist clinical testing. This work aims to develop machine learning-based algorithms to facilitate…

Machine Learning · Computer Science 2024-09-06 Negar Orangi-Fard , Alexandru Bogdan , Hersh Sagreiya

The choice of lung protective ventilation settings for mechanical ventilation has a considerable impact on patient outcome, yet identifying optimal ventilatory settings for individual patients remains highly challenging due to the inherent…

An efficient technique is introduced for model inference of complex nonlinear dynamical systems driven by noise. The technique does not require extensive global optimization, provides optimal compensation for noise-induced errors and is…

Data Analysis, Statistics and Probability · Physics 2007-05-23 V. N. Smelyanskiy , D. A. Timucin , A. Bandrivskyy , D. G. Luchinsky

We introduce a novel algorithm for online estimation of acoustic impulse responses (AIRs) which allows for fast convergence by exploiting prior knowledge about the fundamental structure of AIRs. The proposed method assumes that the…

Audio and Speech Processing · Electrical Eng. & Systems 2021-05-10 Thomas Haubner , Andreas Brendel , Walter Kellermann

This work presents a nonlinear system identification framework for modeling the power extraction dynamics of wind turbines, including both freestream and waked conditions. The approach models turbine dynamics using data-driven power…

Systems and Control · Electrical Eng. & Systems 2025-10-10 Sebastiano Randino , Lorenzo Schena , Nicolas Coudou , Emanuele Garone , Miguel Alfonso Mendez

Nonlinear dynamic models are widely used for characterizing functional forms of processes that govern complex biological pathway systems. Over the past decade, validation and further development of these models became possible due to data…

Methodology · Statistics 2019-08-13 Itai Dattner , Shota Gugushvili , Harold Ship , Eberhard O. Voit

This paper presents a recurrent neural network approach to simulating mechanical ventilator pressure. The traditional mechanical ventilator has a control pressure that is monitored by a medical practitioner and can behave incorrectly if the…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-10-10 Su Diao , Changsong Wei , Junyu Wang , Yizhou Li

The purpose of this study is to provide means to physicians for automated and fast recognition of airways diseases. In this work, we mainly focus on measures that can be easily recorded using a spirometer. The signals used in this framework…

Machine Learning · Computer Science 2021-11-09 Riccardo Dio , André Galligo , Angelos Mantzaflaris , Benjamin Mauroy

This study uses a one dimensional fluid dynamics arterial network model to infer changes in hemodynamic quantities associated with pulmonary hypertension in mice. Data for this study include blood flow and pressure measurements from the…

Machine learning is becoming increasingly important for nonlinear system identification, including dynamical systems with spatially distributed outputs. However, classical identification and forecasting approaches become markedly less…

Systems and Control · Electrical Eng. & Systems 2026-04-21 Achraf El Messaoudi , Noureddine Khaous , Karim Cherifi

Mathematical models and numerical simulations offer a non-invasive way to explore cardiovascular phenomena, providing access to quantities that cannot be measured directly. In this study, we start with a one-dimensional multiscale blood…

Machine Learning · Computer Science 2026-04-09 Giulia Bertaglia , Raffaella Fiamma Cabini

Non-invasive ventilation is increasingly used for respiratory support in preterm infants, and is associated with a lower risk of chronic lung disease. However, this mode is often not successful in the extremely preterm infant in part due to…

Tissues and Organs · Quantitative Biology 2018-07-04 Laura Ellwein Fix , Joseph Khoury , Russell Moores , Lauren Linkous , Matthew Brandes , Henry J. Rozycki

We applied deep learning to create an algorithm for breathing phase detection in lung sound recordings, and we compared the breathing phases detected by the algorithm and manually annotated by two experienced lung sound researchers. Our…

Computer Vision and Pattern Recognition · Computer Science 2019-04-18 Cristina Jácome , Johan Ravn , Einar Holsbø , Juan Carlos Aviles-Solis , Hasse Melbye , Lars Ailo Bongo

Online system identification algorithms are widely used for monitoring, diagnostics and control by continuously adapting to time-varying dynamics. Typically, these algorithms consider a model structure that lacks parsimony and offers…

Systems and Control · Electrical Eng. & Systems 2025-04-28 Koen Classens , Rodrigo A. González , Tom Oomen
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