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Objectives: The main objective of this review article is to evaluate the usability of Computational Fluid Dynamics (CFD) as a supporting clinical tool for respiratory system. Data Source: The English articles referred for this review paper…

Fluid Dynamics · Physics 2023-10-24 Rajneesh Kashyap , R. Thundil Karuppa Raj

For the one billion sufferers of respiratory disease, managing their disease with inhalers crucially influences their quality of life. Generic treatment plans could be improved with the aid of computational models that account for…

While the identification of nonlinear dynamical systems is a fundamental building block of model-based reinforcement learning and feedback control, its sample complexity is only understood for systems that either have discrete states and…

Machine Learning · Statistics 2020-06-19 Horia Mania , Michael I. Jordan , Benjamin Recht

In the present paper, two existing nonlinear system identification methodologies are used to identify data-driven models. The first methodology focuses on identifying the system using steady-state excitations. To accomplish this, a…

Systems and Control · Electrical Eng. & Systems 2020-11-18 Maren Scheel , Gleb Kleyman , Ali Tatar , Matthew R. W. Brake , Simon Peter , Jean-Philippe Noël , Matthew S. Allen , Malte Krack

We present a Bayesian dynamical inference method for characterizing cardiorespiratory (CR) dynamics in humans by inverse modelling from blood pressure time-series data. This new method is applicable to a broad range of stochastic dynamical…

Data Analysis, Statistics and Probability · Physics 2009-11-11 D. G. Luchinsky , V. N. Smelyanskiy , M. M. Millonas , A. Stefanovska , P. V. E. McClintock

This paper presents a data-driven algorithm for simultaneous system identification and parameter estimation in control-affine nonlinear systems. Parameter estimation is achieved by training a data-driven predictive model using state-action…

Optimization and Control · Mathematics 2026-04-28 Moad Abudia , Opeyemi Owolabi , Joel A. Rosenfeld , Rushikesh Kamalapurkar

Monitoring the respiratory rate is crucial for helping us identify respiratory disorders. Devices for conventional respiratory monitoring are inconvenient and scarcely available. Recent research has demonstrated the ability of non-contact…

Robotics · Computer Science 2022-07-27 Haimiao Mo , Shuai Ding , Shanlin Yang , Athanasios V. Vasilakos , Xi Zheng

We propose an algorithm to actively estimate the parameters of a linear dynamical system. Given complete control over the system's input, our algorithm adaptively chooses the inputs to accelerate estimation. We show a finite time bound…

Machine Learning · Computer Science 2020-06-23 Andrew Wagenmaker , Kevin Jamieson

We develop a technique for the multivariate data analysis of perturbed self-sustained oscillators. The approach is based on the reconstruction of the phase dynamics model from observations and on a subsequent exploration of this model. For…

Medical Physics · Physics 2019-06-03 M. Rosenblum , M. Frühwirth , M. Moser , A. Pikovsky

Online parameter identification is of importance, e.g., for model predictive control. Since the parameters have to be identified simultaneously to the process of the modeled system, dynamical update laws are used for state and parameter…

Numerical Analysis · Mathematics 2016-04-20 Romana Boiger , Barbara Kaltenbacher

Pulmonary hypertension (PH), defined by a mean pulmonary arterial pressure (mPAP) $>$ 20 mmHg, is characterized by increased pulmonary vascular resistance and decreased pulmonary arterial compliance. There are few measurable biomarkers of…

Quantitative Methods · Quantitative Biology 2025-06-06 Amanda L. Colunga , Mitchel J. Colebank , REU Program , Mette S. Olufsen

This paper presents a method for investigating, through an automatic procedure, the (lack of) identifiability of parametrized dynamical models. This method takes into account constraints on parameters and returns parameters whose…

Dynamical Systems · Mathematics 2016-10-11 Nathalie Verdière , Sébastien Orange

We present a novel computational model for the dynamics of alveolar recruitment/derecruitment (RD), which reproduces the underlying characteristics typically observed in injured lungs. The basic idea is a pressure- and time-dependent…

The arterial system dynamically loads the heart through changes in arterial compliance. The pressure-volume relation of arteries is known to be nonlinear, but arterial compliance is often modeled as a constant value, due to ease of…

Quantitative Methods · Quantitative Biology 2014-03-26 Timothy S. Phan , John K-J. Li

We study parameter estimation for the two state model which describes the balance equation for carbon dioxide and oxygen in human respiratory system. These are nonlinear parameter dependent and because of the transport delay in the…

Dynamical Systems · Mathematics 2022-07-18 Nirjal Sapkota , Janos Turi

We propose a technique for the design and analysis of adaptation algorithms in dynamical systems. The technique applies both to systems with conventional Lyapunov-stable target dynamics and to ones of which the desired dynamics around the…

Optimization and Control · Mathematics 2007-05-23 Tyukin Ivan , Danil Prokhorov , Cees van Leeuwen

Nonlinear systems are capable of displaying complex behavior even if this is the result of a small number of interacting time scales. A widely studied case is when complex dynamics emerges out of a nonlinear system being forced by a simple…

Quantitative Methods · Quantitative Biology 2015-06-01 Leandro M. Alonso

Increasingly demanding performance requirements for dynamical systems motivates the adoption of nonlinear and adaptive control techniques. One challenge is the nonlinearity of the resulting closed-loop system complicates verification that…

Systems and Control · Computer Science 2017-10-03 John F. Quindlen , Ufuk Topcu , Girish Chowdhary , Jonathan P. How

Respiratory ailments are increasing globally at an alarming rate and are currently one of the leading factors of death and infirmity worldwide. Among respiratory diseases, those linked to poor air quality and pollutants are increasing at a…

Quantitative Methods · Quantitative Biology 2025-12-03 Shelby Lacouture , Mitchell Kelley , Noah Plues , Laszlo Hunyadi , Emily Sundman , Annette Sobel , Robert V. Duncan

In this work we present, for the first time, a computational fluid dynamics tool for the simulation of the metered discharge in a pressurized metered dose inhaler. The model, based on open-source software, adopts the Volume-Of-Fluid method…

Fluid Dynamics · Physics 2025-08-08 Riccardo Rossi , Ciro Cottini , Andrea Benassi